Comparative study on two rapid and sensitive methods for quantitative determination of tenoxicam in tablets

Singh, Anil Kumar; García, Pedro López; Gomes, Fábio Pereira; Kedor-Hackmann, Érika Rosa Maria; Santoro, María Inés Rocha Miritello

doi:10.1590/s1516-93322007000400015

Cited by 4 publications

(5 citation statements)

References 26 publications

(15 reference statements)

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“…Under the conditions described before, MX showed a characteristic peak at 3.08 min, and the characteristic peak of TX appeared at 3.33 min. Compared with the data reported in the literature [20,21], the retention times of MX and TX have been improved.…”

Section: Resultsmentioning

confidence: 71%

Validation of High Performance Liquid Chromatography Methods for Determination of Meloxicam and Tenoxicam from Transdermal Therapeutic Systems

Antonoaea

Cârje

Ciurba

et al. 2017

Acta Medica Marisiensis

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Objective: The aim of this study was to develop and validate two HPLC methods for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems. Methods: Based on 1.0% hydroxypropyl methylcellulose 15000, transdermal patches containing meloxicam or tenoxicam were prepared by solvent evaporation technique. Analytical performances of the HPLC methods for the quantification of meloxicam and tenoxicam from such systems were assessed in terms of specificity, linearity, detection limit, quantification limit, recovery and precision. Results and discussion: The linearity of the method was assessed through a calibration curve in the 1.0 -75.0 μg•mL-¹ concentration range, with a regression coefficient higher than 0.999. The detection limit and the quantification limit were found to be 0.46 μg•mL-¹ and 1.39 μg•mL-¹, for meloxicam; and 0.88 μg•mL-¹, respectively 2.64 μg•mL-¹ for tenoxicam. According to the European Pharmacopeia 5.0 the mean recovery was found to be between 75% and 125%. As performance criteria for precision was used the RSD% which were lower than 2.0% for both methods. Conclusions: The proposed liquid chromatography methods provide selective, linear and precise results for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems. The presence of a single peak in the chromatograms of the analyzed transdermal patches with meloxicam or tenoxicam, certify the successful determination of the active pharmaceutical ingredient in the prepared patches.

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Section: Resultsmentioning

confidence: 71%

Validation of High Performance Liquid Chromatography Methods for Determination of Meloxicam and Tenoxicam from Transdermal Therapeutic Systems

Antonoaea

Cârje

Ciurba

et al. 2017

Acta Medica Marisiensis

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“…Using the Student's t -test and the variance ratio F -test, 65 the results obtained were compared to those of reported methods. 22,34,41 According to the calculated t and F values, 65 there is no considerable difference between the methods in terms of accuracy and precision, respectively as shown in Table 5.…”

Section: Resultsmentioning

confidence: 87%

“…The accuracy of the proposed method was demonstrated by comparing the results of the proposed method in raw materials and pharmaceuticals to the results of the comparison methods. 22,34,41 Data in Table 3 illustrate no signicant differences between the performance of the two methods concerning the accuracy and precision. This was conrmed by statistical analysis of the data using Student's t-test and variance ratio F-test, respectively.…”

Section: Validation Of the Methodsmentioning

confidence: 98%

“…1b), is a thiophene derivative, chemically named 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e] [1,2]thiazine-3-carboxamide1,1-dioxide. Various methods for analysis of TNX have been reported, including spectrophotometry, 24,25,33,34 spectrouorimetry, 35 HPLC 34,36,37 and electrochemical methods. 38,39 The structure of lornoxicam (LRX, Fig.…”

Section: Introductionmentioning

confidence: 99%

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Thiosemicarbazide functionalized carbon quantum dots as a fluorescent probe for the determination of some oxicams: application to dosage forms and biological fluids

et al. 2022

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“…Spectrophotometric, , derivative spectrophotometric, infrared spectrophotometric, colorimetric, and spectrofluorometric methods have been reported to determine TNX in pharmaceutical dosage forms. Some high-performance liquid chromatography (HPLC) approaches were utilized to determine TNX in pure and dosage forms. − In the transdermal therapeutic system, TNX and meloxicam were also determined using an HPLC approach . A HPLC approach has also been used to measure potential genotoxic impurity, 5-amino-2-chloropyrine in TNX .…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly High-Performance Thin-Layer Chromatography Method for the Determination of Tenoxicam in Commercial Formulations

Shakeel,

Alam,

Haq

et al. 2023

ACS Omega

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There is a dearth of information in the literature regarding environmentally benign high-performance thin-layer chromatography (HPTLC) methods to determine tenoxicam (TNX). Therefore, designing and validating an HPTLC method to detect TNX in commercial tablets and capsules was the goal of this investigation. The green mobile phase utilized was the combination of ethanol/water/ammonia solution (50:45:5 v/v/v). The TNX was quantified at a wavelength of 375 nm. The proposed method's greenness profile was established using the Analytical GREEnness (AGREE) approach. The proposed methodology for determining TNX was linear in the range of 25−1400 ng/band. The proposed methodology for measuring TNX was accurate (% recoveries = 98.24−101.48), precise (% RSD = 0.87−1.02), robust (% RSD = 0.87−0.94), sensitive (LOD = 0.98 ng/band and LOQ = 2.94 ng/band), and environmentally friendly. The AGREE scale for the present methodology was derived to be 0.75, indicating an outstanding greenness profile. TNX was found to be highly stable under acidic, base, and thermal stress conditions. However, it completely decomposed under oxidative stress conditions. Commercial tablets and capsules were found to have 98.46 and 101.24% TNX, respectively. This finding supports the validity of the current methodology for measuring TNX in commercial formulations. The outcomes of this work showed that the proposed eco-friendly HPTLC methodology can be used for the routine analysis of TNX in commercial formulations.

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Comparative study on two rapid and sensitive methods for quantitative determination of tenoxicam in tablets

Abstract: Tenoxicam, a piroxicam analogue, is an NSAID (Non-Steroid Antinflamatory Drug). It is used in the symptomatic

Cited by 4 publications

References 26 publications

Validation of High Performance Liquid Chromatography Methods for Determination of Meloxicam and Tenoxicam from Transdermal Therapeutic Systems

Validation of High Performance Liquid Chromatography Methods for Determination of Meloxicam and Tenoxicam from Transdermal Therapeutic Systems

Thiosemicarbazide functionalized carbon quantum dots as a fluorescent probe for the determination of some oxicams: application to dosage forms and biological fluids

Eco-Friendly High-Performance Thin-Layer Chromatography Method for the Determination of Tenoxicam in Commercial Formulations

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