Efeito da concentração do amido de milho na liberação de paracetamol de comprimidos

Castro, André Luís da Silva; Vicente, Joice Alessandra; Mourão, Samanta Cardozo; Bueno, J.H.F; Evangelista, Raul Cesar; Gremião, Maria Palmira Daflon

doi:10.1590/s1516-93322003000300008

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…The importance of choosing the correct formulation components and optimizing their concentration is necessary since the speed and extent of the released drug can be substantially altered as a result of pharmaceutical adjuvants (Castro et al, 2003). Therefore, attention should be paid to the type, quantity and quality of adjuvants to be used in the formulation.…”

Section: Adjuvantmentioning

confidence: 99%

Pharmaceutical evaluation of compounded furosemide capsules and excipient performance

Barbosa

Rozário

Souza

et al. 2022

Braz. J. Pharm. Sci.

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Compounding pharmacies play an important role not only in compounding personalized formulations, but also preparing drugs at the same concentration and dosage as those from commercial manufacturers. The excipients used in compounding are generally standardized for many drugs, however they do not consider the intrinsic properties, such as the poor water solubility, of each substance. The excipient performance of commercially available compounded furosemide capsules in 7 compounding pharmacies from Manaus was evaluated and compared them to the performance of the reference medicinal product (Lasix ® tablets) and 2 batches of capsules made in-house (T2 and T4) with a standardized excipient. All batches were subjected to tests for weight variation, assay, uniformity of dosage units, disintegration and dissolution profile. Of the 7 different compound formulas acquired in the compounding pharmacies, only 2 passed all tests. Most formulas passed the tests for weight determination, disintegration time and assay, however batches from 2 establishments failed in regards to the uniformity of the content and 5 batches failed the dissolution test. The reference medicinal product was approved in all tests, as were the T2 capsules made in-house with drug-excipient ratio 1:2. These results confirm the importance of the excipient composition, especially for poorly soluble drugs.

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Section: Adjuvantmentioning

confidence: 99%