Aim: The aim of this study is to compare to microleakage levels of two silane based adhesive systems and one silane free adhesive system. Material and Method: Thirty standardized freshly extracted sound premolar teeth were used in study. Teeth were randomly and divided into three groups of 10 teeth each, according to the adhesive systems (n=20). Class V cavities were prepared (mesio-distal 4 mm, and occluso-gingival 3 mm, and 2 mm depth). After the adhesive systems were applied (Clearfil Universal Bond-silane based, Single Bond Universal-silane based and Adper Single Bond 2-silane free) composite resins (Filtek Z 250) were built up to the cavities. The specimens were aged with 5,000 thermocycles and immersed in 0.5% basic fuchsine solution during 24 hours. Then the samples were sectioned longitudinally in bucco-lingual and mesiodistal directions. The slices were observed under a stereomicroscope (X40 magnification). The scores were statistically analyzed using the Kruskal-Wallis and the Mann Whitney U tests. Results: Significant differences were found in microleakage values among the adhesive systems (p<0.05). The lowest microleakage value was recorded in the Single Bond universal (p<0.05). There were no significant differences in microleakage values among the Clearfil Universal Bond Adper Single Bond 2 (p>0.05). Statistical analysis revealed significant differences between the occlusal and gingival in all restorations (p<0.05). Conclusion: For all groups, microleakage values were higher at gingival margins than at occlusal margins. None of the materials tested in this study completely eliminated microleakage at both the enamel and gingival margin.