Análise de custo do tratamento medicamentoso da artrite reumatóide

Monteiro, Roberta Dyonisio Canaveira; Zanini, Antonio Carlos

doi:10.1590/s1516-93322008000100004

Cited by 11 publications

(5 citation statements)

References 10 publications

(14 reference statements)

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“…For the treatment of some pathologies, such as rheumatoid arthritis, some types of drugs such as disease-modifying drugs (DMARDs) are commonly used [82,83,84]. This group of drugs presents a series of chemically unrelated drugs, such as antimalarial drugs, methotrexate, leflunomide, IL-1 receptor antagonists, cytotoxic agents, and biological TNF-α blocking agents [83,85,86].…”

Section: Discussionmentioning

confidence: 99%

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction

et al. 2019

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: The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 μg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction.

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Section: Discussionmentioning

confidence: 99%

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction

et al. 2019

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“…However, the cost of these agents is high [29,30], which makes it difficult its use in Brazil, especially in small centers, as the studied one. We believe that the economic is one of the most relevant factor for the treatment in Brazil, since the health-related costs have reached unsustainable levels to the two most important paying medical services in the country (Unified Public Health System and Prived health plans) [31]. The public health question if the benefits of innovations drug outweighs its high prices [32].…”

Section: Discussionmentioning

confidence: 99%

Functional capacity in rheumatoid arthritis patients: comparison between Spanish and Brazilian sample

et al. 2009

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The main objective of this study is to compare Spanish and Brazilian self-reported health-related functional capacity in patients with rheumatoid arthritis (RA). 197 patients diagnosed with RA were studied in Spain (n = 127) and Brazil (n = 70). Pain (Visual analog scale) and functional capacity (Health Assessment Questionnaire/HAQ) were assessed. Patients were questioned about regular exercise practice. Comparisons between groups were performed with Chi-square tests and Student t test. Pearson's correlation coefficient and linear regression models were used to analyze the associations. Brazilian patients were younger (p = 0.013), had worse levels of pain (p = 0.001) and a trend to experience worse functional capacity (p = 0.057) than Spanish ones. Spanish RA patients had higher body mass index (BMI) (p = 0.019) and longer disease duration (p = 0.001). Also, a higher percentage of subjects with RA from the Spanish cohort had been elected to take early retirement when compared with Brazilian patients (p = 0.010). Spanish RA patients had received more drugs than Brazilians (oral corticosteroids p = 0.010, Leflunomide p = 0.023, Methotrexate p = 0.072, non-steroidal anti-inflammatory drugs p = 0.064, biologic therapies p = 0.001). The functional capacity (HAQ) was correlated with age (p = 0.001), disease duration (p = 0.001), age at diagnosis (p = 0.001), pain (p = 0.001) and BMI (p = 0.001) in Spanish patients. In Brazilian, these correlations were only found with disease duration (p = 0.004) and pain (p = 0.001). In conclusion, our data suggest a better management of RA in Spanish when compared with Brazilians. Even with less pain and functional capacity, they receive more drug treatment and a higher percentage of them are retired early.

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“…Portanto, é essencial que o diagnóstico seja realizado o mais cedo possível, a fim de gerenciar e monitorar os recursos de forma adequada (MONTEIRO & ZANINI, 2008).…”

Section: Introductionunclassified

Diagnostic challenges of rheumatological conditions in the Family Health Strategy

Cerqueira Silva,

De Sousa,

Ramos

et al. 2023

CLIUM

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Objective: To characterize the main rheumatic complaints in an outpatient clinic of a Basic Health Unit. Methods: This is a quantitative, retrospective, descriptive, and documentary study conducted at a Basic Health Unit in Teresina – PI. Results: A total of 365 electronic medical records of patients seen in the general clinic were analyzed, excluding pregnant women and those below 50 years of age. Among the complaints recorded in 15% of the records, pain was the most prevalent (64.04%), followed by pain and edema (14.06%), and pain radiating to the limbs (12.5%). The epidemiological aspect showed that 80.70% of the complaints came from women, and were more common among patients aged 50 to 60 years (52.63%). The lumbar spine was the most affected site (33.34%). Conclusion: These results reinforce the frequency of rheumatic complaints in primary care, with an emphasis on pain in the lumbar spine in female patients during the early stages of aging.

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Análise de custo do tratamento medicamentoso da artrite reumatóide

Cited by 11 publications

References 10 publications

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction

Functional capacity in rheumatoid arthritis patients: comparison between Spanish and Brazilian sample

Diagnostic challenges of rheumatological conditions in the Family Health Strategy

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