Nodular hyperplasia of Bartholin's gland: case reports and literature review

Abstract

reLato de caso case report

Bartholin’s Gland Bilateral Nodular Hyperplasia: A Case Report Study

“…In most of the reported cases, the lesions were unilateral (6) whereas in our case it was bilateral. A vast majority of cases reported symptoms like lower pelvic pain, signs or symptoms of Bartholin’s duct cyst, vulvar lumps, dyspareunia and painful masses (2, 4-8).…”

“…Tumors originating from the BGs are very rare ( 1 - 5 ). Duct cysts and inflammation are the more common lesions in these glands ( 1 , 3 - 6 ). Many solid masses that arise from the BGs are carcinoma ( 4 , 5 ).…”

“…Koenig and Tavassoli have established some criteria for differentiating NH and AD ( 4 ). Among benign solid lesions, nodular NH is the most common one ( 4 , 6 , 7 ). To the best of our knowledge, about 35 cases have been reported in the English literature so far ( 2 - 8 ).…”

A Bartholin's gland with nodules and cysts bathed in mucus

“…In older reports, the terms ‘adenoma’ and ‘hamartoma’ have been used for lesions that now are designated to be ‘nodular hyperplasia’ [2] , [3] , [4] , [5] . Reports with a histopathological perspective on nodular hyperplasia are scarce; we counted two larger series with 17 and 10 patients each [1] , [6] and five case reports with a total of 12 patients [2] , [7] , [8] , [9] , [10] . The excised glands, as offered to the histopathologist, had a mean maximum diameter of 2.3 cm (range 1.2–4 cm) in the report on 17 patients [1] and 2.4 cm (range 1.3–4.5 cm) in the report on 10 patients [6] .…”

“…The excised glands, as offered to the histopathologist, had a mean maximum diameter of 2.3 cm (range 1.2–4 cm) in the report on 17 patients [1] and 2.4 cm (range 1.3–4.5 cm) in the report on 10 patients [6] . Bilaterality was reported in 1 out of 27 patients in the larger case series [1] , [6] and in 5 out of 12 patients in the case reports [2] , [7] , [8] , [9] , [10] . Microscopically, an inspissated mucin and duct rupture with free mucus and mucus-laden macrophages in the stroma has been observed in the majority of the lesions.…”