Importância clínica e laboratorial do volume plaquetário médio

Farias, Mariela Granero; Bó, Suzane Dal

doi:10.1590/s1676-24442010000400003

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…The reference values for the MPV found in this study were similar to the values found in 580 Brazilian participants in the ELSA-Brazil study 7 and 1670 healthy Danish individuals 9 [10.5 fL (8.9–12.2), using the Sysmex XE 5000, and 10.5 fL (8.9–12.2), using the Sysmex XE 2100 D, respectively]. Regarding the PDW, the values obtained in our study were very similar to those previously reported in 231 Brazilian subjects 10 [13.3% (10.0–17.9)], using the Pentra 120 analyzer (Horiba Medical, France) and in 816 healthy South Korean pregnant women at 20 weeks of gestation 11 [PDW 11.6% (8.9–15.5)]. In regard to the PCT, our results are comparable to those previously described in 565 healthy pregnant Chinese women, 0.17% (0.12–0.27) using a Coulter 780 5Diff analyzer (Beckman Coulter, USA) 12 ; and in 945 healthy blood donors in India, whose reported interval was 0.15–0.62%, using a Sysmex XE 2100 D (Sysmex, Japan) 13 .…”

supporting

confidence: 91%

Reference intervals of the platelet indexes in a healthy population in Santa Maria, Rio Grande do Sul, Brazil

Pereira

Carvalho

Paniz

2019

Hematology, Transfusion and Cell Therapy

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supporting

confidence: 91%

Reference intervals of the platelet indexes in a healthy population in Santa Maria, Rio Grande do Sul, Brazil

Pereira

Carvalho

Paniz

2019

Hematology, Transfusion and Cell Therapy

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“…Therefore, new data to evaluate and describe controlled results in animals with haemonchosis are necessary. Thrombograms allow evaluating hemostasis disorders, contributing to the diagnosis and prognosis of different pathologies (FARIAS;BÓ, 2010). In this study, the thrombograms were similar between treatments and evaluation periods, with platelet averages ranging from 420 to 586 (10³/ µL).…”

Section: Discussionmentioning

confidence: 56%

Blood parameters of sheep with high infection of Haemonchus contortus and treated with “mushroom of the sun” (Agaricus blazei)

et al. 2016

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Parâmetros sanguíneos de ovinos com alta infecção porHaemonchus contortus e tratados com "cogumelo do sol" (Agaricus blazei) AbstractBlood and parasitological parameters of sheep experimentally infected with Haemonchus contortus and treated with "mushroom of the sun" (Agaricus blazei) were assessed. Lambs infected with the nematode were divided into three groups: treated with basidiocarp powder from the fungus, wormed with trichlorfon, and a control group that did not receive anthelmintic. Split-plot design analysis was performed where the treatments were defined as plots and four periods of collection were defined as subplots. Interaction between the treatments and the collection periods for the fecal egg counts per gram of feces (FEC) was observed. Treatment with "mushroom of the sun" showed anthelmintic efficacies ranging from 28.6 to 54.2%. Similar performances to weight gain were observed among the groups. A significant interaction between treatments and evaluation periods was observed for erythrocyte counts, hematocrit value, and serum concentrations of albumin and urea. The values of the mean corpuscular volume, erythrocyte distribution width, and leukocyte, neutrophil, lymphocyte, monocyte, and eosinophil counts, as well as the mean platelet volume, varied among the collection days. The administration of "mushroom of the sun" significantly reduced the FEC, did not influence on the erythrocyte count and hematocrit value, which remained within normal limits. However it increased the serum concentrations of albumin. com triclorfon e grupo controle, que não recebeu anti-helmíntico. Utilizou-se delineamento em parcelas subdivididas, sendo os tratamentos as parcelas e quatro períodos de coletas, as subparcelas. Verificouse interação dos tratamentos e dos períodos de coleta para o número de ovos por grama de fezes (OPG). O tratamento com "cogumelo do sol" apresentou eficácia anti-helmíntica variando de 28,6% a 54,2%, entretanto o desempenho foi semelhante entre os grupos. Verificou-se interação significativa dos tratamentos e os períodos avaliados para as contagens de eritrócitos, o valor do hematócrito e as concentrações séricas de albumina e ureia. Os valores do volume corpuscular médio, da amplitude de distribuição de eritrócitos, as contagens de leucócitos, neutrófilos, linfócitos, monócitos e eosinófilos, bem como o volume plaquetário médio variaram entre os dias de coleta. A administração do "cogumelo do sol" reduziu o OPG, não influenciou a contagem de eritrócitos e o valor do hematócrito, que estiveram dentro dos limites da normalidade, e aumentou significativamente as concentrações séricas de albumina. Palavras-chave: Agaricus blazei. Controle alternativo. Haemoncose. Ovinos. Perfil sanguíneo.

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“…Platelets (PLT) are directly or indirectly involve in the processes of chronic complications in T2DM [2,3] . Larger platelets are more active and more tend to aggregate compared to smaller non-reactive platelets [4,5] . Platelets with altered size and shape have been suggested as associated with higher risk of diabetic complications [6] .…”

Section: Introductionmentioning

confidence: 99%

Is Mean Platelet Volume to Platelet ratio a promising indicator of diabetic regulation in type 2 diabetes mellitus?

Duman¹,

Aktaş²,

Tel³

et al. 2018

J. Med. Res.

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Aims: Type 2 diabetes mellitus (T2DM) is associated with great disease burden since it has high prevalence, morbidity and mortality rates. Platelets (PLT) are directly or indirectly involve in the processes of chronic complications in T2DM. Beside serving as a marker of platelet activation, mean platelet volume (MPV) is also considered as an inflammatory indice. A MPV to PLT ratio (MPR) is introduced as a novel inflammatory predictor and a marker of worse outcome, recently. We aimed to study MPR levels of type 2 diabetic patients in present report. Methods: Subjects older than 18 years old and with type 2 diabetes mellitus treated in outpatient internal medicine clinics of our university hospital during June 2017 to December 2017 were included. Medical data of the patients obtained from computerized database of the institution analyzed retrospectively. General characteristics and laboratory parameters of the participants, were compared to those in healthy controls. Results: We found significantly increased MPR in diabetic subjects compared to healthy volunteers (p=0.02). Moreover, MPR and fasting blood glucose (r=0.264, p<0.001), and MPR and HbA1c (r=0.234, p=0.003) were significantly and positively correlated (r=0.234, p=0.003). Conclusion: We suggest that, elevated MPR in otherwise healthy subject should courage physicians for prompt evaluation for type 2 DM. Correlations between MPR and fasting plasma glucose and HbA1c need validation with further studies with larger population.

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Importância clínica e laboratorial do volume plaquetário médio

Cited by 10 publications

References 53 publications

Reference intervals of the platelet indexes in a healthy population in Santa Maria, Rio Grande do Sul, Brazil

Reference intervals of the platelet indexes in a healthy population in Santa Maria, Rio Grande do Sul, Brazil

Blood parameters of sheep with high infection of Haemonchus contortus and treated with “mushroom of the sun” (Agaricus blazei)

Is Mean Platelet Volume to Platelet ratio a promising indicator of diabetic regulation in type 2 diabetes mellitus?

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