Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Pa, Polo; Ro, Reis; Pl, Cedraz-Mercez; Hr, Cavalcante-Lima; El, Olivares; Ma, Medeiros; Côrtes, WS; Lc, Reis

doi:10.1590/s1519-69842007000100023

Cited by 10 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…236 It was once thought that serotonin was incapable of crossing the BBB, however more recent research demonstrates otherwise. [237][238][239] The results of earlier studies may have been due to a lack of active gene expression in cell culture.…”

Section: Amino Acids and Biogenic Amines Serotonylationmentioning

confidence: 99%

Advances in Nutritional Epigenetics—A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions

Sedley

2020

Genet Epigenet

View full text Add to dashboard Cite

Nutritional epigenetics is a rapidly expanding field of research, and the natural modulation of the genome is a non-invasive, sustainable, and personalized alternative to gene-editing for chronic disease management. Genetic differences and epigenetic inflexibility resulting in abnormal gene expression, differential or aberrant methylation patterns account for the vast majority of diseases. The expanding understanding of biological evolution and the environmental influence on epigenetics and natural selection requires relearning of once thought to be well-understood concepts. This research explores the potential for natural modulation by the less understood epigenetic modifications such as ubiquitination, nitrosylation, glycosylation, phosphorylation, and serotonylation concluding that the under-appreciated acetylation and mitochondrial dependant downstream epigenetic post-translational modifications may be the pinnacle of the epigenomic hierarchy, essential for optimal health, including sustainable cellular energy production. With an emphasis on lessons learned, this conceptional exploration provides a fresh perspective on methylation, demonstrating how increases in environmental methane drive an evolutionary down regulation of endogenous methyl groups synthesis and demonstrates how epigenetic mechanisms are cell-specific, making supplementation with methyl cofactors throughout differentiation unpredictable. Interference with the epigenomic hierarchy may result in epigenetic inflexibility, symptom relief and disease concomitantly and may be responsible for the increased incidence of neurological disease such as autism spectrum disorder.

show abstract

Section: Amino Acids and Biogenic Amines Serotonylationmentioning

confidence: 99%

Advances in Nutritional Epigenetics—A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions

Sedley

2020

Genet Epigenet

View full text Add to dashboard Cite

show abstract

“…Serotonin is present in gastrointestinal tract (GIT), acting on the enteric nervous system by controlling motor activity, regulating food intake, cell growth and glandular secretion (Hasler, ). Serotonin has also been shown to exert an effect on bird behaviour, observed in quails by Polo et al, ().…”

Section: Introductionmentioning

confidence: 88%

Histochemical and immunohistochemical adaptations on the gastroesophageal tube of the blue‐fronted parrot (Amazona aestiva Linnaeus, 1758)

2019

View full text Add to dashboard Cite

Amazona aestiva Linnaeus, 1758 is known as the blue‐fronted parrot. These animals are considered seed dispersion, contributing to ecological balance. Despite its ecological importance, A. aestiva is listed as an imminent danger of becoming extinct, as it is one of the most illegally traded native species in Brazil, besides losing its habitat due to deforestation and forest fires. The cranial oesophagus mucosa is lined with a non‐keratinized stratified squamous epithelium, and the basal layer presents melanocyte accumulation. No mucous glands were observed in the lamina propria/submucosa. The ingluvium two different muscular layer patterns were observed, one internal and circular and one very thick, external and longitudinal. The proventriculum submucosa consists of polygonal proventricular glands and contents into a broad central duct lined with simple columnar epithelium Periodic acid‐reactive Schiff positive (PAS+) and Alcian blue positive (AB+). The 5‐HT cells are dispersed in the proventricular glands located at base and apex. The ventricle mucous layer contains numerous branched folds lined by a simple columnar epithelium. The epithelium was negative reaction for PAS and positive for AB only on the fold surfaces. The 5‐HT cells were scarce and observed only at the base of the ventricular gland, as well as in the adjacent connective tissue.

show abstract

“…Another unique characteristic of the BBB of birds is the relatively high permeability to serotonin from the periphery, not observed in mammals [100]. In quail (Coturnix japonica), serotonin administered systemically elicited changes in behaviors that are centrally regulated, including feather bristling, crouching, eye closure, and sleep-like behavior [100], all suggesting a distinct role of the BBB in regulating behavior of birds.…”

Section: Unique Features Of the Avian Blood-brain Barriermentioning

confidence: 99%

Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Dunton

Göpel

et al. 2021

IJMS

View full text Add to dashboard Cite

The need to protect neural tissue from toxins or other substances is as old as neural tissue itself. Early recognition of this need has led to more than a century of investigation of the blood-brain barrier (BBB). Many aspects of this important neuroprotective barrier have now been well established, including its cellular architecture and barrier and transport functions. Unsurprisingly, most research has had a human orientation, using mammalian and other animal models to develop translational research findings. However, cell layers forming a barrier between vascular spaces and neural tissues are found broadly throughout the invertebrates as well as in all vertebrates. Unfortunately, previous scenarios for the evolution of the BBB typically adopt a classic, now discredited ‘scala naturae’ approach, which inaccurately describes a putative evolutionary progression of the mammalian BBB from simple invertebrates to mammals. In fact, BBB-like structures have evolved independently numerous times, complicating simplistic views of the evolution of the BBB as a linear process. Here, we review BBBs in their various forms in both invertebrates and vertebrates, with an emphasis on the function, evolution, and conditional relevance of popular animal models such as the fruit fly and the zebrafish to mammalian BBB research.

show abstract

Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Cited by 10 publications

References 17 publications

Advances in Nutritional Epigenetics—A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions

Advances in Nutritional Epigenetics—A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions

Histochemical and immunohistochemical adaptations on the gastroesophageal tube of the blue‐fronted parrot (Amazona aestiva Linnaeus, 1758)

Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Contact Info

Product

Resources

About