Drug-induced gingival enlargement - Part II. Antiepileptic drugs: not only phenytoin is involved

Lin, Kátia; Guilhoto, Laura Maria de Figueiredo Ferreira; Yacubian, Elza Márcia Targas

doi:10.1590/s1676-26492007000200009

Cited by 17 publications

(9 citation statements)

References 39 publications

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“…There are reports that the use of phenobarbital and valproic acid can induce gingival hyperplasia . Despite being an extremely rare condition three factors can be important in the manifestation of gingival hyperplasia: the use of a variation of the drug, plaque‐induced inflammatory changes, and genetic factors .…”

Section: Discussionmentioning

confidence: 99%

Dental findings in children with West syndrome

Neta

Souza

Alencar

et al. 2014

Special Care in Dentistry

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Section: Discussionmentioning

confidence: 99%

Dental findings in children with West syndrome

Neta

Souza

Alencar

et al. 2014

Special Care in Dentistry

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“…Gingival enlargement is the term used to describe medication-related gingival overgrowth or gingival hyperplasia, a common reactionary phenomenon that occurs due to the use of several types of therapeutic agents, including antiepileptic drugs. Valproic Acid has been linked to gingival overgrowth [10].…”

Section: Discussionmentioning

confidence: 99%

West Syndrome: Report of Clinical Case: 9 Years of Follow-up

Nacamura

Trize

Cabello

et al. 2018

RGO, Rev. Gaúch. Odontol.

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West Syndrome is one of the rare and severe childhood epilepsies, starting in the first year of life and having an uncertain etiology. Even if some of the symptoms are missing, a triad of them defines West Syndrome, including epileptic spasms, arrest or regression of psychomotor development, and hypsarrhythmia on interictal electroencephalography. The objective of this study was to obtain updated data on West Syndrome literature and report a clinical case of a patient with the medical diagnosis of this syndrome, with gastrostomy feed tube, and clinical pattern of spastic quadriplegia. Initial clinical examination showed prolonged retention of deciduous teeth, periodontal disease, poor oral hygiene, mouth breathing, deep palate, anterior open bite, tongue interposition between the dental arches, and low caries experience. Over 9 years the patient presented complications in their sistemicas conditions, with need for gastrostomy and many periods of hospitalization that determined periods of absence for the dental monitoring. Despite this, currently his oral health condition is good and stable. Dental care for people with disabilities should be developed, encouraged and continuously extended, in agreement with the constitutional principles of human dignity and the rights for health and equality.

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“…PGO seems to be more prevalent in children and teenagers, but there is no difference on its incidence in regard to gender or ethnic groups [14]. …”

Section: Clinical and Microscopic Features Of The Phenytoin-inducementioning

confidence: 99%

“…PGO can occur early within 3 months of the drug use and it may reach a state of equilibrium often within the first year of the beginning of medication [ 13 ]. PGO seems to be more prevalent in children and teenagers, but there is no difference on its incidence in regard to gender or ethnic groups [ 14 ].…”

Section: Clinical and Microscopic Features Of The Phenytoin-inducementioning

confidence: 99%

“…Growth is slow but in more severe cases it may go so far as to cover the whole tooth crown [ 13 ]. Few cases of PGO have also been reported in edentulous patients [ 18 ] and around deciduous teeth [ 14 ]. Likewise, there were some reports of GO in areas of dental implants in patients taking phenytoin [ 19 ].…”

Section: Clinical and Microscopic Features Of The Phenytoin-inducementioning

confidence: 99%

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Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

et al. 2011

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Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

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Drug-induced gingival enlargement - Part II. Antiepileptic drugs: not only phenytoin is involved

Cited by 17 publications

References 39 publications

Dental findings in children with West syndrome

Dental findings in children with West syndrome

West Syndrome: Report of Clinical Case: 9 Years of Follow-up

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

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