2015
DOI: 10.1590/s1516-8913201500022
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Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Abstract: Possible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined

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Cited by 28 publications
(22 citation statements)
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“…This increase showed heart tissue damage, which are related with myocardial infarction, cardiac failure and myocarditis (Figure 2, 3). Similar to our study in many other studies [11,16,26] there was seen an increasing level of CK-MB when treated with CYP. Our biochemical data has been expressed in the same line with other studies which observed a significant increase in AST and CK-MB levels [25,29,32].…”
Section: Tocsupporting
confidence: 92%
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“…This increase showed heart tissue damage, which are related with myocardial infarction, cardiac failure and myocarditis (Figure 2, 3). Similar to our study in many other studies [11,16,26] there was seen an increasing level of CK-MB when treated with CYP. Our biochemical data has been expressed in the same line with other studies which observed a significant increase in AST and CK-MB levels [25,29,32].…”
Section: Tocsupporting
confidence: 92%
“…These may imply that overproduction of reactive oxygen species could be reduced by the HT, in the same line, other studies indicated a decrease in the antioxidantive enzyme activity is a consequence of raised oxidative stress in the heart tissue [34,37]. This results are consistent with numerous researches [11,16,38]. In 150 mg/kg CYP treated group the level of TOC increased, which indicated CYP-related oxidative stress and cardiac toxicity.…”
Section: Tocsupporting
confidence: 88%
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