Efficacy and safety of propiverine and terazosine combination for one year in male patients with luts and detrusor overactivity

Abstract

Purpose: To evaluate the long term efficacy and safety of the use of propiverine and terazosine combination in patients with LUTS and DO by a placebo controlled study. Materials and Methods: One hundred patients were enrolled in the study. They were randomized into two groups (each group consisted of 50 patients). Terazosine and placebo were administered to the patients in Group 1 and terazosine plus propiverine HCL was administered to Group 2. The patients were evaluated by international prostate symptom score (IPSS), the first four questions of IPSS (IPSS4), the 8th question of IPSS (quality of life-QoL), overactive bladder symptom score questionnaire (OAB-q V8), PSA test, urodynamic studies, post voiding residue (PVR). All patients were followed for one year and were reassessed for comparison. Results: IPSS, IPSS4, OAB symptoms, QoL score, PVR, and Qmax scores of the groups did not differ. After one year treatment, there was significant improvement in IPSS, IPSS4, OAB symptoms, QoL and Qmax values in Group 2. No significant improvement was noted for the same parameters in Group 1. Conclusion: This is the first study to show long term safety and efficacy of anticholinergic therapy for patients with LUTS. In patients with OAB or DO, long term anticholinergic treatment may be regarded as a treatment option.

Role of Antimuscarinics Combined With Alpha-blockers in the Management of Urinary Storage Symptoms in Patients With Benign Prostatic Hyperplasia: An Updated Systematic Review and Meta-analysis

“…The risk of publication bias estimation through funnel plots and Eger's test showed significant asymmetry. The asymmetry was particularly observed for frequency (p<0.01) with studies seeming to be missing in areas of non-significance, which could be due to reporting studies 17,18,22 required ≥3 urgency episodes per 24 h at baseline. Second, differences between alpha-blocker treatments may also be accountable for the differences in efficacy between studies.…”

“…A meta-analysis of urgency and frequency showed substantial between-study heterogeneity. The examination of individual trials and subgroup characteristics identified Lee et al 2011 22 as an outlier for both outcomes, mainly because of its wide confidence interval.…”

“…Overall, seven RCTs including 2003 patients evaluated the impact of antimuscarinics on PVR. 9,10,16,19,[21][22][23] The meta-analysis showed a statistically significant increase in PVR with the use of antimuscarinics (SMD=0.26 [95%CI: 0.13; 0.39]; p<0.01, I 2 =26%; Figure 5A). However, the raw mean increase in PVR ranged from 1-25.5 mL which was not considered clinically significant.…”

Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis

“…In all, 10 articles with 9 RCTs were included in the analysis, with 5 RCTs [6,[8][9][10][11] for propiverine hydrochloride for overactive bladder (Figs. 2, 3, and 4) and 4 RCTs [12][13][14][15] for propiverine hydrochloride for overactive bladder and in adult with lower urinary tract symptoms (Fig. 5).…”

Primary Care Evaluation and Treatment of Men With Lower Urinary Tract Symptoms

“…8 Detrusor overactivity is a urodynamic observation characterized by spontaneous or provoked involuntary detrusor contractions during the filling phase. 9 Other causes of LUTS include genitourinary cancer, urethral strictures, prostatitis, comorbid conditions, medications, and pelvic trauma or surgery. 10,11 For these reasons, management of LUTS requires a physician who is knowledgeable about the lower urinary tract.…”