Cholesterol and prevention of atherosclerotic events: limits of a new frontier

Abstract

Control of atherosclerotic cardiovascular disease – a highly prevalent condition and one of the main causes of mortality in Brazil and worldwide – is a recurrent subject of great interest for public health. Recently, three new guidelines on dyslipidemia and atherosclerosis prevention have been published. The close release of these important publications is a good opportunity for comparison: the Brazilian model has greater sensitivity, the English model does not work with risk stratification, and the American model may be overestimating the risk. This will allow reflection on current progress and identification of controversial aspects which still require further research and debate. It is also an opportunity to discuss issues related to early diagnosis and its efficiency as a preventive strategy for atherosclerotic disease: the transformation of risk into disease, the gradual reduction of cut-off points, the limitations of the screening strategy, and the problem of overdiagnosis.

Resistant hypertension: Prevalence and profile of patients followed in a university ambulatory

“…In regard to clinical aspects, the higher prevalence of DM ( p = 0.003) and dyslipidemia in patients with RH in relation to patients with hypertension suggests a higher cardiovascular risk (CVR) related to RH. 35 , 36 Furthermore, the use of statins was more common among patients with RH, which may also be related to the elevated CVR and renal dysfunction risk in this group. 37 Although greater in the RH group, the difference between the prevalence of dyslipidemia in the two groups was lower than the difference found between the percentage of statin use.…”

Prevalência De Dislipidemia Em Indivíduos Atendidos No Laboratório De Um Hospital De Goiânia – Go

“…Neste estudo pode-se observar a maior prevalência de HDL-C baixo no sexo feminino, correlacionando com o estudo de Oliveira, et al 16 , que apresentou 91,38% de mulheres com HDL-C baixo. As concentrações séricas do HDL-C estão inversamente relacionadas ao risco de doença aterosclerótica, esta lipoproteína atua no transporte reverso do colesterol, como também exerce várias atividades como antioxidantes, anti-inflamatórias, vasodilatadoras entre outras 21 .…”