Prevalence of sickle cell trait in dialysis patients

Isaias, Luana; Bertoni, Suzane; Santos, Ana Luiza Barbosa dos; Ribeiro, Esperança da Luz Tinoco; Borsato, Lívia; Kang, Hye Chung

doi:10.1590/s1676-24442013000400006

J. Bras. Patol. Med. Lab.

2013

DOI: 10.1590/s1676-24442013000400006

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Prevalence of sickle cell trait in dialysis patients

Luana Isaias¹,

Suzane Bertoni²,

Ana Luiza Barbosa dos Santos³

et al.

Abstract: The sickle cell nephropathy is described as a homozygous sickle cell disease. However, there is no consensus as to the heterozygotes, thus other investigations are required to provide further information on this topic. This study aimed at determining the frequency of sickle cell trait in a population of chronic renal failure patients in the city of Niterói.

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2018

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The sickle cell trait and end stage renal disease in Salvador, Brazil

et al. 2018

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BackgroundCarriers of the sickle cell trait (HbAS) usually remain asymptomatic. However, under conditions of low tissue oxygenation, red blood cell sickling and vascular obstruction may develop. Chronic kidney disease (CKD) can arise from conditions promoting low-oxygen in kidney tissue, which may be aggravated by the presence of the sickle cell trait. In addition, CKD can arise from other genetic traits.AimTo compare the frequency of HbAS among hemodialysis patients and the general newborn population of Salvador (Bahia-Brazil), as well as to investigate the frequencies of apolipoprotein L1 risk variants in patients undergoing hemodialysis.MethodsA cross-sectional study included 306 patients with ESRD (End Stage Renal Disease) on hemodialysis for no more than three years. Hemoglobin profiles were characterized by high-performance liquid chromatography. To estimate the sickle cell trait frequency in the general population of Salvador, we analyzed data collected by a local neonatal screening program between 2011 and 2016. To exclude the potential contributing effect of the apolipoprotein L1 (APOL1) gene variants, we performed genotyping by PCR and DNA sequencing of 45 patients.ResultsThe frequency of HbAS was significantly higher in hemodialysis patients (9.8%) than in the general population (4.6%): Odds Ratio = 2.32 (95% CI = 1.59–3.38). No differences in demographic, clinical or laboratory data were found among patients with or without the sickle cell trait. The frequency of patients with none, one or two APOL1 risk haplotypes (G1 and G2) for CKD were 80%, 18% and 2%, respectively.ConclusionsThe frequency of the sickle cell trait is higher in patients with ESRD on hemodialysis compared to the general population. APOL1 haplotypes do not seem to be the determinant of ESRD in these patients.

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The sickle cell trait and end stage renal disease in Salvador, Brazil

et al. 2018

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Prevalence of sickle cell trait in dialysis patients

Cited by 1 publication

References 4 publications

The sickle cell trait and end stage renal disease in Salvador, Brazil

The sickle cell trait and end stage renal disease in Salvador, Brazil

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