Ghrelin and pre-proghrelin immunoreactive cells in gastric neuroendocrine tumors associated with atrophic body gastritis

Abstract

Primeira submissão em 26/03/10 Última submissão em 04/05/10 Aceito para publicação em 04/05/10 Publicado em 20/08/10 Ghrelin and pre-proghrelin immunoreactive cells in gastric neuroendocrine tumors associated with atrophic body gastritis Grelina e pré-progrelina em tumores neuroendócrinos do estômago associados à gastrite atrófica do corpo

Atrophic Body Gastritis: A Challenge for the Presumptive Endoscopic and Histologic Diagnosis of Autoimmune Gastritis

“…Both intestinal metaplasia and pseudoantral metaplasia were frequent findings in these patients with ABG. Among 60 patients with a diagnosis of ABG, 51 presented areas of pseudoantral metaplasia in the body atrophic mucosa and most of them, i.e., 37 (72.5%) presented ghrelin-immunoreactive endocrine cells in the wall of pseudoantral metaplastic glands (Moreira & Barbosa, 2011). This fact may be of help in the differentiation between antral and body mucosa in cases of ABG.…”

“…The endocrine cells of the oxyntic mucosa are spared from the process of atrophy, become hyperplastic what is commonly found in the ABG of autoimmune origin. Although these hyperplastic cells are considered to be enterochromaffin-like cells which are strongly reactive to the neuroendocrine marker chromogranin they can also express immunoreactivity to some peptide hormones such as ghrelin (Moreira et al 2010). .…”