Oxacillinase (OXA)-producing Acinetobacter baumannii in Brazil: clinical and environmental impact and therapeutic options

Medeiros, Micheli; Lincopán, Nilton

doi:10.1590/s1676-24442013000600003

Cited by 15 publications

(13 citation statements)

References 134 publications

(105 reference statements)

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“…A study in Romania reported highly resistant A. baumannii isolates with 75% resistance for ceftriaxone, ceftazidime, gentamicin and kanamycin antibiotics each [ 27 ] and a study conducted in Ethiopia also revealed 100% and 88% resistant Ciprofloxacin and Gentamicin A.baumannii from environmental isolates respectively [ 28 ]. Ciprofloxacin resistant, 86.5% A.baumannii isolates were also detected in clinical and environmental isolates in Brazil [ 29 ] and 92.2% TMP-SXT resistant isolates were also identified in hospital waste effluent in Denmark [ 30 ]. Similarly, high antibiotic resistance percentage were also found in Bangladesh from isolates collected from endotracheal tube with 100% resistance for ceftriaxone and gentamicin, and 66.7% for amikacin and impenem 66.7% [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Solomon

Wadilo

Tufa

et al. 2017

Antimicrob Resist Infect Control

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BackgroundFrequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment. The aim of this study was to determine the prevalence and pattern of antibiotic resistance, extended spectrum and metallo beta-lactamase producing P. aeruginosa and A. baumannii isolates from restricted settings of indoor air hospital environment.MethodsA hospital-based cross-sectional study was conducted in Wolaita Sodo University Teaching and referral Hospital, Ethiopia from December 1/2015 to April 30/2015. The Air samples were collected from delivery room, intensive care unit and operation theatre of the hospital by active, Anderson six slate sampler technique during the first week of the months, twice a week during Monday’s and Friday’s. Standard microbiological procedures were followed to isolate P. aeruginosa and A. baumannii. Susceptibility testing was performed on isolates using the Kirby-Bauer disk diffusion technique. Extended spectrum beta lactamase production was detected by double disc synergy test and Imipenem-resistant isolates were screened for producing Metallo-beta lactamase.ResultsA total number of 216 indoor air samples were collected from the delivery room, intensive care unit, and operation room. Correspondingly, 43 A. baumannii isolates were identified (13 from delivery room, 21 from intensive care unit and 9 from operation room). Likewise 24 P. aeruginosa isolates were obtained (4 from delivery room, 13 from intensive care unit and 7 from operation room). Extended spectrum beta lactamase and metalo-beta lactamase production were observed in 24 (55.8%) and 13 (30.2%) isolates of A. baumannii respectively, whereas P. aeruginosa showed 15 (62.5%) extended spectrum beta lactamase and 9 (37.5%) metallo-beta lactamase production.ConclusionsExtended spectrum beta lactamase and metallo-beta lactamase producing bacteria in hospital air is a new dimension for specific setting of the study area where antimicrobial resistance is increasing and surgical site infection is prevalent. So, identification of these microorganisms has a great role in reducing the burden of antibiotic resistance and could also provide a significant input for framing hospital infection control policies.

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Section: Discussionmentioning

confidence: 99%

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Solomon

Wadilo

Tufa

et al. 2017

Antimicrob Resist Infect Control

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“…Os mecanismos de resistência do A. baumannii podem ter origem intrínseca ou adquirida e são mediados por diversos fatores, como perda da permeabilidade da membrana e, mais expressivamente, produção de betalactamases, enzimas que degradam antibióticos betalactâmicos, sendo a principal causa de resistência bacteriana 9 . Carbapenemases representam o grupo mais versátil de beta-lactamases, devido ao seu amplo espectro de ação.…”

Section: Mecanismos De Resistênciaunclassified

“…As regiões sul e sudeste do país apresentam maior incidência de cepas multirresistentes deste microrganismo 9 23 .…”

