Reliability and Validity of a Chinese Version of Urinary Tract Infection Symptom Assessment Questionnaire

Abstract

Objectives:Our study evaluates the reliability and validity of a Chinese version of the Urinary Tract Infection Symptom Assessment questionnaire (UTISA).Material and Methods:Our study enrolled women who were diagnosed with uncomplicated urinary tract infection (uUTI) at clinics. The Chinese version of UTISA was completed upon first visit to the clinic for uUTI and at 1-week follow-up. We enrolled 124 age-matched women without uUTI from the community as the control group. The UTISA consists of 14 items (seven symptom items and seven related to quality of life), with each item scoring 0 to 3. The internal consistency was assessed with Chronbach's alpha test. Factor analysis was used to classify symptoms into latent factors. The predictive validity was analyzed by using logistic regression and Receiver Operating Characteristic (ROC) curve analysis.Results:Mean total symptom scores of the UTISA in the 169 cases and 124 controls were 8.9±4.6 and 1.4±2.4, respectively (p<0.01). The alpha coefficient was 0.77, showing a homogeneous composition of symptoms. At a cut-off value of greater than 3, the UTISA symptom score had good predictive value for uUTI (sensitivity of 87.0%, and specificity of 93.1%). Factor analysis revealed two latent variables: 1) lower urinary tract symptoms and 2) physical symptoms. Among the seven items, we found that urinary frequency (OR=2.6), dysuria (OR=5.0), sense of incomplete emptying (OR=2.0), and hematuria (OR=7.6) were significant predictors for uUTI.Conclusions:The Chinese version of UTISA is reliable to predict uncomplicated UTI in women with an optimal cut-off point at >3.

Reliability of Symptom-Based Diagnosis of Uncomplicated Cystitis

“…Either the original English or the translated versions in different languages (Uzbek, Russian, Italian, Chinese) of the UTISA were used as primary or additional symptom-assessment tools in studies [47][48][49][50][51]. Although the authors of the original UTISA did not aim to establish a cutoff value to differentiate between AC and other conditions, Chang et al [51] revealed such a cutoff value using the total summary score in a translated and validated Chinese version of the UTISA, using receiver operating characteristic-curve analysis.…”

Rapid differentiation of cocci/mixed bacteria from rods in voided urine culture of women with uncomplicated urinary tract infections

“…There are several limitations in our study. The major limitation is that the study is a retrospective review, which is biased in its nature and we did not use a validated symptom score to evaluate the symptoms of the enrolled subjects. Although we excluded urine specimens that were not performed within 4 hours of the collection of the specimen, recent antibiotics use and also the factors that may have compromised the results.…”

A study to evaluate the efficacy of cranberry extract supplements in prevention of recurrent urinary tract infections in female patients

“…Approximately 80% of all UTIs occur in women and 20% to 30% of women with a UTI will experience recurrence. 16 Nowadays the incidence of recurrence is increasing and usually low dose antibiotic prophylaxis for several months are recommended. But antibiotic use is associated with the development of antibiotic resistance and the occurrence of side effects.…”