Candida dubliniensis in a Brazilian family with an HIV 1- infected child: identification, antifungal susceptibility, drug accumulation and sterol composition

Melo, Nadja Rodrigues de; Taguchi, Hideaki; Culhari, Vitoria V.P.; Sano, Ayako; Fukushima, Kazutaka; Miyaji, Makoto; Manning, N. J.; Kelly, Steven L.; Vilela, Marluce S.

doi:10.1590/s1517-83822006000300008

Cited by 2 publications

(3 citation statements)

References 29 publications

(37 reference statements)

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“…C. dubliniensis has been frequently associated to oral and systemic candidiasis in HIV-positive patients 4,19,23 under chemotherapy and bone marrow transplant patients 3,18 , sometimes liable for death cases 28 . Thus, it is very important to identify among the population of immunossuppressed patients those who have C. dubliniensis in their oral microbiota, and how big is this ratio (cfu/mL).…”

Section: Discussionmentioning

confidence: 99%

“…C. dubliniensis has many phenotypic features with C. albicans and the incidence of candidemia due C. dubliniensis is unknown mainly because of difficulty in distinguishing these two strains 11 , 17 , 27 . C. dubliniensis has been frequently associated to oral and systemic candidiasis in HIV-positive patients 4 , 19 , 23 under chemotherapy and bone marrow transplant patients 3 , 18 , sometimes liable for death cases 28 . Thus, it is very important to identify among the population of immunossuppressed patients those who have C. dubliniensis in their oral microbiota, and how big is this ratio (cfu/mL).…”

Section: Discussionmentioning

confidence: 99%

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Presence of Candida spp. in the oral cavity of heart transplantation patients

Ribeiro¹,

Bacal²,

Koga-Ito

et al. 2011

J. Appl. Oral Sci.

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Candida spp. can lead to infections or even fungal sepsis particularly among immunocompromized individuals.ObjectiveThe aim of the present study was to analyze the presence of Candida spp. among patients subjected to orthotopic heart transplantation.Material and MethodsOral rinses from 50 patients subjected to orthotopic heart transplantation, aged 13 to 70 years, 40 males and 10 females, were examined. Sexage-oral conditions matched-control included 50 individuals who were not subjected to any kind of transplantation and were not immunocompromized for any other reason. Counts of yeasts were expressed as median values of logarithm of cfu/mL and were statistically compared by Mann-Whitney’s test. The heart transplant and control groups were compared for the presence of Candida spp. by chi-square test (p<0.05).ResultsThe results showed statistically significant difference (p=0.001) in the prevalence of Candida spp. between the transplantation and control groups. Counts of yeasts (cfu/mL) in the transplanted group were significantly higher than in the control group (p=0.005). Candida albicans was the most prevalent species isolated from both groups.ConclusionIt was concluded that Candida yeast counts were higher in the heart transplant recipients than in the controls. There was higher variation of Candida species among the heart transplant patients and the most frequently isolated samples were: Candida albicans, Candida glabrata and Candida tropicalis. Isolates of Candida dubliniensis was not found in either of the groups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Presence of Candida spp. in the oral cavity of heart transplantation patients

Ribeiro¹,

Bacal²,

Koga-Ito

et al. 2011

J. Appl. Oral Sci.

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“…In addition to these, there is C. dubliniensis, a more recently described species. It has been reported that this species has a virulence similar to that of C. albicans , due to their genomic similarity (36), and it is frequently isolated in HIV-positive patients (25). …”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of four Candida species induced by photogem®

Dovigo¹,

Pavarina²,

Ribeiro³

et al. 2010

Braz. J. Microbiol.

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This study evaluated the in vitro susceptibility of C. albicans, C. dubliniensis, C. tropicalis and C. krusei to photodynamic therapy (PDT) induced by Photogem®and light emitted diode (LED). Suspensions of each Candida strain were treated with three photosensitizer (PS) concentrations (10, 25 and 50 mg/L) and exposed to 18, 25.5 and 37.5 J/cm2 LED light fluences (λ ~ 455 nm). Control suspensions were treated only with PS concentrations, only exposed to the LED light fluences or not exposed to LED light or PS. Sixteen experimental conditions were obtained and each condition was repeated three times. From each sample, serial dilutions were obtained and aliquots were plated on Sabouraud Dextrose Agar. After incubation of plates (37 °C for 48 hours), colonies were counted (cfu/mL) and the data were statistically analyzed by ANOVA and the Tukey test (α=0.05). Complete killing of C. albicans was observed after 18 J/cm2 in association with 50 mg/L of PS. C. dubliniensis were inactivated after 18 J/cm2 using 25 mg/L of PS. The inactivation of C. tropicalis was observed after photosensitization with 25 mg/L and subsequent illumination at 25.5 J/cm2. For C. krusei, none of the associations between PS and light resulted in complete killing of this species. PDT proved to be effective for the inactivation of C. albicans, C. dubliniensis and C. tropicalis. In addition, reduction in the viability of C. krusei was achieved with some of the PS and light associations.

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Candida dubliniensis in a Brazilian family with an HIV 1- infected child: identification, antifungal susceptibility, drug accumulation and sterol composition

Cited by 2 publications

References 29 publications

Presence of Candida spp. in the oral cavity of heart transplantation patients

Presence of Candida spp. in the oral cavity of heart transplantation patients

Photodynamic inactivation of four Candida species induced by photogem®

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