Caracterização de nanopartículas poliméricas preenchidas com óleo essencial de Piper nigrum por microscopia de força atômica

Costa, Ítalo Carvalho da; Azevedo, Sidney Gomes; Sanches, Edgar Aparecido; Filho, Henrique Duarte da Fonseca

doi:10.1590/s1517-707620210002.1281

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…Considering the loaded particles, Ra = (15 ± 1) and Rq = (20 ± 2) were obtained. These results revealed the influence of the essential oil on the surface roughness of particles after the encapsulation process [ 67 ]. Our results suggested that the loaded particles presented better conditions for application as a releasing product, due to its higher roughness and microtexture, favoring an efficient adhesion on another surface [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives

et al. 2022

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Considerable efforts have been spent on environmentally friendly particles for the encapsulation of essential oils. Polymeric particles were developed to encapsulate the essential oil from Piper nigrum based on gelatin and poly–ε–caprolactone (PCL) carriers. Gas Chromatography ((Flame Ionization Detection (GC/FID) and Mass Spectrometry (GC/MS)), Atomic Force Microscopy (AFM), Nanoparticle Tracking Analysis (NTA), Confocal Laser Scanning Microscopy (CLSM), Attenuated Total Reflectance–Fourier-transform Infrared Spectroscopy (ATR–FTIR), and Ultraviolet–Visible (UV–VIS) spectroscopy were used for the full colloidal system characterization. The essential oil was mainly composed of β-caryophyllene (~35%). The stability of the encapsulated systems was evaluated by Encapsulation Efficiency (EE%), electrical conductivity, turbidity, pH, and organoleptic properties (color and odor) after adding different preservatives. The mixture of phenoxyethanol/isotialzoni-3-one (PNE system) resulted in enhanced stability of approximately 120 and 210 days under constant handling and shelf-life tests, respectively. The developed polymeric system presented a similar controlled release in acidic, neutral, or basic pH, and the release curves suggested a pulsatile release mechanism due to a complexation of essential oil in the PCL matrix. Our results showed that the developed system has potential as an alternative stable product and as a controlling agent, due to the pronounced bioactivity of the encapsulated essential oil.

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Section: Resultsmentioning

confidence: 99%

Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives

et al. 2022

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“…P. nigrum essential oil was obtained through powdered seeds on a Clevenger‐type apparatus (Costa et al, 2021; da Costa et al, 2021). Colloidal systems were synthesized as follows: solution I was prepared by heating gelatin at 50°C in distilled water under constant magnetic stirring.…”

Section: Methodsmentioning

confidence: 99%

“…P. nigrum essential oil was obtained through powdered seeds on a Clevenger-type apparatus (Costa et al, 2021;da Costa et al, 2021).…”

Section: Nanoparticles Development and Essential Oil Encapsulationmentioning

confidence: 99%

“…As a result, novel systems can be prepared with enhanced water dispersibility, specific controlled release mechanisms and surface functionalization allowing their action on targeting ligands. Moreover, some reports have also pointed to the evaluation of spatial patterns of surfaces for biotechnological applications (da Costa et al, 2021;de Oliveira et al, 2017de Oliveira et al, , 2020Matos et al, 2018;Matos, Ramos, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Nanoscale surface dynamics of spatial patterns of polymeric bilayered particles loaded with essential oil

Matos

Costa

Yasumura

et al. 2022

Microscopy Res & Technique

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Gelatin/PCL bilayered particles loaded with Piper nigrum essential oil was synthesized aiming to access their morphological and surface dynamic patterns. Atomic force microscopy (AFM) was applied to investigate the 3D morphology and multifractal aspects of the particles surface. The AFM maps revealed spherical surfaces and well dispersed particles, besides a rougher surface on the loaded system. Minkowski functionals showed that shape of the rough peaks was similar in the unloaded and loaded systems; however, the presence of deep valleys on the loaded particles revealed their rougher pattern. Multifractal analysis revealed that unloaded and loaded particles presented multifractal behavior with different surface dynamics. The loaded surface presented a greater width of the multifractal spectrum and smaller difference of fractal dimensions, confirming their more vertically growing. These results can be useful in the development of novel polymeric‐based particles loaded with essential oil. Their unique surface dynamics can provide enhanced physical properties and performance in emerging biotechnological applications.

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“…As nanopartículas poliméricas são amplamente utilizadas na indústria farmacêutica para o encapsulamento de fármacos. Essas nanopartículas apresentam propriedade de modificar a sua superfície quimicamente, sendo divididas de acordo com sua organização e constituintes, que podem ser apresentadas em nanocápsulas e nanoesferas (Costa et al, 2021;Luna-Herrera et al, 2021).…”

Section: Nanopartículas Poliméricasunclassified

A nanotecnologia aplicada ao desenvolvimento de fármacos: revisão integrativa da literatura

Bezerra¹,

Bandeira²,

Lima³

et al. 2022

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A nanotecnologia é uma área da ciência responsável pelos estudos sobre sistemas estruturados em escala nanométrica. No campo farmacêutico, os nanocarreadores têm sido investigados como veículo de fármacos na síntese de medicamentos inovadores para solucionar dificuldades em relação a biodisponibilidade, estabilidade e toxicidade. As formulações farmacêuticas nanoestruturadas são capazes de controlar a liberação das moléculas e ainda direciona essas moléculas para seu local específicos de ação e, assim maximizar os efeitos benéficos da terapia, como também auxilia na redução dos efeitos adversos. Vários estudos vêm evidenciando excelentes resultados na eficácia terapêutica de nanocarreadores empregados na elaboração de novos fármacos. Ademais, estes nanofarmacos disponibilizam inúmeras vantagens quando comparado com as formas farmacêuticas convencionais. O presente trabalho tem como objetivo, realizar uma revisão integrativa da literatura sobre a empregabilidade da nanotecnologia no desenvolvimento de novos fármacos, discutindo sobre os principais nanocarreadores que podem ser utilizados para a obtenção de fármacos, como: lipossomas, nanopartículas poliméricas, nanopartículas lipídicas, dendrímeros e ciclodextrinas. Foram utilizados 31 artigos que passaram pelos critérios de inclusão, que exigiam artigos acadêmicos com o idioma em português, inglês, espanhol e chinês, publicados nos últimos cinco anos retroativos. Diante dos estudos realizados pelos autores, conclui-se que a nanotecnologia quando aplicada na produção de fármaco é bastante eficiente pois possibilita uma melhorar significativa nas suas propriedades farmacocinéticas resultando um tratamento seguro e efetivo ao paciente.

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Caracterização de nanopartículas poliméricas preenchidas com óleo essencial de Piper nigrum por microscopia de força atômica

Cited by 4 publications

References 29 publications

Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives

Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives

Nanoscale surface dynamics of spatial patterns of polymeric bilayered particles loaded with essential oil

A nanotecnologia aplicada ao desenvolvimento de fármacos: revisão integrativa da literatura

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