Psicose e depressão na epilepsia do lobo temporal

Kandratavicius, Ludmyla; Hallak, Jaime Eduardo Cecílio; Leite, João Pereira

doi:10.1590/s1676-26492007000400004

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…It is evidenced by the literature that the non-control of epileptic seizures directly impacts the patient’s quality of life; thus, the higher the frequency/intensity of the seizures, the more prevalent are the desadaptive emotional symptoms. The prevalence of depression varies from 20 to 55% in patients with recurrent seizures and from 3 to 9% in patients with controlled seizures [30, 31].…”

Section: Discussionmentioning

confidence: 99%

Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

et al. 2021

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Temporal lobe epilepsy (TLE) is considered to be the most common form of epilepsy, and it has been seen that most patients are refractory to antiepileptic drugs. A strong association of this ailment has been established with psychiatric comorbidities, primarily mood and anxiety disorders. The side of epileptogenic may contribute to depressive and anxiety symptoms; thus, in this study, we performed a systematic review to evaluate the prevalence of depression in TLE in surgical patients. The literature search was performed using PubMed/Medline, Web of Science, and PsycNet to gather data from inception until January 2019. The search strategy was related to TLE, depressive disorder, and anxiety. After reading full texts, 14 articles meeting the inclusion criteria were screened. The main method utilized for psychiatric diagnosis was Diagnostic and Statistical Manual of Mental Disorders/Structured Clinical Interview for DSM. However, most studies failed to perform the neuropsychological evaluation. For those with lateralization of epilepsy, focus mostly occurred in the left hemisphere. For individual depressive diagnosis, 9 studies were evaluated, and 5 for anxiety. Therefore, from the data analyzed in both situations, no diagnosis was representative in preoperative and postoperative cases. In order to estimate the efficacy of surgery in the psychiatry episodes and its relation to seizure control, the risk of depression and anxiety symptoms in epileptic patients need to be determined before surgical procedures. Rigorous preoperative and postoperative evaluation is essential for psychiatry conditions in patients with refractory epilepsy candidates for surgery.

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Section: Discussionmentioning

confidence: 99%

Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

et al. 2021

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“…Sendo assim, comorbidades psiquiátricas em pacientes portadores de ELTM podem se tornar mais frequentes, em resposta a uma condição crônica das crises epilépticas. Estima-se que destes pacientes cerca de 30 a 70% apresentam alterações de ordem cognitiva e/ou psíquica que surgem após anos do início das crises (Kandratavicius et al, 2007). Esse intervalo pode ser justificado em decorrência de um foco irritativo no cérebro, dano cerebral ou cronicidade da doença (De Oliveira & Gouveia, 2003;De Castro et al, 2008).…”

Section: Epilepsia E Psicosesunclassified

Modelo animal de epilepsia e psicose comórbida: aspectos neuropatológicos, corportamentais e modulação pelo tratamento com nitroprussiato de sódio

