Human papillomavirus infection in women from Tlaxcala, Mexico

Abstract

Cervical cancer is an important health problem in women living in developing countries. Infection with some genotypes of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. Little information exists about HPV genotype distribution in rural and suburban regions of Mexico.Thus, we determined the prevalence of HPV genotypes in women from Tlaxcala, one of the poorest states in central Mexico, and we evaluated age infection prevalence and risk factors associated with cervical neoplasm. A cross-sectional study was conducted in 236 women seeking gynecological care at the Mexican Institute for Social Security in Tlaxcala, Mexico. Cervical scrapings were diagnosed as normal, low-grade, and high-grade squamous intraepithelial lesions (LGSIL, HGSIL). Parallel samples were used to detect HPV genotypes by PCR assays using type-specific primers for HPV 6, 11, 16, 18, and 31. An epidemiological questionnaire was applied. Prevalence of HPV infection was 31.3%. From the infected samples, prevalence of HPV 16 was 45.9%; HPV 18, 31.1%; HPV 31, 16.2%; HPV 6, 10.8%; HPV 11, 6.7%. With regard to age, the highest HPV prevalence (43.5%) was found in the 18-to 24-year-old group and the lowest (19%) in the 45-to 54-year-old group. None of the risk factors showed association with cervical neoplasia grade. HPV 16 was the most common in cervical lesions. HPV was present in 22% of normal samples and, of these, 82.6% represented high-risk HPVs. Tlaxcala showed HPV prevalence comparable to that of the largest cities in Mexico, with higher prevalence for HPV 31.

Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients

“…Interestingly, our pathological data demonstrate larger predominance of squamous cell carcinoma over adenocarcinomas in our samples, Furthermore the presence of HPV in benign cervical lesions has been widely documented. In our study, type specific HPV prevalence was similar to that found in aggregative analysis, where HPV 16/18 are the most frequent types observed (39, 40). …”

Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security

“…Therefore, our study population consisted of 2,956 women aged 18 to 70 years (mean age 43.7 ± 6.8 years). Partial data included in the present study has already been published (Pina-Sanchez et al, 2006;Velazquez-Marquez et al, 2009;Velazquez-Marquez et al, 2010;Pina-Sanchez et al, 2011).…”

“…Some studies concerning HPV in Mexico have shown some differences in the prevalence reported. Such differences range from 4.8% to 40.9% and suggest a variability of HPV frequencies regarding geographical zone (Torroella-Kouri et al, 1998;Gonzalez-Losa et al, 2004;Pina-Sanchez et al, 2006;Sanchez-Anguiano et al, 2006;Lopez-Revilla et al, 2008;Velazquez-Marquez et al, 2009;Canul-Canche et al, 2010;Illades-Aguilar et al, 2010;Orozco-Colin et al, 2010;Velazquez-Marquez et al, 2010).…”