Surgical Management of a Locally Advanced Symptomatic Recurrence of Penile Sarcoma Secondary to Prostate Brachytherapy

Introduction: Primary penile sarcoma has an incidence of 0.6 in 100,000 patients in developed countries. Risk factors such as radiotherapy have been identified, which can generate mutagenesis of the irradiated tissue adjacent to the irradiation field. Given the increase in survival of patients that received radiotherapy, the incidence of radio-induced sarcomas has increased. We report the first documented case in Latin America of radio-induced undifferentiated sarcoma of the penis. Materials and Methods:Case report and literature review. Results:We report the case of an 89 year-old male patient, who consulted due to a 9-month history of intermittent urethrorrhagia, penile pain and priapism. It is noteworthy that he received radiotherapy for prostate adenocarcinoma. Ultrasound and MRI of the pelvis confirmed a tumor dependent on the right corpus cavernosum, and it was decided to take a biopsy of the mass. Biopsy of the lesion showed a high-grade undifferentiated sarcoma. He underwent radiotherapy and surgery, he had an unfavorable evolution and died shortly after. Conclusion:Radio induced sarcomas of the penis are rare and usually have a poor prognosis due to delayed diagnosis. Its early diagnosis is difficult because the initial symptomatology is nonspecific, very similar, for example, to that of Peyronie's disease. Thus, a suspicion and timely identification can impact the prognosis of these neoplasms.

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“…He was taken for surgical resection. The report does not specify the type of sarcoma nor the time or duration of radiotherapy [21].…”

Section: Sarcoma Of the Penis Clinical Behavior And Histological Vari...mentioning

confidence: 99%

Primary Radiation-Induced Sarcoma of the Penis: Case Report and Review of the Literature

Arenas¹,

Guillermo²,

Julian³

et al. 2022

Int Arch Urol Complic

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Incidence of Second Malignancies in Prostate Cancer Patients Treated With Low-Dose-Rate Brachytherapy and Radical Prostatectomy

Hamilton

Tyldesley

Hamm

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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Surgical Management of a Locally Advanced Symptomatic Recurrence of Penile Sarcoma Secondary to Prostate Brachytherapy

Cited by 2 publications

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Primary Radiation-Induced Sarcoma of the Penis: Case Report and Review of the Literature

Primary Radiation-Induced Sarcoma of the Penis: Case Report and Review of the Literature

Incidence of Second Malignancies in Prostate Cancer Patients Treated With Low-Dose-Rate Brachytherapy and Radical Prostatectomy

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