Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Çetik, Songül; Ayhancı, Adnan; Şahıntürk, Varol

doi:10.1590/s1516-8913201500022

Cited by 28 publications

(24 citation statements)

References 25 publications

(24 reference statements)

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“…This increase showed heart tissue damage, which are related with myocardial infarction, cardiac failure and myocarditis (Figure 2, 3). Similar to our study in many other studies [11,16,26] there was seen an increasing level of CK-MB when treated with CYP. Our biochemical data has been expressed in the same line with other studies which observed a significant increase in AST and CK-MB levels [25,29,32].…”

Section: Tocsupporting

confidence: 92%

“…These may imply that overproduction of reactive oxygen species could be reduced by the HT, in the same line, other studies indicated a decrease in the antioxidantive enzyme activity is a consequence of raised oxidative stress in the heart tissue [34,37]. This results are consistent with numerous researches [11,16,38]. In 150 mg/kg CYP treated group the level of TOC increased, which indicated CYP-related oxidative stress and cardiac toxicity.…”

Section: Tocsupporting

confidence: 88%

“…We may conclude that high-dose chemotherapy regimens together with using CYP may frequently associated with cardiotoxicity that could lead to myocyte devastation and congestive heart failure and CYP toxicity might be the result of increased permeability of cardiac mitochondrial membrane. As a matter of fact, this result has also been expressed by similar studies [16,26]. Overproduction of reactive oxygen species leads to the oxidative stress, DNA injury, cellular membrane impairment and necrosis in cells and tissues [27].…”

Section: Discussionmentioning

confidence: 63%

“…Therefore, there is a need for strong and more effective agents that can protect the healthy cells and tissues from chemotheraputic toxicities but without tumour protection. In the numerous researches [2,16,25] it is reported that medicinal plant-based natural compounds might supply protective effects against CYP induced toxicity. Moreover it was demonstrated that medicinal plants contain large amounts of antioxidant properties and prevent adverse effect of free radicals-induced oxidative stress [20].…”

Section: Discussionmentioning

confidence: 99%

“…CYP-related cardiotoxicity was related with depression of the antioxidant defense mechanism [13,14]. Antioxidant' s protective roles become very crucial to avoid from toxicity of drugs [15,16]. Antioxidant agents can detoxify the toxic effects of undesirable agents.…”

mentioning

confidence: 99%

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Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats

Yıldız¹,

Keskin²,

Şahıntürk³

et al. 2018

jrp

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Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifolium Turra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino rats were randomly divided into 9 groups, each included 7 animals. Serum creatine kinase-MB (CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.

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Section: Tocsupporting

confidence: 92%

Section: Tocsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats

Yıldız¹,

Keskin²,

Şahıntürk³

et al. 2018

jrp

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Cardioprotective effects of curcumin and carvacrol in doxorubicin‐treated rats: Stereological study

Jafarinezhad

Rafati

Ketabchi

et al. 2019

Food Science & Nutrition

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Doxorubicin (DOX) is a cardiotoxic drug. To reduce the harmful effects of DOX, two plant‐derived components, including curcumin (CUR) and carvacrol (CAR), were considered. This study aimed to assess the protective effects of CUR and CAR on DOX‐induced cardiotoxicity using physiological and stereological evaluations. Male rats were randomly allocated to six groups. Group's I‐VI received phosphate‐buffered saline (PBS), CUR (100 mg kg−1 day−1), CAR (50 mg kg−1 day−1), DOX (4 mg kg−1 week−1), DOX‐CUR, and DOX‐CAR, respectively. On day 24, plasma troponin I and ECG were analyzed and the left ventricle underwent stereological assessment. The results showed a fivefold increase in troponin I in the DOX‐treated animals compared to the PBS ones. Additionally, heart rate and QRS amplitude, respectively, reduced by 18% and 31% and QT interval and QRS duration, respectively, increased by 41% and 24% in the DOX group in comparison with the PBS rats (p < .05). The total volume of the myocardium and vessels and the number of cardiomyocyte nuclei also, respectively, decreased by 30%, 45%, and 43% in the DOX group compared to the PBS animals (atrophy of the ventricular tissues, p < .01). Besides, the mean volumes of the connective tissue and cardiomyocytes, respectively, increased by 46% and 52% in the DOX group (p < .01). In the DOX‐CUR and DOX‐CAR groups, the changes were prevented extensively in comparison with the DOX group (p < .01). Co‐administration of CUR or CAR and doxorubicin for 24 days could improve the heart function and structural changes.

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Therapeutic application of carvacrol: A comprehensive review

Imran¹,

Aslam

Alsagaby

et al. 2022

Food Science & Nutrition

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Carvacrol is a major natural constituent and is significantly present as an essential oil in aromatic plants and is well known for its numerous biological activities. Therapeutic properties of carvacrol have been demonstrated as anti‐oxidant, anticancer, diabetes prevention, cardioprotective, anti‐obesity, hepatoprotective and reproductive role, antiaging, antimicrobial, and immunomodulatory properties. The carvacrol biosynthesis has been mediated through mevalonate pathway. Carvacrol has the anticancer ability against malignant cells via decreasing the expressions of matrix metalloprotease 2 and 9, inducing apoptosis, enhancing the expression of pro‐apoptotic proteins, disrupting mitochondrial membrane, suppressing extracellular signal‐regulated kinase 1/2 mitogen‐activated protein kinase signal transduction, and also decreasing the phosphoinositide 3‐kinase/protein kinase B. It also decreased the concentrations of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase, and gamma‐glutamyl transpeptidase as well as also restored liver function, insulin level, and plasma glucose level. Carvacrol also has been found to exert antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Coagulase‐negative staphylococcus, Salmonella spp., Enterococcus sp. Shigella, and Escherichia coli. The current review article summarizes the health‐promoting perspectives of carvacrol through various pathways.

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Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

Abstract: Possible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined

Cited by 28 publications

References 25 publications

Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats

Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats

Cardioprotective effects of curcumin and carvacrol in doxorubicin‐treated rats: Stereological study

Therapeutic application of carvacrol: A comprehensive review

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