Pathogenic aspects of Epidermophyton floccosum langeron et milochevitch as possible aethiological agent of Tinea capits

Macêdo, Danielle Patrícia Cerqueira; Neves, Rejane Pereira; Magalhães, Oliane Maria Correia; Souza-Motta, Cristina Maria de; Queiroz, L. A.

doi:10.1590/s1517-83822005000100007

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…Dermatophytes are evolved from soil residing keratinophilic organisms (Chuang et al, 2007). Dermatophytes cause infection mainly in hair, nails and skin and this disease can be mild or severe based on immune response of host cells (Abdel-Rahman, 2001; Macedo et al, 2005). Dermatophytes have the ability to produce proteolytic enzymes which are involved in hydrolyze of keratin (Akcaglar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

ANTIDERMATOPHYTIC ACTIVITY OF GREEN SYNTHESISED ZINC OXIDE NANOPARTICLES USING Cassia alata LEAVES

Sujatha¹,

Asokan²,

Rajeshkumar³

2018

J microb biotech food sci

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The green techniques are plying a major role in the synthesis of nanoparticles and in this present study we used the herbal plant Cassia alata for the green synthesis of zinc oxide nanoparticles. This reducing agent generates zinc oxide nanoparticles (ZnO NPs) from zinc acetate solution within 15 minutes. The synthesized ZnO NPs was characterized by UV-vis spectrophotometer shows surface Plasmon resonance band at 335 nm. Scanning electron microscope (SEM) image showed the size of the crystalline nanoparticles ranging from 30- 50 nm. Energy dispersive X-ray analysis (EDAX) confirms the presence of elemental Zn and O in the synthesized nanoparticles. FTIR revealed that presence of functional molecules like carboxylic acids, amine ant nitro groups associated with synthesized oxide nanoparticles. Atomic force microscope (AFM) shows spherical shape of nanoparticles as well as aggregation also observed. Thus green synthesized nanoparticles were tested for their antidermatophytic potential against Trichophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, Microsporum audouinii, and Microsporum canis and recorded percentage of inhibition, MIC and MFC values.

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Section: Introductionmentioning

confidence: 99%

ANTIDERMATOPHYTIC ACTIVITY OF GREEN SYNTHESISED ZINC OXIDE NANOPARTICLES USING Cassia alata LEAVES

Sujatha¹,

Asokan²,

Rajeshkumar³

2018

J microb biotech food sci

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“…Colonization by a dermatophyte, and its ability to cause an infection in the host, depends on several factors, among which are the “escape” mechanisms of the host resistance, including dry skin, a slightly acidic pH, the continuous regeneration skin, the fungicidal effect of fatty acids, the state of the keratinized layer and other factors, such as competition with the normal skin microbiota ( Erbagci et al , 2004 ). The establishment of the infection is initiated by the inoculation of arthrospores deposited on the skin, favored by a pre - existing skin lesion or abrasion ( Sidrim and Rocha, 2004 ) and the microorganism’s remarkable enzymatic ability to degrade keratin ( Simpanya, 2000 ; Abdel-Rahman, 2001 ; Macêdo et al , 2005 ). It also can infect several animal species, creating generally dry, rounded and usually non-pruritic lesions, distributed focally on the skin without causing a general inconvenience to the affected animals ( Pereira and Meireles, 2001 ; Sobestiansky, 2001 ).…”

Section: Dermatophytosismentioning

confidence: 99%

Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products

Soares¹,

Sardi²,

Gullo³

et al. 2013

Braz. J. Microbiol.

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Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.

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“…These proteolytic enzymes are able to hydrolyse keratins which are main protein constituents of hair, nails and skin (Akcaglar et al, 2011). Dermatophytes were colonizing on the host, and an ability to cause an infection leads to enzymatic degradation of keratin (Erbagci et al, 2004;Simpanya, 2000;Abdel-Rahman, 2001;Macêdo et al, 2005;Baeza et al, 2007). Dermatophytes are cosmopolitan, and it also causes infection in several animal species by creating generally dry, smoothed and usually non-pruritic lesions, distributed on the skin (Pereira and Meireles, 2001).…”

Section: Introductionmentioning

confidence: 99%

Antidermatophytic, the anticancer and antioxidant activity of Cassia alata ethanolic extract and its phytochemical analysis

Sujatha¹,

Rajeshkumar

Thangavelu

2019

ijrps

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Cassia alata is used traditionally to cure various diseases like ulcers, stomach pain and fever. The potential of antidermatophytic, free radical scavenging and cytotoxic activity of ethanol leaves extracts of C. alata was studied. The preliminary phytochemical screening assay elucidates that presence of carbohydrates, tannin, phenol, saponin, flavonoid, steroid, terpenoids, glycosides, and alkaloids. Further phytochemical extraction was done by GC-MS, HPLC and FTIR. GC-MS analysis confirms that the presence of two major compounds namely Hexadecanoic acid and Oleic acid with four minor compounds. HPLC techniques revealed that the presence of two major compounds observed in two different retention time. FTIR spectrum revealed that the presence of carboxylic groups, alkanes, aldehydes and aliphatic amines in the ethanol extract of C. alata leaves. Cytotoxic effect of ethanol extract was assayed at different concentrations like 10, 25, 50 and 100 μg/ml against human epithelial carcinoma (A431). At100 μg/ml of ethanol concentration, 93.26±5.44 (%) and 82.45±2.44 (%) percentage of cancer cells were inhibited by ethanol extract and standard drug, respectively. Microscopic images of cancer cells treated with ethanol extract confirm the morphological changes and shrinkages of cells leads to cell death. These results were suggesting that Cassia alata exhibit high potential antioxidant, antidermatophytic and cytotoxic activity and also it could serve as alternative new resources for manufacturing new drugs against newly evaluating diseases.

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Pathogenic aspects of Epidermophyton floccosum langeron et milochevitch as possible aethiological agent of Tinea capits

Cited by 7 publications

References 10 publications

ANTIDERMATOPHYTIC ACTIVITY OF GREEN SYNTHESISED ZINC OXIDE NANOPARTICLES USING Cassia alata LEAVES

ANTIDERMATOPHYTIC ACTIVITY OF GREEN SYNTHESISED ZINC OXIDE NANOPARTICLES USING Cassia alata LEAVES

Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products

Antidermatophytic, the anticancer and antioxidant activity of Cassia alata ethanolic extract and its phytochemical analysis

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