Antibiofilm, Antioxidant, Antimutagenic Activities and Phenolic Compounds of Allium orientale BOISS.

Ceylan, Özgür; Aliç, Halime

doi:10.1590/s1516-89132015060309

Cited by 17 publications

(7 citation statements)

References 43 publications

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“…For example, the biofilm inhibition properties of A. sativum, A. stipitatum , A . orientale and A. porrum have been documented [ 19 , 20 , 21 , 22 ]. The inhibition of bacterial efflux pumps has also been suggested as a strategy to inhibit biofilm formation [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

et al. 2021

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The bulbs of Allium species are a known source of antibacterial phytochemicals. Anti-infective, efflux pump and biofilm inhibitory activities of bulb extracts of selected Ghanaian shallots Allium cepa var aggregatum were evaluated using the HT-SPOTi assay and other whole-cell phenotypic screening techniques to determine their possible mechanisms of action. Ethanol and aqueous extracts of white A. cepa inhibited the growth of Mycobacterium smegmatis mc2 155 and Escherichia coli, respectively. The majority of the Allium extracts significantly (p < 0.05) exhibited efflux pump inhibitory activity against all the acid-fast, Gram-positive and Gram-negative strains used. Hexane and chloroform extract of the pink A. cepa and the aqueous extract of the white A. cepa significantly inhibited M. smegmatis biofilm formation. For Pseudomonas aeruginosa, the inhibition was observed at 250 µg/mL for the aqueous extract (~77.34%) and 125 µg/mL for the hexane extract (~76.51%). The results suggest that Ghanaian shallots could potentially be useful when further developed to tackle antimicrobial resistance, particularly in tuberculosis (TB).

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Section: Discussionmentioning

confidence: 99%

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

et al. 2021

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“…Additional reports described its production in cultures of the phytopathogens Epichloë bromicola (infecting Elymus tangutorum ) [ 29 ] and Diaporthe gulyae (isolated from stem cankers of sunflower) [ 30 ]. The many biological activities reported for hydroxybenzoic acid ( 2 ) include phytotoxic activity against Rumex crispus [ 31 ] and as a growth inhibitor of Dactylis glomerate [ 32 ]; additionally, it has been reported to have antibacterial [ 15 ], antioxidant [ 33 ], antifungal [ 23 ], antialgal [ 34 ], antimutagenic [ 35 ], and estrogenic properties [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Identification and Quantification of a Phytotoxic Metabolite from Alternaria dauci

et al. 2020

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Alternaria dauci is the causal agent of Alternaria leaf blight (ALB) in carrot (Daucus carota) crops around the world. However, to date, A. dauci has received limited attention in its production of phytotoxic metabolites. In this investigation, the bioassay-guided isolation of the extract from liquid cultures of A. dauci resulted in the isolation of two metabolites identified as α-acetylorcinol (1) and p-hydroxybenzoic acid (2), based on their spectroscopic data and results from chemical correlation reactions. Testing of both metabolites in different assays showed an important phytotoxic activity for p-hydroxybenzoic acid (2) when tested in the leaf-spot assay on parsley (Petroselinum crispum), in the leaf infiltration assay on tobacco (Nicotiana alata) and marigold (Tagetes erecta), and in the immersion assay on parsley and parsnip (Pastinaca sativa) leaves. Quantification of the two metabolites in the crude extract of A. dauci kept at different times showed that p-hydroxybenzoic acid (2) is one of the first metabolites to be synthesized by the pathogen, suggesting that this salicylic acid derivative could play an important role in the pathogenicity of the fungus.

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“…In the literature, bulbs of A. subhirsutum [15] and A. roseum var. odoratissimum [32], leaves of A. ursinum [33], aerial parts of A. nigrum [15] and A. orientale [34] and flowers of A. scorodoprasum [14] have been reported to be richer in phenolics than other parts. Additionally, the phenolic compounds of some Allium species have previously been investigated quantitatively with LC.…”

Section: Discussionmentioning

confidence: 99%

Chemical profiles and biological properties of methanol extracts of Allium pallens L. from different localities in Turkey

Emir

2020

ARCH BIOL SCI BELGRA

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Many species of the Allium genus, principally the cultivated forms, are widely used as vegetables, spices and natural therapeutics due to their beneficial health properties. This study aimed to identify the phenolic composition and biological activities of the bulb, stem and flower parts of Allium pallens L., collected from two different localities. A total of 28 phenolic compounds were investigated by LC-ESI-MS/MS, and gallic acid, 4-hydroxybenzoic acid, and benzoic acid were found to be the major phenolic compounds in the plants from both locations. Total phenolic-and flavonoid-content analyses of samples were carried out using spectrophotometry, and the stem extracts were found to be rich in phenolics. DPPH, ABTS, FRAP and CUPRAC assays were used to determine the antioxidant capacities of the extracts. A linear relation was observed between the phenolic contents of the extracts and their antioxidant activities, and the stem extracts of plants from both locations were found to have potent antioxidant capacity. The inhibitory activities of the extracts against acetylcholinesterase, butyrylcholinesterase and tyrosinase were determined using a 96-well microplate reader. The antibutyrylcholinesterase activity of the extracts was found to be the highest. The outcomes of these investigations were further explored, and the underlying structure of multivariate data was revealed using principal component analysis. This study presents the distribution of chemical constituents and biological activities of the different parts of A. pallens, and also contributes to further investigations of Allium species.

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Antibiofilm, Antioxidant, Antimutagenic Activities and Phenolic Compounds of Allium orientale BOISS.

Abstract: ABSTRACT

Cited by 17 publications

References 43 publications

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

Identification and Quantification of a Phytotoxic Metabolite from Alternaria dauci

Chemical profiles and biological properties of methanol extracts of Allium pallens L. from different localities in Turkey

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