Lanreotide and octreotide complexed with technetium-99m: labeling, stability and biodistribution studies

Faintuch, Bluma Linkowski; Pereira, N.P. Sosa de; Faintuch, Salomão; Muramoto, Emiko; Silva, Constancia Pagano Gonçalves

doi:10.1590/s1516-93322004000100015

Cited by 4 publications

(3 citation statements)

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“…World Journal of Nuclear Medicine / Volume 18 / Issue 2 / April-June 2019 the somatostatin analog is labeled with Indium-111, this enforced some limitations such as limited availability, high cost, higher radiation burden to the patient, and the overall suboptimal image quality. [7] One and a half-decade back Decristoforo et al described the development of a Tc-99m-labeled somatostatin analog (Tyr3-octreotide [TOC] and hydrazinonicotinic acid [HYNIC]). [8] In their study, they found that Tc-99m-TOC had high tumor to background ratio and optimal imaging time, which was done as 1-day protocol as appose to the 2 days' protocols (4 and 24 h imaging) for In-111-OCT. With the advent of positron emission tomography/computed tomography (PET/CT), more positron emitting radiotracers were used to image the NETs, those include fluorine-18-fluoro-2-deoxy-D-glucose followed by 6-fluoro-(18F)-L-3,4-dihydroxyphenylalanine.…”

Section: Diagnostic Accuracy Of Technetium-99m-octreotide In Imaging ...mentioning

confidence: 99%

“…[6] However, because the somatostatin analog is labeled with Indium-111, this enforced some limitations such as limited availability, high cost, higher radiation burden to the patient, and the overall suboptimal image quality. [7] One and a half-decade back Decristoforo et al . described the development of a Tc-99m-labeled somatostatin analog (Tyr3-octreotide [TOC] and hydrazinonicotinic acid [HYNIC]).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

et al. 2019

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The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15–75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation. Twenty-three patients had true positive Tc-99m-OCT scan. In addition to the primary tumors, the octreotide scan revealed metastasis in the lung, liver, and retroperitoneal lymph nodes. The smallest lesion detected on octreotide scan was a 4-mm pulmonary nodule that was missed on lung window CT scan. The Tc-99m-OCT had 17 true negative, one false negative, and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative, and one false positive. The overall sensitivity, specificity, accuracy, positive, and negative predictive values of Tc-99m-OCT scan were 96%, 100%, 97%, 100%, and 94%, respectively. Whereas those of CT and MRI were 78%, 94%, 85%, 94%, and 77%, respectively. Our diagnostic accuracy of Tc-99m-OCT is high. We recommend that, in addition to the conventional radiological investigations, Tc-99m-OCT scan, or other somatostatin receptor imaging (SSR) is a mandate for better and accurate staging of patients with NETs.

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Section: Diagnostic Accuracy Of Technetium-99m-octreotide In Imaging ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

et al. 2019

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“…Its nuclear features of 6-hour half-life and gamma energy of 140 keV make it one of the best radionuclides as regards imaging qualities, with a half-time long enough to permit complete studies without an unnecessary dose of radiation. It is easily available by elution in isotonic saline from a 99 Mo/ 99m Tc generator (Marques et al, 2001;Faintuch et al, 2004). The direct method for radiolabeling reduced Mabs with 99m Tc and methylene diphosphonate (MDP) developed by Schwarz et al (1987) and Mather et al (1990) has been proved as a good procedure to obtain high labeling efficiency and a stable labeled Mab.…”

Section: Introductionmentioning

confidence: 99%

Tc-99m direct radiolabeling of monoclonal antibody ior egf/r3: quality control and image studies in mice

Dias

Marczewski

Moraes

et al. 2005

Braz. arch. biol. technol.

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Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.
Anticorpos monoclonais (AcM) tem sido usado para aplicações imunocintilográficas no diagnóstico clínico desde sua introdução na prática da medicina nuclear. O ior egf/r3 (Centis, Cuba) é um anticorpo monoclonal murino contra o receptor do fator do crescimento epidérmico (EGF-R) e tem sido usado extensivamente no radioimunodiagnóstico de tumores de origem epitelial. Marcado com 99mTc sua maior aplicação em Medicina Nuclear é: acompanhamento, detecção e avaliação de recorrências tumorais. O objetivo deste trabalho é descrever a preparação da formulação liofilizada (kit) para radiomarcação do AcM ior egf/r3 com 99mTc para aplicações imunocintilográficas. A eficiência da radiomarcação, efeito sobre a imunorreatividade, estudos de imagem e estabilidade da formulação são relatados. O estudo demonstrou que a formulação do kit pode ser marcada com 99mTc com alto rendimento e pode ser usado para visualizar in vivo tumores humanos de origem epitelial por estudos imunocintilográficos

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Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: in vitro characterization, ^99mTc-radiolabeling and in vivo biodistribution studies

Aboumanei

Mahmoud

Motaleb

2021

Drug Development and Industrial Pharmacy

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Lanreotide and octreotide complexed with technetium-99m: labeling, stability and biodistribution studies

Cited by 4 publications

References 11 publications

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Tc-99m direct radiolabeling of monoclonal antibody ior egf/r3: quality control and image studies in mice

Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: in vitro characterization, ^99mTc-radiolabeling and in vivo biodistribution studies

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Lanreotide and octreotide complexed with technetium-99m: labeling, stability and biodistribution studies

Cited by 4 publications

References 11 publications

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Tc-99m direct radiolabeling of monoclonal antibody ior egf/r3: quality control and image studies in mice

Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: in vitro characterization, 99mTc-radiolabeling and in vivo biodistribution studies

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Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: in vitro characterization, ^99mTc-radiolabeling and in vivo biodistribution studies