Formas farmacêuticas sólidas orais de liberação prolongada: sistemas monolíticos e multiparticulados

Pezzini, Bianca Ramos; Silva, Marcos Antônio Segatto; Ferraz, Humberto Gomes

doi:10.1590/s1516-93322007000400002

Cited by 45 publications

(64 citation statements)

References 26 publications

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“…It confirms that the Brazil nut oil is capable of forming large ranges of translucent systems. Several works have reported translucent formulation with capric/caprylic acid triglycerides (Ribeiro et al, 2015;Cotrim et al, 2016) and Babassu oil , but none containing Brazil nut oil.…”

Section: Resultsmentioning

confidence: 99%

“…Levamisole (LMS) is a synthetic imidazothiazole derivative, and has been used as antirheumatic drug in 1970s and for colon cancer treatment with 5-fluorouracil in 1990s (Figure 1). Currently, it is mostly used as anthelmintic agent by paralyzing worm's muscles (Ribeiro et al,2015). Besides, some authors have considered LMS as a bio pharmaceutics III in drug classification, indicating that due to permeability issues its oral bioavailability can be diminished (Shaji and Jadhav 2010), which calls attention to the possibility of improvement when combined in other systems, as ME.…”

Section: * Corresponding Authormentioning

confidence: 99%

“…The HLB of the surfactant mixture (SP and TW) and the composition required to achieve an HLB corresponding to the oily phase were calculated (Ribeiro et al, 2015).…”

Section: Surfactant Mixing Ratiomentioning

confidence: 99%

“…The poor bioavailability is a common issue in drug development, which implies in more frequent drug administrations to reach the effect, and blood level fluctuations due to poor drug release pattern. Such issues lead to sub dosage or toxicity, among several other disadvantages implying to an inefficient pharmacologic therapy (Pezzini et al, 2007). An alternative to minimize such risks and improve drug therapy is by utilizing pharmaceutical systems that modify the drug kinetics, and increase the amount of active pharmaceutical ingredient (API)available in the organism, delivering at its site of action in a regulated speed (Hu et al, 2008;Hafner et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…ME have become a promising bioavailability enhancer. For that, immiscible liquids are stabilized by surfactants, reducing their surface tension, emulsifying, dispersing and solubilizing solutes, combining the active ingredient in one of the phases (Acharya and Hartley, 2012;Lawrence and Rees, 2012;Ribeiro et al, 2015). Its benefits include increased API solubility, minimized degradation processes such as thermal and photo degradation, gastric resistance, controlled release of active ingredient, reduction of therapeutic dosage and consequent side effects, improving the adherence to treatment which leads to a significant improvement of a known therapy (Kesarwani and Gupta, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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Brazil nut (Bertholletia excelsa H. B. K.) is one of the most valuable national Lecythidaceae from Brazil, collaborating with local economy. Besides being rich in nutrients, it has high content of unsaturated fatty acids, proteins and vitamins. On the other hand, levamisole (LMS) is a synthetic imidazothiazole derivative mostly used as agent in anthelmintic treatment; however it is reported to have issues in its oral bioavailability. Microemulsion (ME), immiscible liquids stabilized by surfactants, is a promising bioavailability enhancer nowadays by modifying the release of active ingredient at its site of action, reducing therapeutic dosage with consequent side effects, and increasing absorption of natural ingredients. So, the development of a stable ME containing Brazil nut oil to carry LMS can be a promising pharmaceutical form in this drug therapeutic efficiency behalf. For that, it was developed a stable oil-in-water ME which held pH, conductivity, and refractive index along the study, presenting satisfactory stability under long-term stress conditions. Its particle size is classified as nanostructure (33,35nm), and rheological parameters confirmed a Newtonian behavior, with constant viscosity. The Brazil nut oil ME can be an alternative as adjuvant in pharmaceutical forms and a promising upgrading tool to carry LMS, improving its therapy.

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Section: Resultsmentioning

confidence: 99%

Section: * Corresponding Authormentioning

confidence: 99%

“…The HLB of the surfactant mixture (SP and TW) and the composition required to achieve an HLB corresponding to the oily phase were calculated (Ribeiro et al, 2015).…”

Section: Surfactant Mixing Ratiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Silveira

Novack

Marcondes

et al. 2018

Macromolecular Symposia

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The graft copolymer PMMA‐g‐PEG meets characteristics of their origin polymers: PMMA resistance and transparency and appropriate structure, including good solubility in water and organic solvents, lack of toxicity, and easy processing of the PEG, with inserted between the pharmacologically active polymers and can act as drugs or may be used as carriers for other drugs. The PMMA‐G‐PEG copolymer and their derivatives are synthesized previously and subsequently, the copolymer derivatives passed through the process of emulsification and incorporation of the drug fluconazole. Emulsified and Incorporated derivatives copolymers are characterized by Fourier‐transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential thermal analysis (DTA), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) after the incorporation, in order to evaluate their effectiveness. The efficiency of incorporation is evaluated as well as the influence of polymer chain complexity in the incorporated fluconazole. Their toxicities are determined against Artemia salina Leach. The LD50 values have also been obtained for these copolymers.

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