Avaliação biofarmacotécnica in vitro de formas farmacêuticas sólidas contendo doxiciclina

Aguiar, Geysa; Faria, Luciane Gomes; Ferraz, Humberto Gomes; Serra, Cristina Helena dos Reis; Porta, Valentina

doi:10.1590/s1516-93322005000400007

Cited by 1 publication

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References 4 publications

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“…The tablets kinetics of release from SSBI, SSBIII and reference medicine, Rochagan TM , follows the method used for dissolution tests, being the times of collection 10, 30, 45, 60 and 120 minutes. The results were used to calculate the dissolution efficacy (DE) and later compared with the variance analysis (ANOVA) (Aguiar et al, 2005;Anderson et al, 1998;Khan, 1975;Khan, Rhodes, 1972).…”

Section: Kinetic Of In Vitro Releasementioning

confidence: 99%

Development and in vitro evaluation of tablets based on the antichagasic benznidazole

Sobrinho¹,

Lima²,

Perrelli³

et al. 2008

Rev. Bras. Cienc. Farm.

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This work aimed to verify the interferences caused by the use of excipients for immediate release tablets based on benznidazole obtained by direct compression and the accomplishment of a comparative study between the tablets developed and the reference medicine Rochagan TM , obtained by wet granulation. Seven smallscale batches (SSB) were developed and aspects such as compressibility, powder flow, mean weight, friability, disintegration, hardness, assay, content uniformity, kinetic of release in vitro (dissolution) and drug/excipients physical-chemical compatibility were evaluated. Based on the obtained results it can be verified that the analyzed powders presented adequated characteristics for the direct compression process, beyond the inexistent evidence of a physical-chemical interaction between the drug and the tested excipients. The tablets obtained from SSB I and III were chosen for the comparative study with the reference medicine, demonstrating similarity with the statistically treated obtained results, becoming an alternative option of a medicine product for the treatment of Chagas' disease with reduced cost and satisfactory quality.

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Section: Kinetic Of In Vitro Releasementioning

confidence: 99%