Epidemiologia das betalactamases de espectro estendido no Brasil: impacto clínico e implicações para o agronegócio

Silva, Ketrin Cristina da; Lincopán, Nilton

doi:10.1590/s1676-24442012000200004

Cited by 51 publications

(45 citation statements)

References 59 publications

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“…Bloodstream infections (BSIs) were strongly associated with mortality (OR: 16.3252; p-value = 0.0122), which concurs with previous investigations into P. aeruginosa bacteremia (16) (18) (19) . The incidence of BSIs in patients who are hospitalized in ICUs ranges from 9% to 31%, and mortality rates vary according to symptom severity (8) (20) .…”

Section: Discussionsupporting

confidence: 88%

Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units

Matos

Conceição

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The spread of multidrug-resistant Pseudomonas aeruginosa in Brazilian hospitals has greatly impacted upon the morbidity and mortality of individuals in intensive care units. Given the lack of information regarding the dynamics of multidrug resistance in northern Brazil, we analyzed the clinical and microbiological features of nosocomial infections caused by P. aeruginosa. Methods: Between January 2010 and March 2012, we conducted a retrospective cohort study of P. aeruginosa isolates from 54 patients who were hospitalized in intensive care units. The clinical and epidemiologic variables were analyzed, including the patients' demographic data and comorbidities, and the lengths of the intensive care unit stays, the classification of the infections as nosocomial, the use of invasive procedures, antimicrobial therapy, and the patients' outcomes. We undertook susceptibility tests, molecular detection of the metallo-β-lactamase genes, and genotypic analyses of the isolates using the repetitive element-polymerase chain reaction. Results: Multidrug resistance occurred most frequently among isolates from adults who had been hospitalized for an average of 87.1 days. The use of mechanical ventilation and urinary catheters were risk factors for infection. The four isolates that harbored the blaSPM-1-like gene showed >95% genetic similarity. Conclusions: This study's findings show that P. aeruginosa has a high death rate, and that inadequate treatment and invasive procedures are risk factors for infection. This is the first report describing the detection of the blaSPM-1-like gene in northern Brazil. These results highlight the need for better monitoring and a greater understanding of nosocomial infections and their public health impacts.

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Section: Discussionsupporting

confidence: 88%

Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units

Matos

Conceição

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…In Rio de Janeiro, Brazil, strains of Klebsiella spp. Which produced ESBL from hospital effluents were also isolated (SILVA; LINCOPAN, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Despite the fact that the incidence of ESBL producing bacteria is higher in the clinical area, it is important to carry out the monitoring of strains propagated in food and water due to the exchange of genetic material among the resistant strains and the microorganisms of the host or the environment microbiota (SILVA; LINCOPAN, 2012 Lisboa, v. 108, n. 585-586, p. 39-43, 2013.…”

Section: Resultsmentioning

confidence: 99%

PROPAGATION OF ANTIMICROBIAL RESISTANT Salmonella spp. IN BIVALVE MOLLUSKS FROM ESTUARY AREAS OF BAHIA, BRAZIL

2016

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-In recent years, the emergence of resistant pathogens has complicated the treatment of bacterial infections in livestock production as well as in the medical field, due to the development of resistance mechanisms by microorganisms. The objective of this study was to delineate the antimicrobial resistance profile of Salmonella spp. strains isolated from bivalve mollusks (oysters and mussels) and from estuarine environment water of two regions of Bahia, Brazil. Twenty-seven strains, 12 isolated from bivalve mollusks and 15 from estuarine water, were tested. Eight antimicrobial agents (phenicol, beta-lactams, tetracyclines, quinolones and fluoroquinolones classes) were used for a susceptibility test, Minimum Inhibitory Concentration (MIC) and extended-spectrum beta-lactamases (ESBLs) production. Isolates showed high susceptibility to the classes of antimicrobial agents tested, with resistance only to nalidixic acid (27%), ampicillin (25%) and tetracycline (25%). Bacterial resistance was of chromosomal origin and the multidrug resistance index (MAR) among isolates of shellfish (mussels in natura) was 0.25. The MIC was found to be 100 µg/mL, 500 µg/mL and 350 µg/mL to nalidixic acid, ampicillin and tetracycline, respectively. None of the isolates presented ESBLs production. The presence of multidrug-resistant and high MIC Salmonella spp. is being conveyed in extraction areas of bivalve mollusks in the State of Bahia, Brazil.

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“…were found to be highly resistant to the combination of amoxicillin and clavulanic acid, which is unusual for ESBL producers. The chromosomal β-lactamases (AmpC) constitute another group of enzymes with a serine active site that are able to hydrolyze cephalosporins, and also confer microorganisms with resistance to inhibitors such as clavulanate, sulbactam, and tazobactam (18) . Drawz and Bonomo (19) reported that piperacillin is relatively resistant to hydrolysis through certain plasmid-mediated β-lactamases as compared with amoxicillin or ampicillin, which makes its combination with a β-lactamase inhibitor more effective.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

Rugini

Sobottka

Fuentefria

2015

Rev. Soc. Bras. Med. Trop.

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Epidemiologia das betalactamases de espectro estendido no Brasil: impacto clínico e implicações para o agronegócio

Abstract: Primeira submissão em 18/04/11 Última submissão em 13/01/12 Aceito para publicação em 14/02/12 Publicado em 20/04/12

Cited by 51 publications

References 59 publications

Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units

Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units

PROPAGATION OF ANTIMICROBIAL RESISTANT Salmonella spp. IN BIVALVE MOLLUSKS FROM ESTUARY AREAS OF BAHIA, BRAZIL

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

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