Interference of tuberculosis on the performance of ELISAs used in the diagnosis of paratuberculosis in cattle

Lilenbaum, Walter; Ferreira, Renata Marques; Marassi, Carla Dray; Ristow, Paula; Oelemann, Walter; Fonseca, Leila de Souza

doi:10.1590/s1517-83822007000300016

Cited by 8 publications

(12 citation statements)

References 14 publications

(18 reference statements)

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“…Yet, when the individual results from the SIT or IGRA were analysed, a lack of association with JD positivity was observed, in contrast with previous studies 13 15 40 50 54. This could indicate that JD reactors were therefore not infected with M bovis , and therefore positivity in the JD-ELISA would not be due to cross-reactivity in M bovis- infected animals.…”

Section: Discussioncontrasting

confidence: 66%

Association between results of diagnostic tests for bovine tuberculosis and Johne's disease in cattle

et al. 2019

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BackgroundBovine tuberculosis (bTB) diagnosis is impaired by numerous factors including cross-reactivity with Mycobacterium avium subspecies paratuberculosis, which causes Johne’s disease (JD). In addition, the effect of repeated bTB-intradermal testing on the performance of JD diagnostic tests is not fully understood. This study aimed to evaluate the impact of repeated bTB-intradermal tests under field conditions in Spain on the JD serological status of cattle.MethodsbTB-positive herds (n=264) from Castilla-y-Leon region were selected and matched with officially tuberculosis-free control herds. The association between JD and bTB status at the herd level was assessed using conditional logistic regression and, in herds with both JD-positive and bTB-positive animals, a Bayesian hierarchical mixed-effect model was used for individual-level analysis.ResultsA significantly higher risk of being JD positive (OR: 1.48; 95 per cent CI: 1.01 to 2.15) was found for bTB-positive herds compared with controls. Individual results indicated that cattle tested more than three times per year, within the last 90 days and more than 12 months were more likely to be JD positive. A skin test-related boost in antibody response could be the cause of an apparent increase of the sensitivity of the JD-absorbed ELISA.ConclusionThe results demonstrate the interaction between bTB repeated testing and JD individual and herd-level results and this improved knowledge will facilitate the design of more effective control programmes in herds coinfected with two of the most important endemic diseases affecting cattle in Spain.

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Section: Discussioncontrasting

confidence: 66%

Association between results of diagnostic tests for bovine tuberculosis and Johne's disease in cattle

et al. 2019

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“…The Johnin skin test for paratuberculosis, which is interpreted as positive when skin thickness increased ≥4 mm, is a specific and low-cost test for the early diagnosis of paratuberculosis in the majority of dairy herds, although the specificity of both tests is influenced by batch of PPD antigen and varies among herds (Kalis et al 2003). Although very few studies (n=3) in the present review determined prevalences using this type of tests, previous information from Brazilian studies suggests that the intradermal tuberculin tests can interfere in the reliability of ELISA (Lilenbaun et al 2007(Lilenbaun et al , 2009Varges et al 2009) and that serological testing for PTB should be avoided for 90 days after PPD inoculation ). Studies on paratuberculosis in Latin America and the Caribbean rarely reported tuberculosis status or previous tuberculin tests before paratuberculosis testing, which could suggest that results could be higher than reported.…”

Section: Discussionmentioning

confidence: 77%

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Silva

Correa-Valencia

Ramı́rez

2014

Trop Anim Health Prod

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Mycobacterium avium subsp. paratuberculosis causes paratuberculosis or Johne's disease (JD) in domestic ruminants and wild species. The aim of the present study was to systematically review the prevalence of paratuberculosis among farmed animals (cattle, sheep, and goats) in Latin America and the Caribbean. The initial search for existing publications reporting systematic reviews and primary studies was carried out by searching the available databases. For the final selection of studies, an initial screen for basic eligibility and a detailed appraisal of quality were performed. After study selection, the relevant data were extracted. The detailed appraisal generated 24 publications that reported 52 studies, of which 73.1, 11.5, and 15.4 % were from cattle, sheep, and goats, respectively. Thirty-three (63.5 %) of the studies were animal level studies, while 19 (36.5 %) were herd-/flock-level studies. No flock-level studies on prevalence in sheep were found. Studies in Latin American and Caribbean countries revealed an overall prevalence of 16.9 (95 % CI (confidence interval) 13.2-20.5) and 75.8 % (95 % CI 50.1-101.5) in cattle at the animal and herd levels, respectively; the prevalence was 16 % (95 % CI 7.9-24.1) in sheep at the animal level and 4.3 % (95 % CI 1.9-6.8) and 3.7 % (95 % CI 0.1-7.4) in goats at the animal and flock levels, respectively. In general, prevalence results reported by the studies were insufficient to accurately determine the prevalence of paratuberculosis in farmed animals in Latin America and the Caribbean. Several flaws in the design of studies limit the quality of evidence regarding the prevalence of paratuberculosis in the region.

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“…This results in infected animals being reported as ELISA negative to MAP despite shedding MAP into the environment (Milner et al, 1987). False-positive humoral results can also arise due to bTB-infected animals, and bTB testing in herds before MAP testing without sufficient time elapsing between tests (i.e., 90 d; Lilenbaum et al, 2007;Varges et al, 2009). Environmental mycobacteria (closely related to, but excluding MAP) could also potentially result in false-positive ELISA results in the present study (Osterstock et al, 2007).…”

Section: Estimated Variance Components For Map In Comparison To Previmentioning

confidence: 75%

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

McGovern

Purfield

Ring

et al. 2019

Journal of Dairy Science

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Infection of cattle with bovine paratuberculosis (i.e., Johne's disease) is caused by Mycobacterium avium ssp. paratuberculosis (MAP) and results in a chronic incurable gastroenteritis. This disease, which has economic ramifications for the cattle industry, is increasing in detected prevalence globally; subclinically infected animals can silently shed the bacterium into the environment for years, exposing contemporaries and hampering disease-control programs. The objective of the present study was to first quantify the genetic parameters for humoral response to MAP in dairy cattle. This was followed by a genome-based association analysis and subsequent downstream bioinformatic analyses from imputed whole genome sequence SNP data. After edits, ELISA test records were available on 136,767 cows; analyses were also undertaken on a subset of 33,818 of these animals from herds with at least 5 MAP ELISApositive cows, with at least 1 of those positive cows being homebred. Variance components were estimated using univariate animal and sire linear mixed models. The heritability calculated from the animal model for humoral response to MAP using alternative phenotype definitions varied from 0.02 (standard error = 0.003) to 0.05 (standard error = 0.008). The genome-based associations were undertaken within a mixed model framework using weighted deregressed estimated breeding values as a dependent variable on 1,883 phenotyped animals that were ≥87.5% Holstein-Friesian. Putative susceptibility quantitative trait loci (QTL) were identified on Bos taurus autosome 1,

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Interference of tuberculosis on the performance of ELISAs used in the diagnosis of paratuberculosis in cattle

Cited by 8 publications

References 14 publications

Association between results of diagnostic tests for bovine tuberculosis and Johne's disease in cattle

Association between results of diagnostic tests for bovine tuberculosis and Johne's disease in cattle

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

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