Antidepressant effects of standardized extract of Commiphora mukul Engl. in olfactory bulbectomized rats

Kalshetti, Padmaja Bhimashankar; Alluri, Ramesh; Thakurdesai, Prasad

doi:10.1590/s1516-8913201502627

Cited by 5 publications

(7 citation statements)

References 43 publications

(43 reference statements)

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“…This hyperactivity is reversed by chronic, but not acute, antidepressant treatment [ 133 ]. In addition, OBX rats demonstrated decreased time spent in open arms in the elevated plus-maze [ 137 , 138 ], prolonged immobility time in the FST [ 138 , 139 ] and reduction in sucrose intake in the sucrose preference test (SPT) [ 140 ]. OBX rats demonstrated impaired spatial learning and memory deficit in MWM, in the passive avoidance test, and in the 8-arm radial maze.…”

Section: Models Of Depressionmentioning

confidence: 99%

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Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Section: Models Of Depressionmentioning

confidence: 99%

“…Induces both anxiety- and depression-like behaviors in OF, EPM, sucrose preference, social interaction tests and memory dysfunction [ 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 ].…”

Section: Tablementioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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“…The impairment of the CREB-BDNF signal in the hippocampus and mPFC in depressive animals ( Calabrese et al, 2014 ; Daniele et al, 2015 ) has also been shown to be mediated by the overproduction of proinflammatory factors. Thus, together with a recently reported antidepressant-like effect of a standardized hydroalcoholic extract of Commiphora mukul in olfactory bulbectomized rats ( Kalshetti et al, 2015 ), we raised the possibility that Z-guggulsterone may have antidepressant-like activity. In the present study, we systematically investigated the antidepressant-like effect of Z-guggulsterone as well as its underlying mechanisms using the experiments of sucrose preference, TST, and FST in a mouse model of chronic unpredictable stress (CUS).…”

Section: Introductionmentioning

confidence: 82%

“…Commiphora mukul is also demonstrated to prevent inflammation ( Tariq et al, 1986 ; Song et al, 2010 ; Huang et al, 2016a ) and stroke ( Adams et al, 2002 ) and improve the function of the immune system ( Mencarelli et al, 2009 ). However, to date, the potential application of Commiphora mukul in depression therapy is largely unknown, though a study by Kalshetti et al (2015) has already reported an antidepresant-like activity of Commiphora mukul in olfactory bulbectomized rats. Our study provides direct evidence to show that Z-guggulsterone, an active ingredient extracted from Commiphora mukul, displays significant antidepressant-like activity in a chronic depression model, extending the role of Z-guggulsterone beyond a metabolic regulator to a potential modulator of major depression.…”

Section: Discussionmentioning

confidence: 99%

Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway

Liu

Wang

et al. 2017

International Journal of Neuropsychopharmacology

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Background:Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway. Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress mouse model of depression.Methods:The effects of Z-guggulsterone were assessed in mice with the tail suspension test and forced swimming test. Z-guggulsterone was also investigated in the chronic unpredictable stress model of depression with fluoxetine as the positive control. Changes in hippocampal neurogenesis as well as the brain-derived neurotrophic factor signaling pathway after chronic unpredictable stress/Z-guggulsterone treatment were investigated. The tryptophan hydroxylase inhibitor and the tyrosine kinase B inhibitor were also used to explore the antidepressant-like mechanisms of Z-guggulsterone.Results:Z-guggulsterone (10, 30 mg/kg) administration protected the mice against the chronic unpredictable stress-induced increases in the immobile time in the tail suspension test and forced swimming test and also reversed the reduction in sucrose intake in sucrose preference experiment. Z-guggulsterone (10, 30 mg/kg) administration prevented the reductions in brain-derived neurotrophic factor protein expression levels as well as the phosphorylation levels of cAMP response element binding protein, extracellular signal-regulated kinase 1/2, and protein kinase B in the hippocampus and cortex induced by chronic unpredictable stress. Z-guggulsterone (10, 30 mg/kg) treatment also improved hippocampal neurogenesis in chronic unpredictable stress-treated mice. Blockade of the brain-derived neurotrophic factor signal, but not the monoaminergic system, attenuated the antidepressant-like effects of Z-guggulsterone.Conclusions:Z-guggulsterone exhibits antidepressant activity via activation of the brain-derived neurotrophic factor signaling pathway and upregulation of hippocampal neurogenesis.

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“…Guggulu manages vata, and kapha, act on loss of appetite, indigestion, acne, constipation, 29 Guggulu is antidepressant 28 hence acts on GABAergic system. Anti-inflammatory 30 Due to excessive consumption of junk food, vitiation of Apana Vayu, Vyana Vayu results in Dhatu Ksaya condition.…”

Section: Discussionmentioning

confidence: 99%

Effect of Punarnavadi Guggulu in the Management of Premenstrual Syndrome – A Single Case Study

2022

IJBPAS

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Premenstrual Syndrome is an entity about which people are not much aware. No too much studies have been yet done for this particular condition. Women deals with this condition very casually. Menstruation plays an important role in women's reproductive life to get a healthy progeny. Any deviation from normalcy, indicative of any abnormality in the reproductive cycle causes a great impact on the quality of a woman's physical, emotional, social and reproductive life. Premenstrual Syndrome is the cyclical occurance of certain symptoms just prior to menses in the luteal phase of the cycle, which get resolved spontaneously on the onset of menses or just after 2 to 3 days of menses. The symptoms do not reappear within the next 13 days or before the luteal phase. A wide range of symptoms occurs in PMS. In this study "Punarnavadi Guggulu" was given for Premenstrual Syndrome, which is a combination of mainly 5 drugs namely Punarnava, Devdaru, Guduchi, Haritaki, Guggulu, and Erand Tail as bhawana dravya. Diagnosis of PMS was confirmed by the complaints described by the patients and scoring was done with the help of a screening tool (based on PMTS-OR scale). Assessment was done before treatment and after the completion of observational cycle. The patient had a pre-intervention score of 40 which was a severe

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Antidepressant effects of standardized extract of Commiphora mukul Engl. in olfactory bulbectomized rats

Abstract: ABSTRACT

Cited by 5 publications

References 43 publications

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway

Effect of Punarnavadi Guggulu in the Management of Premenstrual Syndrome – A Single Case Study

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