Avaliação da sensibilidade de cepas de Malassezia furfur a imidas cíclicas

BACKGROUND:Pityriasis versicolor (PV) is a cutaneous pigmentation disorder caused by a lipophilic yeast of the genus Malassezia sp. It is a superficial mycosis characterized by well-defined, slightly scaly skin lesions of variable color. In Brazil, the number of reported cases is small, and there are few epidemiological studies. OBJECTIVES:to assess incidence, characteristics of the lesions, effectiveness of the Zileri's Sign procedure, and the epidemiological profile of PV in the urban area of Buerarema - Bahia. METHODS:Biological samples were collected on pre-established days at Basic Health Care Units from July to September 2010. Sample collection was followed by laboratory diagnosis using Porto's Method. RESULTS:Of the 158 patients with suspected PV participating in the study, 105 (66.5%) were positive; 72 (68.6%) were female and 33 (31.4%) were male. Sex and location of lesions showed statistically significant differences (p<0.05). The region with the highest rate of cases of PV was found to be the center of the city, with 40.9% of diagnosed cases. The most affected age group was between 10 and 19 years. There was a significant association between the results produced through Zileri's Sign and Porto's Method in relation to positive and negative results (p<0.05). CONCLUSIONS: The results showed a higher prevalence of PV among individuals at puberty. The Zileri's Sign method proved to be counterproductive, because it showed low efficacy as a method for clinical diagnosis, yielding negative results for 36 (34.3%) patients who had been diagnosed with PV through laboratory examination.

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“…Such lesions may spread and coalesce to cover large areas, thus compromising trunk, shoulders, upper limbs, neck, face, and flexural folds. 5,18 …”

Section: Introductionmentioning

confidence: 99%

Pityriasis versicolor: clinical-epidemiological characterization of patients in the urban area of Buerarema-BA , Brazil

Santana

Azevedo

Filho

2013

An. Bras. Dermatol.

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“…Entre éstos, existen productos de origen natural que por su composición son mejor tolerados por el hospedero y muchas veces conllevan más de un benefi cio para los pacientes [9][10][11][12][13] . Entre los productos naturales con actividad antimicrobiana de uso tópico destacan el aceite derivado del árbol del té 28 , aceites esenciales y compuestos sulfhídricos de ajos 13 y de plantas silvestres como canela, sasafrás y bulbos [14][15][16][17][18] , así como el aceite de maravilla ozonizado [20][21][22][23]34,35 . Sin embargo, se requiere optimizar los productos naturales con el objetivo de avanzar hacia fármacos más activos, seguros y estables que permitan su proyección hacia el uso individual o combinado con moléculas tradicionales en el tratamiento de pacientes 9,11 .…”

Section: Discussionunclassified

“…Extractos alcohólicos, aceites esenciales y compuestos de naturaleza sulfhídrica aislados de los bulbos de ajos (Allium sativum), así como los aceites derivados de Eucalyptus globosus y otros extractos alcohólicos de plantas silvestres, imidas cíclicas y leguminosas, tienen un efecto antimicótico contra algunos géneros de levaduras, dermatofi tos u otros hongos fi lamentosos [12][13][14][15][16][17][18] . Otro compuesto con actividad antimicrobiana es el aceite de maravilla o girasol ozonizado, siendo el ozono la unidad alotrópica del oxígeno, constituido por moléculas triatómicas de este elemento, que sería el responsable de potenciar la actividad antimicrobiana debido a su poder oxidante, mediante acción directa por radicales libres 19,20 .…”

Section: Introductionunclassified

Actividad antifúngica y perfil de seguridad del producto natural derivado del aceite de maravilla ozonizado (AMO3) en dermatofitos

B³

et al. 2011

Rev. chil. infectol.

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In vitro antifungal susceptibility, in vivo antifungal activity and security from a natural product obtained from sunrise oil (AMO 3 ) against dermatophytesThis work studied safety and antifungal activity of ozonized sunfl ower oil (AMO 3 ) against dermatophytes. AMO 3 was prepared through a new original process that modifi es the oil before ozonation by alcoholic catalytic esterifi cation. Susceptibility was studied in 41 dermatophytes by agar diffusion and broth microdilution tests. The experimental model to assess the topical safety of the oil included 60 CF1 mice divided in three groups that were treated with vaseline (control), 1% AMO 3 and 50% AMO3 (overdose), respectively. Then, experimental dermatophytosis was induced in CF1 mice. Seventy-fi ve individuals were selected and divided in 5 groups that were treated once a day with placebo, cream with 1%, 2% and 3% AMO 3 plus an untreated control group. This new natural product showed antifungal activity against all strains studied. The MIC ranged between was 0,125 and 1%, while minimum fungicidal concentration (MFC) was 2%. The application of vaseline and AMO 3 1% and 50% did not produce clinical or histopathological lesions. The mice with dermatophytosis that were treated with 1%, 2% and 3% AMO 3 showed 100% clinical cure and 94% average mycological cure, exceeding placebo and control groups (p < 0,05). This product exhibits high antifungal activity and could be a safe alternative for ringworm topical treatment.Key words: Natural antifungal, ozonized oil, dermatophytosis. Palabras clave: Antifúngico natural, aceite ozonizado, dermatofi tosis.Universidad Mayor. Facultad de Medicina (PTM, VSV).Laboratorio CENTROVET (PTM).Universidad de Chile. Facultad de Ciencias Veterinarias yPecuarias (SAC). Facultad de Medicina (HRB).Los autores declaran no tener conflictos de interés. IntroducciónL as dermatofi tosis continúan siendo una causa importante de consulta, tanto en humanos como en animales 1 . Son afecciones cutáneas causadas por hongos del grupo dermatofi tos, con afi nidad para crecer sobre la queratina, la que digieren enzimáticamente y consumen como principal fuente de energía. Los dermatofi tos están integrados por los géneros Microsporum, Trichophyton y Epidermophyton, capaces de invadir y mantenerse en tejidos queratinizados, como el estrato córneo de la piel, pelos y uñas, pudiendo transmitirse entre personas, de animales al hombre y viceversa 2 . Clí-nicamente se caracterizan por producir lesiones circulares con un grado variable de eritema, descamación, prurito y alopecia cuando afecta una zona pilosa 2-4 . Según su hábitat y preferencias de hospederos, los dermatofi tos se clasifi can en tres grupos: geofílicos o habitantes del suelo, que ocasionalmente son patógenos para el hombre y los animales; zoofílicos, cuyo hospedero natural son los animales, pero frecuentemente afectan al hombre; y antropofílicos, patógenos exclusivamente humanos [1][2][3][4] . El diagnóstico de las dermatofi tosis se inicia en la anamnesis, con una completa y detallada hist...

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Atividade in vitro de extratos brutos de duas espécies vegetais do cerrado sobre leveduras do gênero Candida

Silva

Pinheiro

Queiroz

et al. 2012

Ciênc. saúde coletiva

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Avaliação da sensibilidade de cepas de Malassezia furfur a imidas cíclicas

Cited by 3 publications

References 29 publications

Pityriasis versicolor: clinical-epidemiological characterization of patients in the urban area of Buerarema-BA , Brazil

Pityriasis versicolor: clinical-epidemiological characterization of patients in the urban area of Buerarema-BA , Brazil

Actividad antifúngica y perfil de seguridad del producto natural derivado del aceite de maravilla ozonizado (AMO3) en dermatofitos

Atividade in vitro de extratos brutos de duas espécies vegetais do cerrado sobre leveduras do gênero Candida

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