Exposição repetida à cafeína aumenta a atividade locomotora induzida pelo femproporex em ratos adolescentes e adultos

Paro, Ana Helena; Aizenstein, Moacyr Luiz; DeLucia, Roberto; Planeta, Cleópatra da Silva

doi:10.1590/s1516-93322008000300011

Cited by 1 publication

(2 citation statements)

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“…Caffeine is considered to be the most psychoactive substance used worldwide (PARO, AIZENSTEIN, DELUCIA et al, 2008). About 80% of the world population consumes caffeine through food and beverage, such as coffee, tea, chocolate, soft drink, and through some medications taken as antagonistic agents of relaxing effect of some drugs (CAMARGO and TOLEDO, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…After oral ingestion, it is quickly absorbed through GI tract and rapidly eliminated, with a half-life of 4-6 hours. It reaches its blood serum maximum level between 15 and 120 minutes after swallowing, spread out to all body tissues, and exhibits a strong pharmacological action on the CNS (SILVA, 2010; PARO, AIZENSTEIN, DELUCIA et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Effects of coffee (Coffea arabica) consumption on the femoral morphology and biomechanics in rats

et al. 2014

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Introduction: Coffee consumption has proved to be harmful to osseous tissue integrity, thus, diminishing bone resistance. Considering the great number of individuals consuming coffee daily, therefore, the present study aims to demonstrate the effects of coffee on the femoral morphology and biomechanics resistance in Wistar rats. Methods: Twenty male Wistar rats were chosen for the experiment, divided into two groups (n = 10), as to know, CT (control) group, to which was offered water diet ad libitum; and, CF (coffee) group, to which was offered coffee as liquid diet. After 60 days, the animals had their blood analyzed for serum calcium level, they were euthanized and the right femurs were collected for histological procedure and the left ones were isolated for bone measures and mechanical test. Results: CF group animals do not present malnutrition or dehydration. Femur dimensions, trabecular bone width and cortical width analyses shown to be lower for CF group. Material and structural properties of the femurs of CF group animals demonstrate that this group presents weaker bones than those of CT group. Conclusion: The findings in the present study allow us to confirm that coffee consumption interferes negatively on the material and structural bone properties, diminishes trabecular and cortical bone density, and hence making bones more fragile and likely to fractures. So, due to the great number of individuals consuming coffee daily, it is important to reduce this consume on order to prevent bone trauma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%