Ciclamato de sódio e rim fetal

Arruda, José Germano Ferraz de; Martins, Alex Tadeu; Azoubel, Reinaldo

doi:10.1590/s1519-38292003000200003

Cited by 5 publications

(4 citation statements)

References 22 publications

(21 reference statements)

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“…Given that the use of sucralose, one of the newest sweeteners of high sweetening power, has been gradually increasing, new studies are necessary to attest to its safe consumption. Recent studies have proven an association between ingestion of sweeteners and nephrotoxicity, hepatoxicity or retardation of placental and fetal development (Arruda et al, 2003;Portela & Azoubel, 2004;Martins et al, 2005;De Matos et al, 2006;Portela et al, 2007). RESUMEN: La sucralosa es un edulcorante artificial no nutritivo, 600 veces más dulce que la sacarosa, y es muy estable a altas temperaturas, entre otras características.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Sucralose in Humans: A Review

Rodero

Azoubel³

2009

Int. J. Morphol.

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Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a diffusion, through the placental barrier, of small doses of sucralose and its metabolites. Its hydrolysis products (4-CG e 1,6-DCF) are more rapidly absorbed than sucralose: 4-CG is excreted intact in the urine, and 1,6-DCF undergoes reduction with elimination by the urine or rapid conjugation with glutathione. Various organs can be affected by ingestion of high doses of sucralose. As a result of the rise in global consumption of sweeteners and light-or diet-type products, studies are necessary to evaluate the action of this substance in the human species. The present study aims to accomplish a review of the literature that involves its indications of use, pharmacodynamics as well as the carcinogenic, teratogenic, neurotoxic, and nephrotoxic potentials of sucralose.

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Section: Discussionmentioning

confidence: 99%

Toxicity of Sucralose in Humans: A Review

Rodero

Azoubel³

2009

Int. J. Morphol.

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“…It has a taste profile very close to sucrose, presenting very low level of bitterness and sourness. The use of sucralose, one of the newest sweeteners of high sweetening power, has been gradually increasing [17]- [21].…”

Section: Introductionmentioning

confidence: 99%

Chemical, Nutritional and Organoleptical Characteristics of Orange-Based Formulated Low-Calorie Jams

Abolila¹,

Barakat²,

El-Tanahy³

et al. 2015

FNS

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Twelve low-calorie orange-based formulated jams were prepared mainly from orange, pumpkin and papaya, and then sweetened using fructose (F), stevioside (St) and sucralose (Su). The nutritional value of formulated jams was estimated after the approximate chemical composition and total soluble solid have been determined. The effect of storage on total phenolic compounds, antioxidant capacity, carotenoids content and vitamin C was investigated. Organoleptical attributes of prepared low-calorie jams were done as well. Results indicated that the nutritive value [kcal 100 g −1 fw] ranged from 88.10 ± 0.60 to 164.34 ± 0.41; total phenol content (TPC, mg GAE 100 g −1 fw] ranged from 188.52 ± 2.45 to 411.79 ± 3.3; the antioxidant capacity (μmol TE g −1 fw) ranged from 14.57 ± 0.86 to 32.39 ± 1.19; total carotenoids [mg 100 g −1 fw] ranged from 115.20 ± 5.66 to 204.33 ± 4.21; vitamin C [mg 100 g fw] ranged from 8.94 ± 1.07 to 28.77 ± 4.46; total soluble solids [Brix] ranged from 22.53 ± 0.05 to 43.37 ± 0.13. Jams storage for a period of 12 months at room temperature led to a decrease in vitamin C content, TPC, antioxidant capacity, while total soluble solids (TSS) and carotenoids increased during storage. The results of organoleptical attributes showed that the formulas O11, O1 had the highest score of color and odor respectively while O7 recorded maximum score for taste, texture and bitterness respectively. Statistical analysis showed that storage intervals and treatments had a significant (p < 0.05) effect on sensory quality of diet jam. The organoleptical characteristics were affected with the extension of shelf-life. Addition of stevioside and sucralose to formulate the low-calorie jam increased total phenol and antioxidant capacity, improved color, taste and produced targeted low-calorie jams. The use of sweeteners such as fructose, sucralose and stevioside in the manufacture of orange diet jam was shown to be satisfactory, resulting in low-calorie jams, improved the quality and could be produced commercially.

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“…It is known that the majority of sweeteners cross the placental barrier and are able to exert toxic effects on the fetus such as the toxicity of: sodium cyclamate to the fetal liver and kidneys (Arruda et al, 2003;Martins et al, 2005), aspartame to the fetal umbilical cord, placenta and liver (Portela et al, 2007), and aspartame to the fetal exocrine pancreas, umbilical cord and placenta (Leme & Azoubel, 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study

Rodero¹,

Batigália²,

Azoubel³

et al. 2010

Int. J. Morphol.

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SUMMARY:Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose, and experimental studies have suggested that the administration of some sweeteners, by diverse routes, retards not only fetal and placental development but also umbilical cord size. The present study aimed to estimate the fetal and placental weights and umbilical-cord length in fetuses from rat dams, after ingestion and non-ingestion of sucralose. In the treated group (5 dams), sucralose was administered (via gavage) at the dose of 30 mg/kg/day, from the 10th to 14th day of pregnancy. In the control group (5 dams), saline solution was administered, at the same dose and by the same route. On the 20th gestation day, both groups were sacrificed for weighing of the fetuses and placentas and measurement of umbilical-cord length. Mean values of fetal weight and umbilical-cord length of the treated group were significantly lower than controls (Mann-Whitney Test, p<0.001). Placental weight did not differ statistically between treated and control groups. It can be concluded from the present work that sucralose ingestion at 30 mg/ kg/day, from days 10 to 14 of pregnancy, diminished fetal weight and umbilical-cord length, which suggests passage of sucralose through the placental membrane.

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Ciclamato de sódio e rim fetal

Cited by 5 publications

References 22 publications

Toxicity of Sucralose in Humans: A Review

Toxicity of Sucralose in Humans: A Review

Chemical, Nutritional and Organoleptical Characteristics of Orange-Based Formulated Low-Calorie Jams

Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study

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