Hiperplasia gengival medicamentosa: parte I

Guimarães, J.M.

doi:10.1590/s1676-26492007000100008

Cited by 7 publications

(6 citation statements)

References 16 publications

(24 reference statements)

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“…This fact may have attenuated the strength of the association between income and the parameters measured in the present study. Generally, there was no correlation of DIGO with race, gender and age, as demonstrated by previous studies, although this fact is not consensual (2,14,24). In addition, the association between DIGO and pharmacological variables such as dose, concentration and time of treatment was not observed, in agreement with previous studies (11,16,24,25).…”

Section: Discussionmentioning

confidence: 53%

“…Phenytoin (5-diphenilphenytoin) has been used to control seizure crisis in patients since its clinical introduction by Merritt & Putnam in 1938 (5). DIGO is a frequent side effect in users of this drug (14). The population of this study was comprised of individuals with low schooling level and reduced family income, compatible with the profile of the population assisted by the Brazilian Primary Health Care System (15).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Fonseca

Júnior²,

Gonçalves

et al. 2010

Rev. odonto ciênc. (Online)

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Purposes: The aim of this study was to evaluate the prevalence of drug-induced gingival overgrowth (DIGO) in Brazilian users of nifedipine and/or phenytoin and to determine the presence of predisposing/modifying factors.Methods: Demographic, pharmacological, and periodontal data were obtained from 100 users of the Brazilian Primary Health Care System in Diamantina, Jequitinhonha Valley, Minas Gerais state, Brazil, who were taking nifedipine and/or phenytoin. Clinical evaluations including gingival overgrowth analysis were carried out by a single calibrated examiner. Bivariate analysis (Chi-square test or Student's t-test) were used to identify demographic, periodontal and drugrelated significant factors associated with gingival overgrowth severity. Multivariate analysis (Poisson regression) was used to assess confounding factors.Results: The prevalence of DIGO was high (86%), but its severity was predominately mild. The prevalence of DIGO was significantly higher in phenytoin users than in nifedipine users (P=0.01). There was no association between DIGO and demographic, pharmacological or periodontal variables.Conclusion: The high occurrence of DIGO among users of nifedipine and phenytoin emphasizes the importance of the dentist as part of the public health team to provide the prevention, early diagnostic, and control of this alteration.Key words: Nifedipine; phenytoin; gingival overgrowth; primary health care ResumoObjetivo: Avaliar a prevalência dos aumentos gengivais medicamentosos em usuários brasileiros de nifedipina e fenitoína e determinar a presença de fatores preditores/modificadores. Metodologia: Dados demográficos, farmacológicos e periodontais foram obtidos de 100 pacientes usuários da Atenção Primária no Vale do Jequitinhonha que usavam nifedipina e/ou fenitoína. Avaliações clínicas, incluindo a análise do aumento gengival, foram feitas por um avaliador calibrado. Análises bivariadas (teste do qui-quadrado ou teste t de Student) foram usadas para identificar fatores demográficos, periodontais e medicamentosos que apresentassem associação com a severidade do aumento gengival. Foi utilizada análise multivariada (regressão de Poisson) para estimar a razão de prevalência e intervalo de 95% de confiança para identificar os fatores de risco associados ao desenvolvimento do AG.Resultados: A prevalência do aumento gengival foi elevada (86%), mas a gravidade mais comumente observada foi a leve. A prevalência foi maior em usuários de fenitoína do que de nifedipina (P=0.01). Não houve associação entre aumento gengival e as variáveis demográficas, farmacológicas e periodontais.Conclusão: A alta prevalência do aumento gengival medicamentoso entre os usuários de nifedipina e fenitoína enfatiza a importância do cirurgião dentista no diagnóstico, prevenção e controle dessa alteração.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Fonseca

Júnior²,

Gonçalves

et al. 2010

Rev. odonto ciênc. (Online)

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“…There is some evidence of decreased collagen production after phenytoin administration in vitro [ 33 ]. Likewise, Kato et al [ 34 ] showed a reduction in mRNA expression of collagen type I and III associated with a higher density of these fibers in the PGO.…”

Section: Pathogenesis Of Pgomentioning

confidence: 99%

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

et al. 2011

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Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

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“…The precise mechanism by which drug-induced gingival enlargement occurs is still not completely understood, although a number of hypotheses have been suggested [6]. Phenytoin probably interacts with a subtype of susceptible fibroblasts, cyclosporine affects the metabolism of these cells and nifedipine enhances this effect reducing their metabolism [8,29]. Several factors may influence the relationship between the various implicated drugs and components of the gingival tissues, including: age, genetic predisposition, pharmacokinetic variables, drug-induced alterations in gingival connective tissue homeostasis, ultra structural factors and inflammatory changes, drug-induced action on growth factors, etc.…”

Section: Gender Distribution In the Study Samplementioning

confidence: 99%

Gingival Enlargement in Epileptic Patients on Phenytoin Therapy-An Evidence Based Approach

Nayyar¹

2012

J Neurol Neurophysiol

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Hiperplasia gengival medicamentosa: parte I

Cited by 7 publications

References 16 publications

Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

Gingival Enlargement in Epileptic Patients on Phenytoin Therapy-An Evidence Based Approach

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