Balista¹

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A minha mãe Edna que me viu primeiro, a minha inspiração, que optou ser feliz por me ver brilhar. Hoje voo sozinha, mas minhas asas são você. Minha eterna gratidão ao meu primeiro amor na vida e para sempre o mais importante. Ao meu irmão Ridan pela amizade, confiança, à quem não temo declarar o meu amor. Somos dois e também apenas um, não vivo sem que esteja sempre ao meu lado a melhor parte de mim! VI AGRADECIMENTOS A DEUS pelo direcionamento, conquistas e me fazer chegar até o fim. Fé torna as coisas possíveis e ciência e DEUS se atraem. Ao Prof. Jaime Eduardo Cecílio Hallak sou profundamente grata por sua orientação, atenção, disposição, por caminhar junto e enorme incentivo, exemplo de seriedade e competência científica. À Dra. Ludmyla Kandratavicius sou profundamente grata pela espetacular coorientação, pela competência científica, pelo crescimento acadêmico, suporte, apoio, presença constante do começo ao fim, pela amizade inestimável e para sempre. Ao Prof. João Pereira Leite pelo apoio, suporte e todo conhecimento científico adquirido desde o mestrado. Ao Dr. José Eduardo Peixoto-Santos pelo apoio, incentivo, presença, suporte durante o trabalho, pela amizade valiosa e para sempre À Renata Caldo Scandiuzzi pelos ensinamentos, eficiência, apoio, incentivo, presença, suporte durante todo o trabalho, pela amizade valiosa e para sempre Às Dras. Mariana Raquel Monteiro e Raquel Do-Val da Silva pelo apoio e suporte durante o trabalho e pela grande amizade. Aos Drs. Glen Baker e Serdar Dursun sou profundamente grata por me acolherem na Universidade de Alberta (Canadá) e me proporcionarem conhecimento e crescimento científico. Obrigada pelo acompanhamento no doutorado sanduiche. A Silvana Loturco e Renato Meirelles funcionários do departamento de Neurociências e Ciências do Comportamento sempre disponíveis e atenciosos. À agência de fomentos CAPES pelo apoio financeiro direito e também apoio no doutorado sanduiche para o desenvolvimento desse trabalho. VIII com epilepsia. Além disso, não exacerbou crises e contribuiu para diminuição delas nos animais do modelo de epilepsia e psicose, que apresentou grandes similaridades com o que é encontrado em casos clínicos. Nossos resultados sugerem que o uso do NPS pode ter resultados na melhoria dos sintomas da psicose interictal humana, assim como já observado para a esquizofrenia. Palavras-chave: psicose, epilepsia, comorbidade psiquiátrica, modelo animal, quetamina, pilocarpina, nitroprussiato de sódio.

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“…Outros estudos observaram melhora significativa em testes de função executiva, atenção e velocidade psicomotora em pessoas com epilepsia do lobo temporal esquerda ou direita (Shin et al, 2009 (Kandratavicius et al;.…”

Section: Atenção E Funções Executivasunclassified

Memória prospectiva após ressecção mesial temporal

Adda¹

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Introduction: Prospective memory (PM) refers to a set of cognitive abilities that allow recall of a previous intention to perform in the future, in the appropriate setting. This function is not usually evaluated in neuropsychological batteries used to evaluate people with epilepsy. Objective: We evaluated the impact of epilepsy surgery on the prospective component of PM, in people undergoing unilateral temporal lobectomy to treat medically refractory epilepsy. Methods: We compared performance in PM in people with left or right mesial temporal sclerosis (MTS) in the pre and postoperative periods with that of two control groups. One group was composed of people without epilepsy (normal controls), and another group was composed of people with epilepsy associated with mesial temporal sclerosis that underwent neuropsychological testing and retesting without undergoing surgery (clinical test/retest control group). Results: We studied 42 people without epilepsy, 20 clinical controls (test/retest group), and 39 patients that underwent epilepsy surgery (pre and postoperative testing). We compared groups performances and changes in individual performances with the reliable change index. Groups did not differ in age, education, and intelligence quotient. We found decreased preoperative PM performance for the clinical and surgical groups (p<0.01) (lesion effect), without a difference between right and left groups (laterality effect). Postoperatively, there was a significant (p<0.01) decrease in number of seizures, a small, but significant reduction in antiepileptic drug load, stable prospective memory, verbal and visual memory for right mesial temporal sclerosis, and decreased verbal memory in the left mesial temporal sclerosis group. Conclusion: In spite of a shared evocation system for episodic and prospective memory, resection of pathologically involved mesial temporal structures does not impact on prospective memory performance, even in the setting verbal memory decline in the left MTS group.The finding of dissociated verbal memory decline and PM stability after epilepsy surgery suggests a different role of mesial temporal lobe structures in these memory systems. The role of extratemporal and nonmesial temporal lobe structures in prospective memory in MTS patients should be evaluated in future studies.

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Psicose e depressão na epilepsia do lobo temporal

Cited by 5 publications

References 39 publications

Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

Modelo animal de epilepsia e psicose comórbida: aspectos neuropatológicos, corportamentais e modulação pelo tratamento com nitroprussiato de sódio

Memória prospectiva após ressecção mesial temporal

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