Basic Research in Prostate Cancer, Kidney Cancer, Urinary Incontinence, Pediatric Urology and Erectile Dysfunction

Favorito, Luciano A.

doi:10.1590/s1677-5538.ibju.2013.02.01

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human renal cancer is a genetic disease caused by a series of genetic alterations (Favorito, 2013;Oosterwijk et al, 2011). Increasing respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Human renal cancer is a genetic disease caused by a series of genetic alterations (Favorito, ; Oosterwijk et al, ). Increasing evidence has proved the indispensable roles of lncRNAs in cancer development and progression, and epigenetic dysregulation has been found to involve almost all cellular processes of cancer, the present study aimed to explore putative lncRNAs epigenetically regulated during human RCC carcinogenesis and progression.…”

Section: Discussionmentioning

confidence: 99%

“…These results indicated that MGP might be a downstream molecule of HNF4A and NR_023387. As Human renal cancer is a genetic disease caused by a series of genetic alterations (Favorito, 2013;Oosterwijk et al, 2011). Increasing NR_023387 is a lncRNA with 736nt in length, its encoding genes located on the antisense strand of chromosome 16.…”

Section: Tumor-suppressive Functions Of Nr_023387 In Rccmentioning

confidence: 99%

See 2 more Smart Citations

RETRACTED: Silencing of tumor‐suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency

Zhou

Guo

Yao

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Dysregulation of the epigenetic status of long noncoding RNAs (lncRNAs) has been linked to diverse human diseases including human cancers. However, the landscape of the whole-genome methylation profile of lncRNAs and the precise roles of these lncRNAs remain elusive in renal cell carcinoma (RCC). We first examined lncRNA expression profiles in RCC tissues and corresponding adjacent normal tissues (NTs) to identify the lncRNA signature of RCC, then lncRNA Promoter Microarray was performed to depict the whole-genome methylation profile of lncRNAs in RCC. Combined analysis of the lncRNAs expression profiles and lncRNAs PromoterMicroarray identified a series of downregulated lncRNAs with hypermethylated promoter regions, including NR_023387. Quantitative real-time polymerase chain reaction (RT-PCR) implied that NR_023387 was significantly downregulated in RCC tissues and cell lines, and lower expression of NR_023387 was correlated with shorter overall survival. Methylation-specific PCR, MassARRAY, and demethylation drug treatment indicated that hypermethylation in the NR_023387 promoter contributed to its silencing in RCC. Besides, HNF4A regulated the expression of NR_023387 via transcriptional activation. Functional experiments demonstrated NR_023387 exerted tumor-suppressive roles in RCC via suppressing the proliferation, migration, invasion, tumor growth, and metastasis of RCC. Furthermore, we identified MGP as a putative downstream molecule of NR_023387, which promoted the epithelial-mesenchymal transition of RCC cells. Our study provides the first whole-genome lncRNA methylation profile in RCC. Our combined analysis identifies a tumor-suppressive and prognosis-related lncRNA NR_023387, which is silenced in RCC via promoter hypermethylation and HNF4A deficiency, and may exert its tumorsuppressive roles by downregulating the oncogenic MGP. K E Y W O R D SHNF4A, long noncoding RNA, matrix Gla protein, methylation, NR_023387, renal cell carcinoma

show abstract

“…Human renal cancer is a genetic disease caused by a series of genetic alterations (Favorito, 2013;Oosterwijk et al, 2011). Increasing respectively.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tumor-suppressive Functions Of Nr_023387 In Rccmentioning

confidence: 99%

See 1 more Smart Citation