Endotelium in Turner syndrome with capillaroscopy

Abstract

Objective: The aim of this study was to assess the endothelium function in patients with Turner syndrome using videocapillaroscopy and to compare the results with healthy control. Methods: Subjects and controls were studied in a temperature-controlled room, 20 days after no nailfold manipulations. The capillaries were visualized by a microscope connected to a television and a computer. The test of post-occlusive reactive hyperemia was performed using a sphygmomanometer attached to the fourth left finger, 20mmHg above maximum arterial pressure during 1 minute, and the following patterns were studied: area of transverse segment, maximal post-ischemia area and time to reach maximal post-ischemia area. Results: The value of measure of transverse segment projected area , the maximal postischemia area of hand nailfold capillary loops using computerized videophotometry and the time to reach maximal post ischemia area were studied in 40 patients with Turner syndrome and 26 healthy women controls of comparable age (20±7.5 versus 18±8.1 years old; p=0.57). There were differences between transverse segment area (706.8±139.1 versus 548.8±117.2; p=0.001). Maximal post-ischemia area (891.3±226.1 versus 643.5±134.3; p=0.001) and the time to reach it (10.8±4.3 versus 5.5±2.5; p=0.001) were different between patients and controls. Conclusions: Changes of capillary response to ischemia could be observed in patients with Turner syndrome using videocapillaroscopy when they were compared to a healthy control group.Keywords: Turner syndrome; microscopic angioscopy; endothelium. ResumoObjetivos: O objetivo deste estudo foi avaliar a função endotelial de pacientes com síndrome de Turner, utilizando a videocapilaroscopia e comparar os resultados com grupo controle saudável. Métodos: Pacientes e controles foram estudados em sala com temperatura controlada, após 20 dias, sem a manipulação das cutículas. Os capilares foram visualizados por microscópio conectado a televisão e computador. O teste de hiperemia reativa pós-oclusiva foi realizado utilizando-se esfigmomanômetro fixado no quarto quirodáctilo da mão esquerda, 20mmHg acima da pressão arterial máxima durante 1 minuto, e os seguintes parâmetros foram estudados: área do segmento transverso, área máxima pós-hiperemia e tempo para alcançar a área máxima pós-hiperemia. Resultados: O valor da área do segmento transverso, área máxima pós-hiperemia dos capilares da região da mão usando-se a videocapilaroscopia computadorizada e o tempo para alcançar a área pós-hiperemia foram estudadas em 40 pacientes com síndrome de Turner e 26 controles do sexo feminino pareados para idade (20±7,5 versus 18±8,1 anos; p=0,57). Houve diferenças nos grupos quanto à área do segmento transverso (706,8±139,1 versus 548,8±117,2; p=0,001). A área máxima pós-hiperemia (891,3±226,1 versus 643,5±134,3; p=0,001) e o tempo para alcançá-la (10,8±4,3 versus 5,5±2,5; p=0,001) foram significativamente diferentes entre pacientes e controles. Conclusão: Houve alterações na resposta do capilar à isquemia em pacientes...

Potential Effects of Whole-Body Vibration Exercises on Blood Flow Kinetics of Different Populations: A Systematic Review With a Suitable Approach

“…Johnson et al (2014) with a single session, also observed a significant increase in the skin blood flow. These findings are of clinical importance due to endothelial dysfunction with capillary alterations and impairment of the blood flow in this population group (Rajendran et al, 2013;Coelho et al, 2011;Widmer and Lerman 2014;Murray et al, 2004). After 12-week WBV training changes on leg blood flow were accompanied by positive changes in body composition (Sañudo et al, 2013).…”

“…As a consequence, older adults would be less able to adequately thermoregulate and repair cutaneous wounds (Tew et al, 2012). In several clinical disorders, as in diabetes and in rheumatologic diseases, endothelial dysfunction occurs with an impairment of the microcirculation (Rajendram et al, 2013;Coelho et al, 2011;Widmer and Lerman 2014;Murray et al, 2004) and inhibition of blood flow restoration (Hadi et al, 2005), which may be also related to arterial stiffness (Zanoli et al, 2015). Moreover, Simmonds et al (20130, have reported that impaired blood fluidity in humans of advanced age, includes enhanced plasma and whole blood viscosity, impaired red blood cell (RBC) deformability and enhanced RBC aggregation.…”