Hepatic Cytochrome P450 as Biomarkers of Cypermethrin Toxicity in Freshwater Teleost, Channa punctatus (Bloch)

Bhutia, Dawa; Kishore, Benoy; Pal, Joydeb

doi:10.1590/s1516-8913201400049

Cited by 13 publications

(1 citation statement)

References 22 publications

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“…Many drugs may increase or decrease the activity of various CYP isozymes either by inducing the biosynthesis of an isozyme (enzyme induction) or by directly inhibiting the activity of the CYP (enzyme inhibition). Many studies deal with Cytochromes P450 as biomarkers of xenobiotic exposure in the liver but also in the blood (easy ante-mortem analysis) thanks to plasma exosomes [e.g., (205)(206)(207)(208)(209)(210)(211)(212)(213)(214)]. This enzyme family is really wellstudied and known, and methodologies already exist for this kind of application, thus it is a promising approach.…”

Section: Toward New Tools To Develop Biomarkers For Sublethal Effectsmentioning

confidence: 99%

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

et al. 2020

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The widespread use of pesticides to control agricultural pests is a hot topic on the public scene of environmental health. Selective pest control for minimum environmental impact is a major goal of the environmental toxicology field, notably to avoid unintended poisoning in different organisms. Anticoagulant rodenticides cause abnormal blood coagulation process; they have been widely used to control rodents, allowing inadvertent primary and secondary exposure in domestic animals and non-target predatory wildlife species through direct ingestion of rodenticide-containing bait or by consumption of poisoned prey. To report toxic effect, the most common approach is the measurement of liver or plasma residues of anticoagulant rodenticides in dead or intoxicated animals showing clinical symptoms. However, one major challenge is that literature currently lacks a hepatic or plasma concentration threshold value for the differentiation of exposure from toxicity. Regarding the variation in pharmacology properties of anticoagulant rodenticides inter- and intra-species, the dose-response relationship must be defined for each species to prejudge the relative risk of poisoning. Beyond that, biomarkers are a key solution widely used for ecological risk assessment of contaminants. Since anticoagulant rodenticides (AR) have toxic effects at the biochemical level, biomarkers can serve as indicators of toxic exposure. In this sense, toxicological knowledge of anticoagulant rodenticides within organisms is an important tool for defining sensitive, specific, and suitable biomarkers. In this review, we provide an overview of the toxicodynamic and toxicokinetic parameters of anticoagulant rodenticides in different animal species. We examine different types of biomarkers used to characterize and differentiate the exposure and toxic effects of anticoagulant rodenticide, showing the strengths and weaknesses of the assays. Finally, we describe possible new biomarkers and highlight their capabilities.

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Section: Toward New Tools To Develop Biomarkers For Sublethal Effectsmentioning

confidence: 99%

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

et al. 2020

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Toxic effects of pyrethroids in tadpoles of Physalaemus gracilis (Anura: Leptodactylidae)

et al. 2019

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Commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate and their effects on antioxidant defence system and oxidative stress indices in Cyprinus carpio L.: an integrated in silico and in vivo approach

Bhattacharya

Chatterjee

et al. 2022

Environ Sci Pollut Res

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Hepatic Cytochrome P450 as Biomarkers of Cypermethrin Toxicity in Freshwater Teleost, Channa punctatus (Bloch)

Abstract: In this study, Channa punctatus was treated with sub-lethal concentration of cypermethrin (6.6

Cited by 13 publications

References 22 publications

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

Toxic effects of pyrethroids in tadpoles of Physalaemus gracilis (Anura: Leptodactylidae)

Commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate and their effects on antioxidant defence system and oxidative stress indices in Cyprinus carpio L.: an integrated in silico and in vivo approach

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