Effects of ligature-induced periodontitis in pregnant Wistar rats

Galvão, Mariane Ponzio de Azevedo; Rösing, Cassiano Kuchenbecker; Ferreira, Maria Beatriz Cardoso

doi:10.1590/s1517-74912003000100010

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…The results of this study are from a commonly used experimental rat model for periodontitis [40–44]. The impetus for choosing the ligature model is that it promotes scenarios similar to food impaction between teeth in humans.…”

Section: Discussionmentioning

confidence: 99%

The Adaptive Nature of the Bone-Periodontal Ligament-Cementum Complex in a Ligature-Induced Periodontitis Rat Model

Lee

Lin

Fong

et al. 2013

BioMed Research International

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The novel aspect of this study involves illustrating significant adaptation of a functionally loaded bone-PDL-cementum complex in a ligature-induced periodontitis rat model. Following 4, 8, and 15 days of ligation, proinflammatory cytokines (TNF-α and RANKL), a mineral resorption indicator (TRAP), and a cell migration and adhesion molecule for tissue regeneration (fibronectin) within the complex were localized and correlated with changes in PDL-space (functional space). At 4 days of ligation, the functional space of the distal complex was widened compared to controls and was positively correlated with an increased expression of TNF-α. At 8 and 15 days, the number of RANKL(+) cells decreased near the mesial alveolar bone crest (ABC) but increased at the distal ABC. TRAP(+) cells on both sides of the complex significantly increased at 8 days. A gradual change in fibronectin expression from the distal PDL-secondary cementum interfaces through precementum layers was observed when compared to increased and abrupt changes at the mesial PDL-cementum and PDL-bone interfaces in ligated and control groups. Based on our results, we hypothesize that compromised strain fields can be created in a diseased periodontium, which in response to prolonged function can significantly alter the original bone and apical cementum formations.

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Section: Discussionmentioning

confidence: 99%

The Adaptive Nature of the Bone-Periodontal Ligament-Cementum Complex in a Ligature-Induced Periodontitis Rat Model

Lee

Lin

Fong

et al. 2013

BioMed Research International

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“…[7][8][9][10] Animal models have also been used to study this association, however, without showing any clear tendency. 11 Despite the conflicting results, health practitioners need to be aware of the possibility of periodontal disease having an impact of negative outcomes on pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight

et al. 2011

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There is little information about the knowledge and attitudes of physicians regarding oral care. This study aimed to assess the knowledge and attitudes of obstetricians about the relationship between periodontal disease and preterm/low birth weight. A questionnaire was emailed to members of the Brazilian Federation of Gynecology and Obstetrics (FEBRASGO). The questionnaire elicited both personal information and knowledge and attitudes regarding the relationship between periodontal diseases and preterm labor. A total of 875 obstetricians responded to the questionnaire. The majority of respondents were female (54.1%), resided in the Southeast (45.6%), worked in both the public and private sectors (61.4%), and had over 15 years of experience in obstetrics (48.9%). A large proportion of obstetricians (93.4%) stated that bacteria were associated with periodontal disease, and 94% reported that periodontitis was a condition more severe than gingivitis. In total, over 80% of participating obstetricians reported smoking, preeclampsia, bacterial vaginosis and periodontal disease as risk factors or possible risk factors for preterm birth or low birth weight. A correlation between the experience of the obstetricians and referral of their patients for dental examinations (p < 0.001) was observed. Also, obstetricians who had had their own dental visits more recently were more likely to recommend the same for their patients (p < 0.001). It is concluded that, although obstetricians were aware of the association between gingival inflammation and adverse obstetric outcomes, the attitudes of these professionals were not in agreement with their apparent knowledge regarding periodontal diseases and their possible repercussions.

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“…However, some studies have shown no correlation between PLBW and maternal periodontal disease 7,8 . Published reports show that periodontitis during pregnancy increases bacteria and inflammatory mediators, which can enter the bloodstream and cause preterm membrane rupture and birth, increasing the potential for low birth weight 9 . Other experimental studies in rats show that ligature‐induced periodontitis promotes an increase in plasma levels of tumor necrosis factor‐α (TNF‐α) 10,11 .…”

mentioning

confidence: 99%

“…7,8 Published reports show that periodontitis during pregnancy increases bacteria and inflammatory mediators, which can enter the bloodstream and cause preterm membrane rupture and birth, increasing the potential for low birth weight. 9 Other experimental studies in rats show that ligature-induced periodontitis promotes an increase in plasma levels of tumor necrosis factor-a (TNF-a). 10,11 Sert et al 12 also reported increased levels of TNF-a and interleukin-6 (IL-6) in human mothers with periodontitis.…”

mentioning

confidence: 99%

Maternal Periodontal Disease in Rats Decreases Insulin Sensitivity and Insulin Signaling in Adult Offspring

Shirakashi

Leal

Colombo

et al. 2013

Journal of Periodontology

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Background: Periodontal disease during pregnancy has been recognized as one of the causes of preterm and low‐birth‐weight (PLBW) babies. Several studies have demonstrated that PLBW babies are prone to developing insulin resistance as adults. Although there is controversy over the association between periodontal disease and PLBW, the phenomenon known as programming can translate any stimulus or aggression experienced during intrauterine growth into physiologic and metabolic alterations in adulthood. The purpose of the present study is to investigate whether the offspring of rats with periodontal disease develop insulin resistance in adulthood. Methods: Ten female Wistar rats were divided into periodontal disease (PED) and control (CN) groups. All rats were mated at 7 days after induction of periodontal disease. Male offspring were divided into two groups: 1) periodontal disease offspring (PEDO; n = 24); and 2) control offspring (CNO; n = 24). Offspring body weight was measured from birth until 75 days. When the offspring reached 75 days old, the following parameters were measured: 1) plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and tumor necrosis factor‐α (TNF‐α); 2) insulin sensitivity (IS); and 3) insulin signal transduction (IST) in insulin‐sensitive tissues. Results: Low birth weight was not detected in the PEDO group. However, plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and TNF‐α were increased and IS and IST were reduced (P <0.05) in the PEDO group compared with the CNO group. Conclusion: Maternal periodontal disease may induce insulin resistance and reduce IST in adult offspring, but such alterations are not attributable to low birth weight.

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Effects of ligature-induced periodontitis in pregnant Wistar rats

Cited by 10 publications

References 21 publications

The Adaptive Nature of the Bone-Periodontal Ligament-Cementum Complex in a Ligature-Induced Periodontitis Rat Model

The Adaptive Nature of the Bone-Periodontal Ligament-Cementum Complex in a Ligature-Induced Periodontitis Rat Model

Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight

Maternal Periodontal Disease in Rats Decreases Insulin Sensitivity and Insulin Signaling in Adult Offspring

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