Inhibitory activity of compounds isolated from Polymnia sonchifolia on aflatoxin production by Aspergillus flavus

Abstract

Polymnia sonchifolia, commonly known as "yacon", was originally cultivated at Andes moutains in South America. Recently, the specie attracted worldwide attention because of its wide range of uses, for example in the control of diabetes melitus, besides the antifungal and pesticidal compounds were found in the leaves. This study describes the identification of two flavonoids: 3', 5, 7 trihydroxy-3, 4'-dimethoxyflavone (compound 1) and 3', 4', 5-trihydroxy-7-methoxy flavanone (compound 2) and two sesquiterpenes lactones: enhydrin (compound 3) and a mixture of enhydrin and uvedalin (compound 4) isolated from Polymnia sonchifolia leaves and their effects on the aflatoxin production by Aspergillus flavus. The identification of the compounds were achieved by 1 H and 13 C NMR. All compounds were tested in different concentration, to evaluate the growth of Aspergillus flavus culture and the production of aflatoxin. The compound 1, at the concentration 15 μg/mL, inhibited 25% of the aflatoxin B1 production (p<0.01). The compound 4 inhibited 34% and 76% of the fungal growth and AFB1 production respectively. These results show that Polymnia sonchifolia can be used for the development of agents to control aflatoxin B1 production by Aspergillus flavus.

Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity

“…Polymnia sonchifolia] [2] was originally cultivated in South America where the tubers were used as a food crop and the aerial parts as fodder for livestock [3]. Yacon has antimicrobial [4], antifungal [5,6], antioxidative [7,8] and hypoglycaemic actions [9]. In 1990 in Japan, yacon leaves were investigated for their antimicrobial, antifungal and pest-resistant effects [10] and the following major compounds were isolated: sesquiterpene lactones, sonchifolin, uvedalin, enhydrin and fluctuanin.…”

Atividade anti-diabética, anti-inflamatória e toxicologia de Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson - Asteraceae

“…Adicionalmente, vários estudos têm demonstrado que a planta possui, ainda, promissoras atividades antifúngica, antibacteriana e anti-inflamatória (Inoue 1995;Pinto et al, 2001;Gonçalez et al, 2003;Lin et al, 2003;Pak et al, 2006;Schorr et al, 2007). Essas atividades parecem estar relacionadas principalmente à presença de lactonas sesquiterpênicas (LST) (Lin et al, 2003;Pak et al, 2006), as quais estão presentes em grandes quantidades nas folhas, sendo consideradas as substâncias majoritárias nesses órgãos (Inoue et al, 1995;Schorr & Da Costa, 2003).…”