Section: Aspectos Epidemiológicosunclassified

Acinetobacter baumannii Multirresistente: Aspectos Clínicos e Epidemiológicos

Vieira

Picoli

2015

Rev. bras. ciênc. Saúde

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RESUMO Objetivos: Demonstrar o perfil clínico e epidemiológico das infecções associadas à Acinetobacter baumannii produtor de carbapenemases, com enfoque nos relatos descritos no Brasil. Material e Métodos: Este estudo consiste em uma revisão bibliográfica, na qual foram avaliados artigos originais e artigos de revisão publicados em português ou em inglês entre 2001 e 2013. Após consulta às bases de dados eletrônicas Pubmed/MEDLINE e SciELO mediante o emprego dos descritores "Acinetobacter baumannii", "carbapenemases", "infecção", "epidemiologia", 33 artigos foram selecionados para análise. Resultados: A. baumannii é um patógeno oportunista comumente associado a surtos de infecções nosocomiais, incluindo pneumonia associada à ventilação mecânica, com incidência mais elevada em unidades de terapia intensiva (UTIs). A habilidade deste patógeno em desenvolver mecanismos de resistência limita a disponibilidade de opções terapêuticas, dificultando o tratamento destas infecções e elevando os índices de mortalidade. Metalo-beta-lactamases e, mais prevalentemente, oxacilinases são a causa mais preocupante de resistência adquirida a carbapenens neste patógeno. O primeiro surto relatado no Brasil ocorreu em 1999 e, desde então, houve uma crescente disseminação de clones epidêmicos desta bactéria no país. Conclusão: A emergência mundial de cepas de A. baumannii multirresistentes produtoras de carbapenemases tem se tornado um problema de saúde pública. Portanto, o desenvolvimento de novas opções terapêuticas e a maior ênfase na prevenção de transmissão desta bactéria em meio hospitalar são essenciais. DESCRITORES Acinetobacter baumannii. Beta-Lactamases. Infecção. Epidemiologia.

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“…OXA-143 is still little studied and restricted to Brazil. It was identified in a clinical isolate of multidrug-resistant A. baumanni [26][27][28][29]. β-lactamase OXA-143 hydrolyzes penicillins and carbapenems but does not significantly hydrolyze expanded-spectrum cephalosporins, as observed with other carbapenem-hydrolyzing class D-β-lactamase [26].…”

Section: Introductionmentioning

confidence: 98%

Epidemiological characteristics and antimicrobial susceptibility among carbapenem-resistant non-fermenting bacteria in Brazil

Dias¹,

Diniz²,

Peter

et al. 2016

J Infect Dev Ctries

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Introduction: Non-fermenting Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are widespread in the environment and are increasingly associated with nosocomial infections. Extensive and indiscriminate use of antibiotics in hospitals has contributed to an increased number of infections caused by these microorganisms, that are resistant to a wide variety of antimicrobials, including β-lactams. This study aimed to isolate and identify carbapenem-resistant Acinetobacter spp. and P. aeruginosa from hospitalized patients, to determine their antimicrobial susceptibility patterns and to screen for blaOXA , and blaOXA-143 genes among the isolated bacteria. Methodology: Antimicrobial resistance patterns were performed using the disk-diffusion method. Genetic markers related to carbapenem resistance were screened by polymerase chain reaction. Results: Carbapenem-resistant Acinetobacter spp. (n = 44) and P. aeruginosa (n = 28) samples were isolated from patients admitted to a tertiary hospital. Polymyxin B was the only effective drug for all isolates. Considering the oxacillinase gene screening, genetic markers were observed only in Acinetobacter isolates. The most frequent genotype observed was blaOXA-23 + /blaOXA-51 + (45.5%), followed by blaOXA-51 + /blaOXA-143

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Oxacillinase (OXA)-producing Acinetobacter baumannii in Brazil: clinical and environmental impact and therapeutic options

Abstract: Following a worldwide trend, infections caused by MDR OXA-type (Ambler class D) carbapenemase-producing Acinetobacter baumannii are currently regarded as a clinical and epidemiological emergency in Brazil. OXA-producing A. baumannii strains have been identified in the states of Alagoas,

Cited by 15 publications

References 134 publications

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Acinetobacter baumannii Multirresistente: Aspectos Clínicos e Epidemiológicos

Epidemiological characteristics and antimicrobial susceptibility among carbapenem-resistant non-fermenting bacteria in Brazil

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