Genotoxicity investigation of araticum(Annona crassiflora Mart., 1841, Annonaceae) using SOS-Inductest and Ames test

Vilar, Juliana Brandstetter; Ferri, Pedro Henrique; Chen-Chen, Lee

doi:10.1590/s1519-69842011000100028

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…In contrast, Vilar et al (2011) were unable to detect genotoxic or mutagenic activities of ethanolic extract of leaves of A. crassiflora using prophage λ induction (SOS-Inductest) and bacterial mutagenicity (Ames test) assays. This divergence may have resulted from the type of organisms employed in the tests, in that our study involved eukaryotes while that of Vilar et al (2011) employed prokaryotes.…”

Section: Discussionmentioning

confidence: 91%

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

et al. 2013

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Infusions of the leaves and seeds of Annona crassiflora Mart. are commonly employed in the treatment of diarrhoea, snakebites, tumours and disorders of the hair and scalp. The aim of the present study was to investigate the cytotoxic and genotoxic properties of ethanolic extracts of A. crassiflora by evaluating their effects on germination, root elongation, chromosome structure and the cell division of Lactuca sativa (lettuce). The experiment followed a randomized design involving the treatment of L. sativa seeds with ethanolic extracts from leaves and seeds of A. crassiflora applied at ten concentrations (0.0125, 0.025, 0.05, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0, and 1.2 mg/L) and with five repetitions per treatment. Seeds of L. sativa exposed for 48 h to A. crassiflora leaf extract at concentrations ≥ 0.1 mg/L, or to seed extracts at concentrations ≥ 0.2 mg/L, showed germination percentages that were significantly (p < 0.05) lower than those of seeds exposed to aqueous ethanol control. Exposure of L. sativa seedlings to leaf (but not seed) extracts of A. crassiflora produced significant (p < 0.05) reductions in the mitotic indices of root meristem cells of lettuce and induced chromosome and nuclear abnormalities in the root cells. The presence of chromosome stickiness, bridges, fragments, laggard chromosomes and nuclear condensation were also observed. The cytogenetic effects observed suggest that folkloric medicines prepared with extracts of the leaves or seeds of A. crassiflora should be employed with caution.

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Section: Discussionmentioning

confidence: 91%

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

et al. 2013

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“…Annona fruits are tasty, with a sweet, creamy flesh and fragrant flavor when fully ripe (Pareek et al, 2011) in addition to presenting bioactive components with medicinal potential (Vilar et al, 2008(Vilar et al, , 2011Quílez et al, 2018). However, the development of seedless varieties of these plants adapted to Brazilian conditions remains limited (Pereira et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Inheritance of seedlessness and the molecular characterization of the INO gene in Annonaceae

et al. 2023

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The inheritance of the seedless fruit characteristic of Annona squamosa has not yet been explained. Molecular techniques may aid breeding programs, mainly in the assisted selection of the target gene. The INO gene may be related to seed development in these fruits. The objective of the present paper was to investigate the inheritance of seedlessness in the 'Brazilian seedless' sugar apple and INO gene conservation in Annona squamosa and Annona cherimola x Annona squamosa genotypes by assessing their homology with the INO database genes. The F1 generation was obtained by crossing the mutant 'Brazilian seedless' (male genitor) (P1) with the wild-type A. squamosa with seeds (M1 and M2, female genitors). The INO gene was studied in mutant and wild-type A. squamosa (P1, M1, M2 and M3) and in the Gefner atemoya (A. cherimola x A. squamosa) (M4) cultivar. The DNA was extracted from young leaves, and four sets of specific primers flanking the INO gene were amplified. The seedless characteristic was identified as stenospermatic in the fruits of parental P1, suggesting monogenic inheritance with complete dominance. High sequence similarity of the INO gene amplifications in the sugar apple accessions (M1, M2, M3) and the atemoya cultivar Gefner (M4) reinforces the hypothesis of their conservation.

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“…[14–16] A few studies have discussed the “timing” factor in the harvest of plant materials, in the preparation, and the administration of the herbal concoctions. [1718] Yet this factor may play an important role in the diagnosis, treatment, healing, and poisoning associated with taking medication.…”

Section: Introductionmentioning

confidence: 99%

Medicinal plants use in central Togo (Africa) with an emphasis on the timing

Tchacondo¹,

Karou²,

Agban³

et al. 2012

Phcog Res

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Background:Plant-based remedies continue to play a key role in the health care of people in Togo; however, there is a lack of published data in medicinal plants and medical practices of the people in the country.Objective:This study was aimed at documenting the plant utilization in the Tem folk medicine in the central region of Togo.Materials and Methods:An ethnobotanical survey was conducted with traditional healers in the central region of Togo using a semi-structured questionnaire.Results:This study demonstrated that local specialists in the central region of Togo tend to agree with each other in terms of the plants used to treat diabetes (ICF = 0.38), infertility, and abdominal pains (ICF = 0.33), but cite a much more diverse groups of plants to treat problems related to arterial hypertension, sickle cell disease, and abscess. They use 144 herbal concoctions made of 72 plants, distributed among 36 botanical families. The Euphorbiaceae family with eight species was best represented in terms of the number of species. The species with the highest use value were Khaya senegalensis (Desr.) A. Juss. (Meliaceae) (UV = 0.36), Anthocleista djalonensis A. Chev. (Gentianaceae) (UV = 0.27), Trichilia emetica Vahl (Meliaceae) (UV = 0.25), and Sarcocephalus latifolius (Sm.) E. A. Bruce (Rubiaceae) (UV = 0.21). They also rely on the timing in the plant processing and the administration of herbal remedies.Conclusion:All these findings are based on empirical observations; laboratory screenings are needed to check the effectiveness of these plants.

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Genotoxicity investigation of araticum(Annona crassiflora Mart., 1841, Annonaceae) using SOS-Inductest and Ames test

Cited by 14 publications

References 25 publications

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

Inheritance of seedlessness and the molecular characterization of the INO gene in Annonaceae

Medicinal plants use in central Togo (Africa) with an emphasis on the timing

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