Case report: disseminated dermatophytosis by microsporum gypseum in a systemic lupus erythematosus patient

Macêdo, Danielle Patrícia Cerqueira; Neves, Rejane Pereira; Lopes, Flávia Cadengue

doi:10.1590/s1517-83822008000100006

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…In recent times, infections caused by dermatophytes have assumed greater significance. The increasing number of patients with immunocompromised states, such as AIDS, diabetes mellitus, lupus, allergy, cancer and organ transplantation, has given these infections more prominence 5,18,20,28,37,38,56 . Reports of infections by non-dermatophytes has also received greater attention 4,7,34,51 .…”

Section: Resultsmentioning

confidence: 99%

Fungal agents in different anatomical sites in Public Health Services in Cuiabá, state of Mato Grosso, Brazil

Araújo

Fontes

Júnior

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIntroduction: A contribution to the regional epidemiological profile of the most common fungal agents in Public Health Services in Cuiabá, state of Mato Grosso, including university hospitals and polyclinics. Methods: Clinical specimens (n = 1,496) from 1,078 patients were collected, submitted to direct mycological exam (potash or stick tape method) and cultured in specific mediums. Dermatophytic and non-dermatophytic agents were identified according to micromorphology (Ridell technique). Results: The majority of the 1,496 specimens were skin (n = 985) and nail exams (n = 472). Of the 800 positive cultures, 246 (30.8%) corresponded to dermatophytes and 336 (42%) to yeasts of the genus Candida, 190 (23.7%) to other yeasts, 27 (3.4%) to non-dermatophytic filamentous fungi and one (0.1%) the agent of subcutaneous mycosis. Lesions considered primary occurred in greater numbers (59.5%) than recurrent lesions (37.4%), with a greater concentration of positivity occurring on the arms and legs. Conclusions: Comorbidities, allergies and diabetes mellitus were conditions associated with greater positivity in direct mycological exams and cultures. Positive culture was considered a definitive diagnosis of fungal infection and confirmed 47.8% of diagnostic hypotheses.

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Section: Resultsmentioning

confidence: 99%

Fungal agents in different anatomical sites in Public Health Services in Cuiabá, state of Mato Grosso, Brazil

Araújo

Fontes

Júnior

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…The clinical fungi identified in this work are mostly opportunistic. [38][39][40][41][42][43] The majority are mesophilic, with optimum growth temperatures ranging between 25 and 30°C. Only A. tubingensis is thermotolerant, able to grow at higher temperatures (37°C), although it is still capable of growing within the range of 25-30°C.…”

Section: Identification Of Fungal Strainsmentioning

confidence: 99%

Identification and characterisation of human pathogenic filamentous fungi and susceptibility to Thymus schimperi essential oil

Pagiotti

Angelini

Rubini³

et al. 2011

Mycoses

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Twenty-eight clinical fungal isolates were characterised by morphological (macro- and micro-features and growth response at 25, 30 and 37°C) and molecular (nuclear rDNA-internal transcriber spacer, calmodulin, cytochrome c oxidase 1 and the largest subunit of RNA polymerase II) analyses. The clinical fungal isolates were ascribed to the following taxa: Penicillium chrysogenum, Verticillium sp., Aspergillus tubingensis, Aspergillus minutus, Beauveria bassiana and Microsporum gypseum. In addition, in vitro susceptibility testing of the isolates to conventional antifungal agents and to two chemically well-defined chemotypes of Thymus schimperi essential oil was performed. Most of the isolates were resistant to amphotericin B (except A. minutus), and itraconazole, while terbinafine was quite active on these fungi. T. schimperi essential oil showed antifungal activity against all of the tested fungal isolates with minimal inhibitory concentration values similar or lower than those of terbinafine. Transmission electron microscopy analyses revealed that fungal growth inhibition by essential oil was accompanied by marked morphological and cytological changes.

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“…[4][5][6][7] In recent years, M. gypseum has emerged as an important cause of disseminated and recalcitrant tinea corporis infections in immunocompromised patients particularly in those with acquired immunodeficiency syndrome. [8][9][10][11][12] Humans infected with M. gypseum generally develop solitary lesions leading to inflammation and formation of kerion in advance stages with red raised and pustular plaques on any of the exposed area of glabrous skin and scalp. 13 Microsporum gypseum is also an aetiologic agent of dermatophytoses in animals.…”

Section: Introductionmentioning

confidence: 99%

“…Members of Microsporum gypseum complex representing a transition from the saprophytism to parasitism are frequent causes of dermatophytoses and have been isolated from various human and animal lesions 4–7 . In recent years, M. gypseum has emerged as an important cause of disseminated and recalcitrant tinea corporis infections in immunocompromised patients particularly in those with acquired immunodeficiency syndrome 8–12 . Humans infected with M .…”

Section: Introductionmentioning

confidence: 99%

Extracellular protease expression in Microsporum gypseum complex, its regulation and keratinolytic potential

Singh¹

2010

Mycoses

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Two soil isolates of Microsporum gypseum were studied for the production of extracellular proteases. Both the strains secreted protease on glucose-gelatin medium. The enzyme activity peaked on day 15 at 28°C. Asparagine repressed protease yield. Sugars caused catabolite repression of protease formation. Protease activities of both the isolates were significantly affected by incubation period, culture media and carbohydrates used. Both the strains grew on the skin bait and caused a gravimetrically measurable loss of the substrate. Despite less pronounced differences in the keratinase levels, great variations occured in the amount of keratin degraded by two isolates. Keratinase production as well as loss in substrate mass was better in glucose-lacking flasks than those containing the sugar. Although the rate of keratin degradation was independent of enzyme production, statistically positive correlations were recorded between loss in substrate mass: yielded dry mycelial weight and substrate degradation: keratinase levels.

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Case report: disseminated dermatophytosis by microsporum gypseum in a systemic lupus erythematosus patient

Cited by 4 publications

References 13 publications

Fungal agents in different anatomical sites in Public Health Services in Cuiabá, state of Mato Grosso, Brazil

Fungal agents in different anatomical sites in Public Health Services in Cuiabá, state of Mato Grosso, Brazil

Identification and characterisation of human pathogenic filamentous fungi and susceptibility to Thymus schimperi essential oil

Extracellular protease expression in Microsporum gypseum complex, its regulation and keratinolytic potential

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