Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Ojoe, Evelyn; Miyauchi, Edna Mitie; Kaneko, Telma Mary; Velasco, Maria Valéria Rolbes; Consiglieri, Vladi Olga

doi:10.1590/s1516-93322007000400010

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…The n value for formulations F2, F3 and F4 were 0.976, 0.987 and 0.988 respectively and those for F4, F5 and F6 were 0.977, 0.984 and 0.983 respectively Korsmeyer-Peppas kinetic model showed the best fitting for the formulations [17].…”

Section: Release Kineticsmentioning

confidence: 91%

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Formulation and Evaluation of Tramadol HCl Matrix Tablets Using Carbopol 974P and 934 as Rate-Controlling Agents

Rehman¹,

Khan²,

Shah³

et al. 2013

Trop. J. Pharm Res

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Section: Release Kineticsmentioning

confidence: 91%

“…Its value ranges from 50 -100. Values < 50 show dissimilarity while values > 50 indicate similarity in in vitro release drug profile [16,17]. f 2 was determined as in Eq 6.…”

Section: Determination Of Similarity Factor (F 2 )mentioning

confidence: 99%

Formulation and Evaluation of Tramadol HCl Matrix Tablets Using Carbopol 974P and 934 as Rate-Controlling Agents

Rehman¹,

Khan²,

Shah³

et al. 2013

Trop. J. Pharm Res

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“…Após adição de HPMC na matriz, os demais lotes A Goma guar constitui um material promissor frente à liberação controlada de fármacos em sistemas matriciais [19][20][21] . No entanto, este polissacarídeo utilizado sozinho não foi capaz de controlar a taxa de teofilina liberada, por isso foi associado a um polímero hidrofílico (HPMC), amplamente utilizado em comprimidos de liberação controlada [22][23][24] . Observou-se que a associação de 25% de HPMC à matriz polimérica é suficiente para que ocorra um maior controle da liberação do fármaco.…”

Section: Grau De Intumescimento (Gi) E Perfil De Liberação Do Fármacounclassified

Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina

et al. 2015

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ResumoO objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina. Palavras-chave: Goma Guar, teofilina, comprimidos, liberação controlada. AbstractGuar gum (GG) has been widely used in drug delivery systems due to its low cost and nontoxicity. Theophylline controlled release tablets were prepared by directly compressed method using two polymers such as HPMC K 100M (hydrophilic polymer) and Guar Gum (natural polymer), isolated or in mixture (GG:HPMC 3:1 and GG:HPMC 1:3). The formulated tablets were evaluated for: weight variation, diameter, height, hardness and friability. All the parameters were within the acceptable limits. The swelling test was performed in distilled water for 4 hours, it was determined by the difference in weight of the dry and swollen tablet. The dissolution test was performed in distilled water (900 mL, 37 ± 0.5ºC, 50 rpm, apparatus II) for 8 hours. The results showed that guar gum alone could not control the theophylline release effectively for 8 hours. Matrix tablet prepared from GG: HPMC (3:1) is a better formulation for the sustained released matrix tablets of theophylline.

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“…The drug is well absorbed from GIT with 90-100% bioavailability. Its therapeutic concentration range is narrow from 10 to 20μg/ml while toxicity usually appears at concentration above 20μg/ml (Ojoe et al, 2007). Since theophylline having narrow therapeutic index and short half life (8 hrs in adults).…”

Section: Introductionmentioning

confidence: 99%

Formulation development and evaluation of sustained release matrix tablets of Theophylline and Etophylline and study of polymers effect on dissolution rate

Khan¹,

R²,

Perumal³

2018

Asian J Pharm Pharmacol

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Objective: The present investigation an effort has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient fulfilment, by developing SR matrix tablets of Theophylline and Etophylline by using wet granulation technique incorporating different polymers combinations and fillers. Materials and methods: SR tablets of various combinations were prepared by using hydrophilic polymer: HPMC, sodium alginate and starch as fillers. The drug excipient mixtures were subjected to preformulation studies. The formulated tablets (F1-F10) were evaluated for different physicochemical properties and comply with the official standards. FTIR studies shown there was no interaction between drug and polymers. The optimized formulations (F3) were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern. Assay of the drug and formulation was carried out by using RP-HPLC method. The in vitro release studies exhibits the Results: release up to 82%, over a prolonged period of time which confirms the extended release profile of formulation (F3) after 6 hrs as compared to marketed formulation thus, drug in combination with HPMC were found to be effective in retarding the release of drugs. The SR matrix tablets of theophylline and etophylline shown better Conclusion: bioavailability, efficacy and potency compared with official standards.

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Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Abstract: In this study, the effect of ethylcellulose (EC)

Cited by 4 publications

References 19 publications

Formulation and Evaluation of Tramadol HCl Matrix Tablets Using Carbopol 974P and 934 as Rate-Controlling Agents

Formulation and Evaluation of Tramadol HCl Matrix Tablets Using Carbopol 974P and 934 as Rate-Controlling Agents

Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina

Formulation development and evaluation of sustained release matrix tablets of Theophylline and Etophylline and study of polymers effect on dissolution rate

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