A influência dos ácidos graxos trans na disfunção da célula endotelial e o possível efeito terapêutico do exercício sobre o tecido endotelial como forma de prevenção ou regressão da aterosclerose

Masi, Laureane Nunes; Silva, Érica Paula Portioli

doi:10.1590/s1677-54492009000200012

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…Studies on the influence of exercise on the human body (Almeida, 2007;Lizardo et al, 2007), and also in animals (Camargo Filho et al, 2005;Araújo et al, 2009;Masi & Silva, 2009) are diverse and well disseminated, but regarding experiments on fluid restriction, reports are scarce, specifically in relation to animal experiments (Prazeres et al;Tomanari et al, 2003Tomanari et al, , 2007.…”

Section: Discussionmentioning

confidence: 99%

Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction

Lorençoni

Pelai

Godoy³

et al. 2015

Int. J. Morphol.

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SUMMARY:Physical effort stimulates an increase in oxygen consumption in tissues, generating toxic chemical species derived from oxygen (ROS), which are considered the initiators of the lipid peroxidation process (LPO), the major mechanism of cellular injury. As the essential mechanism for maintaining the electrolyte balance depends on an effective kidney function, oxidative stress in this organ can be a key factor in the development and persistence of hypertension. This study aimed to determine the kidney changes induced by a combination of fluid restriction and exercise in rats. The study consisted of 24 male Wistar rats of 90 days of age, divided into four groups, two of which were submitted to water restriction and exercise on a treadmill. Twenty-four hours after the last training session, the animals were euthanized and the left kidney was removed. The upper part of the kidney was used for the histological procedures and the lower part for the quantification of membrane lipoperoxides. Analysis of variance was applied after testing the normality of data, and the comparison between groups was performed using the Bonferroni test, adopting a significance of p<0.05. The restriction had an influence on body weight; kidney weight; proximal tubule maximum diameter; and area, perimeter and diameter of glomeruli, whereas the exercise affected the weight and the minimum diameter of the proximal tubule. According to the TBARS (thiobarbituric acid reactive substances) method, there was a difference between the G1 (control) and G3 (sedentary with water restriction) and between the G2 (exercised with water) and G4 (exercised with water restriction) compared to G1. The treadmill exercise combined with the water restriction promoted structural changes in the glomeruli and promoted oxidative stress, although neither variable corroborated for the potentiating of lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction

Lorençoni

Pelai

Godoy³

et al. 2015

Int. J. Morphol.

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“…É importante ressaltar que o mecanismo básico dos efeitos da gordura trans no processo inflamatório ainda não está completamente estabelecido. Contudo, as pesquisas amplamente publicadas, mostrando as consequências finais de um alto consumo desses lipídeos, são tidas no campo científico como suficientes para estabelecerem a contraindicação de seu consumo na dieta do dia-a-dia (MASI;SILVA, 2009).…”

Section: Gordura Trans E Inflamação Sistêmicaunclassified

“…O tecido adiposo possui uma capacidade de estocar quantidades mais significativas dos ácidos graxos em forma de triglicerídeos, enquanto em outros tecidos a limitação é maior. Assim, ocorre a chamada lipotoxicidade quando há excesso de acúmulo dos lipídeos, podendo levar à disfunção celular (MASI;SILVA, 2009).…”

Section: Gordura Trans E Doenças Cardiovascularesunclassified

“…Isso altera a resposta inflamatória das células, ativando acentuadamente esse sistema, aumentando os níveis de Interleucina-6 e MCP-1, como já foi constatado nesse trabalho. É relevante destacar que ainda não é completamente esclarecido o mecanismo do aumento dessas substâncias inflamatórias pelos ácidos graxos trans (MASI;SILVA, 2009).…”

Section: Gordura Trans E Doenças Cardiovascularesunclassified

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Gordura Trans: Mecanismos Bioquímicos E Patologias Associadas

et al. 2020

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Nowadays, eating habits have been shown to be extremely harmful to human metabolism with the increasingly relevant intake of trans fats, especially by young people. These fats are present in large concentrations in numerous food products such as margarine, ice cream, cookies, and fried foods. The damage from high intake can be seen in the increase in cardiovascular disease. In this manner, the goal of this work is to conceptualize trans fat and to outline its negative effects on the body. The work becomes relevant because it can contribute to the construction of assertive guidelines to conduct the change in dietary habits, eliminating trans fat from the diet as recommended by the World Health Organization (WHO). The research is a descriptive study, made from surveys in specialized literature. At the beginning of the 20th century, through industrialization, a process to convert liquid oils into solid and semi-solid oils was discovered to extend their validity. Thus, through partial hydrogenation, trans fat was formed, which consists of an unsaturated fatty acid, with at least one double bond in the trans position. Thus, with the increase in consumption, the deleterious effects of this intake vary, such as cardiovascular diseases, increased percentage of adipose tissue in the body, obesity. Some studies also show its association with diabetes mellitus, depression, infertility, and tumor growth.

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A influência dos ácidos graxos trans na disfunção da célula endotelial e o possível efeito terapêutico do exercício sobre o tecido endotelial como forma de prevenção ou regressão da aterosclerose

Cited by 2 publications

References 42 publications

Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction

Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction

Gordura Trans: Mecanismos Bioquímicos E Patologias Associadas

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