Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Sankako, Michele Kimie; Garcia, Patrícia Carvalho; Piffer, Renata C.; Pereira, Olga

doi:10.1590/s1516-89132013000100012

Cited by 9 publications

(5 citation statements)

References 47 publications

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“…In the present study, the intraperitoneal injection of nicotine resulted degenerative changes in the seminiferous tubules and reduction in sperm count and motility, decrease of testosterone hormone and testis weight, and impairment of sperm cells evidence for this toxicity. This is in agreement with results of Sankako et al who reported residual damage on sperm concentration, motility, and morphology after cigarette smoke exposure ( 19 ).…”

Section: Discussionsupporting

confidence: 93%

Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

et al. 2014

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SUMMARY:Nicotine consumption can decrease fertility drive in males through inducing oxidative stress and DNA damage. The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. In this study, various doses of curcumin (10, 30 and 60 mg/kg) and curcumin plus nicotine (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters were determined. The results indicated that nicotine administration (0.5 mg/kg) significantly decreased testosterone level, count and motility of sperms, and testis weight compared to control group. However, increasing the dose of curcumin significantly increased reproductive indices in most of the groups. Thus, it seems that curcumin inhibits nicotine-induced adverse effects on reproductive parameters.

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Section: Discussionsupporting

confidence: 93%

Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

et al. 2014

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“…Cigarette smoking and nicotine administration are recognized to reduce the male sexual function in animals and humans: a number of epidemiological and experimental studies show effects similar to those observed in NT-treated rats by our study (Patterson et al, 1990;Polyzos et al, 2009;Jana et al, 2010;Gaur et al, 2007;Oyeyipo et al, 2011;Wong et al, 2000;Sankako et al, 2013). We observed decreased testosterone levels as well as reduced presence of Leydig and Sertoli cells in the testes of NT-treated rats, which are findings suggestive of an impaired androgen production.…”

Section: Discussionsupporting

confidence: 79%

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Mosbah

Yousef

Mantovani

2015

Experimental and Toxicologic Pathology

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“…The nicotine acts as an endocrine disorganizer of male hormones [25,26], which promotes negative effects in the reproduction. The substance reduces the number of spermatozoa [27], increases the number of abnormal gametes and promotes changes in the testicular tissue [28][29][30].…”

Section: Histopathological and Morphometric Evaluation In The Testis mentioning

confidence: 99%

Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine

Souza¹,

Mathias²,

Souza³

et al. 2017

J Interdiscipl Histopathol

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Objective: Frequently, reproductive toxic substances such as androgenic anabolic steroids, alcohol and nicotine are used in association by adolescents and adults, in an indiscriminate manner. This study investigated the testicular and epididymal tissue of adult rats submitted to a recovery period after treatment with anabolic steroid, alcohol and /or nicotine. Materials and Methods: The animals (n=42) were divided into three control groups simulating the drugs administration routes (CI: distilled water, oral; CII: saline solution, subcutaneous; CIII: water and saline solution) and groups treated with a testosterone esters mixture (T: 7.5 mg/kg body weight-b.w., subcutaneous), alcohol (AL: 3.5 g/kg b.w. of ethanol 25%, oral), nicotine (N: 2.0 mg/kg b.w., subcutaneous), and co-administration of these three substances (T/AL/N). After 15 consecutive days of treatment (once a day), the animals were kept for 30 days in recovery. At the end of this period, the testes and epididymides were collected, weighed and processed for histological and morphometric analysis by light microscope. Results: All groups treated with toxic substances presented histopathological changes in testes and epididymis after the recovery period. There was a significant decrease (p<0.05) in testicular weight and in the morphometric parameters of the testis and epididymis in T and T/AL/N groups. Conclusion: The testis and epididymis of rats treated with anabolic steroid, alcohol and/or nicotine exhibited histopathological changes after a recovery period and the damages were more evident in the groups receiving the anabolic steroid alone or co-administered with other drugs.

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Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Abstract: ABSTRACT

Cited by 9 publications

References 47 publications

Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea extract

Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine

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