Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

Savicki, Cristiane; Camargo, Nelson Heriberto Almeida; Gemelli, Enori; Copatti, Cleomar; Camargo, Nicolas Almeida; Silva, Daiara Floriano

doi:10.1590/s1517-707620190001.0652

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…In the pharmaceutical field, polymers play a significant role in the development of medicines and they are gaining attention because they can achieve a delivery drug over a longer period [7]. For this, they are employed in various types of formulations such as microparticles, nanoparticles, microspheres, and others [8][9][10]. When a polymeric system is introduced into the body, the release of the drug occurs by a combination of its diffusion and polymer degradation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

et al. 2021

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Natural polymers have attracted much attention in recent years for the study of new drug delivery systems. These materials are used as polymer matrices to protect the active drug from degradation in the biological environment and to improve the release kinetics of the drug. The poly(3-hydroxybutyrate) (PHB) is a natural biocompatible polymer, widely used in combination with other polymers to improve their physicochemical properties. Thus, this work aimed to develop and characterize films of PHB and blends containing polypropylene glycol (PPG) with different concentrations of simvastatin (Simv.). The films were prepared by casting, dissolving PHB or a blend of PHB / PPG (90:10) and (5% or 25 %) Simv. in chloroform (2% w/v). The solutions were stirred for 3 h and then transferred to an appropriate glass mold for solvent evaporation for 48 h at room temperature. The obtained films were characterized by Fourier Transform Infrared (FTIR) spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), optical microscopy, in vitro degradation study, and in vivo biocompatibility test. The results showed that PHB and blends of PHB / PPG are able to form a homogeneous film with the drug inside. A great amount of drug lead to the instability of polymeric matrixes and resulted in a facilitated film degradation. On the other hand, devices with 5% of Simv. were more stable, which suggests the application of these films for biomedical devices. In vivo studies revealed that the films can interact with the animals' organism, and do not undergo rejection. Hence, these films hold an innovative alternative in tissue engineering to promotes drug release by diffusion and erosion of the polymeric material.

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Section: Introductionmentioning

confidence: 99%

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

et al. 2021

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“…HA particles show characteristic infrared bands at 562 cm −1 referred to as deformation vibration (PO 4 ) and 632 cm −1 (bonded OH). Bands of 959, 1024, and 1088 cm −1 are attributed to stretching vibrations of phosphate groups 48–50 . PCL/GE/EDC/HA scaffold spectrum has shown all important bands from PCL, GE, and HA.…”

Section: Resultsmentioning

confidence: 97%

“…Bands of 959, 1024, and 1088 cm À1 are attributed to stretching vibrations of phosphate groups. [48][49][50] PCL/GE/EDC/HA scaffold spectrum has shown all important bands from PCL, GE, and HA. Sattary et al 40 also found similar results in their study about the effect of the collector on PCL/GE/nano-HA electrospun scaffold properties.…”

Section: Sem Of Scaffolds Composed Of Random Nanofibers Is Shown Inmentioning

confidence: 99%

Effect of crosslinking, hydroxyapatite addition, and fiber alignment to stimulate human mesenchymal stem cells osteoinduction in polycaprolactone‐based electrospun scaffolds

Soares

2022

Polymers for Advanced Techs

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Electrospinning is a versatile technique for producing composite scaffolds with nanostructure properties similar to the natural extracellular matrix. Biomaterials possessing mechanical, structural, and biological properties required for bone tissue engineering are a big challenge. However, the effect of fiber alignment, their mechanical properties, and chemical modifications on fibers are usually investigated individually. In this study, PCL/GE/HA scaffolds were electrospun in a static and drum rotatory collector to investigate the effects of alignment on the physicochemical properties of composite scaffolds. Furthermore, to achieve a stable composite with natural polymer gelatin (GE), a water‐soluble, zero‐length crosslinker (N‐[3‐dimethylaminopropyl]‐N′‐ethylcarbodiimide hydrochloride, EDC) was used to crosslink GE. Our results have outlined that the incorporation of GE, as well as crosslinking process, produced a hydrophilic biomaterial, improving wettability compared to pure polycaprolactone (PCL). In addition, the alignment reinforced the material, increasing mechanical strength. Biological tests showed that GE addition and the alignment allowed a better osteoinduction than pure random PCL.

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“…42 The dip coating nanocomposite membranes exhibited more intense transmittance, indicating that the C20A nanoclay was more apparent and concentrated on the membrane surface. 105 Although using the same dispersed phase, the methods (EIPS/NIPS and dip coating) produced different membranes due to the different dispersion of the C20A nanometric loading.…”

Section: Fourier-transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Two different routes to prepare porous biodegradable composite membranes containing nanoclay

Zanini,

Ferreira,

Barbosa

et al. 2023

J of Applied Polymer Sci

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The method employed for membrane preparation and nanoparticle incorporation in membrane systems can affect their properties. This work aims to compare the better strategy to obtain membranes from the preparation of PBAT [Poly(butylene adipate co‐terephthalate)] containing nanoclay Cloisite® 20A (C20A) (0, 0.5, and 1 wt.%) by combined Evaporation/Non‐solvent Induced Phase Separation (EIPS/NIPS) or dip coating methods. The SEM, TGA, contact angle measurements, FTIR, XRD, mechanical testing, and cost analysis characterized EIPS/NIPS to dip coating membranes. EIPS/NIPS membranes had smaller pores (0.3–0.5 μm), with a more homogeneous pore diameter distribution due to C20A nanoclay insertion. PBAT/0.5% C20AEIPS/NIPS was the more hydrophilic membrane (37°) with better mechanical properties proven by statistical analysis. The cost analysis showed that EIPS/NIPS membranes production cost per square meter (m2) was lower (US$ 73.4–73.8) than dip coating (US$ 89.0–99.2). The EIPS/NIPS method was the most economically and statistically advantageous, and its properties can favor future applications for PTEs removal in aqueous media.

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Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

Cited by 3 publications

References 25 publications

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

Effect of crosslinking, hydroxyapatite addition, and fiber alignment to stimulate human mesenchymal stem cells osteoinduction in polycaprolactone‐based electrospun scaffolds

Two different routes to prepare porous biodegradable composite membranes containing nanoclay

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