Neocolagenização induzida pelo resurfacing com laser erbium:YAG isolado e associado a lifting cutâneo: estudo morfométrico comparativo em ratos

Noronha, Lúcia de; Figueroa, Maria Cristina; Tamanini, Paloma Rincón; Graf, Ruth

doi:10.1590/s1676-24442005000500008

Cited by 1 publication

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References 13 publications

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“…The choice of the skin of Wistar rats for this study was carried out based on previous studies on peeling which using damage induced by laser resurfacing procedure [29]. No evidence of irritation or erythema was observed in most animals following the application of 50% glycolic acid gel, confirming that the procedure was not aggressive.…”

Section: Resultsmentioning

confidence: 99%

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Gonçalves¹,

Barros²,

Silva³

et al. 2017

JCDSA

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Plant-derived substances such as curcumin and trans-resveratrol, both of which have anti-inflammatory properties, may have a beneficial effect on human skin. The present study analyzed the effects of topical formulations containing curcumin or trans-resveratrol on the recovery and rejuvenation of skin after chemical peeling. The study was performed on rats, randomly divided into seven groups of six animals each. Superficial peeling was performed using a 50% glycolic acid gel, which was applied to the dorsal region of each animal. Rats were then treated with the experimental formulations for 15 days. On the sixteenth day, skin samples were taken and mounted on slides for histological analysis. Statistical analysis showed that the formulation containing transresveratrol led to increased dermal and epidermal thickness, while the formulation containing curcumin had no effects on epidermal thickness. The increased epidermal thickness may reflect greater skin vitality, although this was not directly evaluated. The increase in dermal thickness may be attributed to greater collagen production, which may increase skin firmness and elasticity, and lead to skin rejuvenation as well as wrinkle reduction. Formulations containing curcumin or trans-resveratrol may have potential for the topical treatment after peeling and of sensitive skin, in addition to being used for their antiaging properties.

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Section: Resultsmentioning

confidence: 99%