Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Braz. arch. biol. technol.

2016

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Section: Discussionsupporting

confidence: 90%

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Braz. arch. biol. technol.

2016

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“…This situation is supported by a previous study (45). In addition, Apaydin et al (4) indicated in their study that lead nitrate treated diabetic rats were more sensitive than diabetic rats without lead nitrate treatment.…”

Section: Figure 6 (A) Liver Section Of Control Rats Cv: Central Veinsupporting

confidence: 61%

“…It causes morbidity and mortality due to the development of vascular complications like nephropathy and cardiovascular diseases. Owing to its quick global spread, diabetes mellitus is regarded as a considerable health problem (4).…”

mentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Pandır

Archives of Industrial Hygiene and Toxicology

2016

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Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

“…Heavy metals are commonly used generally in world and affect the function and damage the structure of many organs by causing oxidative damages (Garcia-Nino & Pedraza-Chaverri, 2014;Apaydin et al, 2015;Baş et al, 2015b). Lead and cadmium treatments are consistent with oxidative damage in various tissues (Merra et al, 2014;Djuric et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol

Apaydın

Commagene Journal of Biology

2021

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Lead and cadmium are known as environmental pollutants extensively found in food and water that induce hazards to animals' and people's health. Sesamol is a dietary antioxidant that is found in some plants. Epididymis is known to play an important role in the maturation and storage of the sperm. The spleen is an important organ involved in the immune response.The present study aims to analyze the oxidative stress in spleen and epididymis. Therefore, Lead (LN) (90 mg/kg bw per day, 1/25 LD50), Cadmium (CdCl2) (3 mg/kg bw per day, 1/25 LD50), and sesamol (50 mg/kg bw per day) were given to rats by gavage for 28 days. Antioxidant enzyme activities in epididymis and spleen tissues [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S transferase], malondialdehyde (MDA) were investigated at the end of 28 days comparatively with the control group. It is revealed that there is a significant decline in the antioxidant enzymes and increase in MDA levels in the spleen and epididymis tissues of the lead and cadmium treated rats compared to the control group. A small increase in these parameters was also observed in the sesamol treated groups.