2015
DOI: 10.1590/s1677-5538.ibju.2014.0411
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A Novel Approach for the Treatment of Radiation-Induced Hemorrhagic Cystitis with the GreenLight<sup>™</sup> XPS Laser

Abstract: Introduction:The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. It is a progressive disease that can lead to the need for blood transfusion, hospitalizations, and surgical interventions. This tends to affect the quality of life of these patients, and management can at times be difficult. We have evaluated the GreenLight Xcelerated Performance System (XPS) with TruCoag, although primarily used for management of benign prostatic … Show more

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Cited by 19 publications
(8 citation statements)
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“…Two small case series of patients with radiation-induced haemorrhagic cystitis report clearance of haematuria after one treatment with the GreenLight Xcelerated Performance System (XPS) or GreenLight potassium-titanyl-phosphate (KTP) laser [ 52 , 53 ]. A second case series of twenty patients undergoing endoscopic treatment with the GreenLight KTP laser reported a 92.3% rate of resolution of haematuria, although 25% of patients required multiple treatments.…”
Section: Treatmentmentioning
confidence: 99%
“…Two small case series of patients with radiation-induced haemorrhagic cystitis report clearance of haematuria after one treatment with the GreenLight Xcelerated Performance System (XPS) or GreenLight potassium-titanyl-phosphate (KTP) laser [ 52 , 53 ]. A second case series of twenty patients undergoing endoscopic treatment with the GreenLight KTP laser reported a 92.3% rate of resolution of haematuria, although 25% of patients required multiple treatments.…”
Section: Treatmentmentioning
confidence: 99%
“…More than a decade ago, a Cochrane Database systematic literature review on non-surgical interventions for late radiation cystitis in patients who underwent radical radiotherapy to the pelvis concluded that in the absence of randomized controlled studies it is impossible to set definitive rules for treatment ( 5 ). Recently, there have been reports of KTP laser use in an attempt of haemostasis with minimal mucosal destruction with promising results as a final step before definitive treatment ( 18 , 19 ). In case of intractable haemorrhage, arterial embolization or ligation and/or cystectomy represent definitive treatment, at the cost of increased morbidity.…”
Section: Discussionmentioning
confidence: 99%
“…If acute active bleeding does persist and is refractory to irrigations, electrocoagulation should be discussed, as described by Martinez and colleagues [ 18 ]. The procedure was performed with a rigid 22 French cystoscope.…”
Section: Current Treatments and Clinical Trialsmentioning
confidence: 99%
“…Very minimal bladder mucosal damage was reported. Then, a large three-way catheter was placed, and continuous irrigation was maintained overnight and stopped the next morning [ 18 ].…”
Section: Current Treatments and Clinical Trialsmentioning
confidence: 99%