Neonatally induced diabetes: liver glycogen storage in pregnant rats

Iessi, Isabela Lovizutto; Bueno, Aline; Sinzato, Yuri Karen; Spada, Ana Paula Machado; Rudge, Marilza Vieira Cunha; Heubel, Maricê Thereza Correa Domingues; Damasceno, Débora Cristina

doi:10.1590/s1516-89132012000200010

Cited by 1 publication

(2 citation statements)

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“…In general terms, depending on the animal strain, dose, route of administration and the day of streptozotocin injection after birth, STZ models exhibit different degrees of diabetes intensity or, eventually, only glucose intolerance 23,24 . Concerning diabetic intensity, the n5‐STZ model may mimic different diabetic situations, which can be classified as severe (PPG above 200 mg/dL) 25,26 or mild (PPG between 120 and 300 mg/dL) 9,10 . Additionally, PPG values between 200 and 300 mg/dL have been classified either as severe or mild by different researchers 26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Several experimental models have been used to mimic the complications and evolution of human T2D 7,8 . In this study, we chose the n5‐STZ model, obtained by a single injection of streptozotocin (STZ) in 5‐day‐old rats, which triggers mild diabetes 9,10 and mimics time‐dependent pathological alterations of T2D 11,12 . STZ model disclosed lung impairment, evidenced by increased redox imbalance, 13,14 alveolar collapse, septal thickening, cellular infiltration and parenchymal haemorrhage 15 .…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary impairment in type 2 diabetic rats and its improvement by exercise

et al. 2021

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Aim We aimed to evaluate whether the streptozotocin‐induced diabetic model can generate lung functional, histological and biochemical impairments and whether moderate exercise can prevent these changes. Methods Wistar rats were assigned to control (CTRL), exercise (EXE), diabetic (D) and diabetic with exercise (D+EXE) groups. We used the n5‐STZ model of diabetes mellitus triggered by a single injection of streptozotocin (STZ, 120 mg/kg b.w., i.p.) in newborn rats on their 5th day of life. EXE and D+EXE rats were trained by running on a motorized treadmill, 5 days a week for 9 weeks. Blood glucose, body weight, food intake, exercise capacity, lung mechanics, morphology, and antioxidant enzymatic activity were analysed. Results On the 14th week of life, diabetic rats exhibited a significant impairment in post‐prandial glycaemia, glucose tolerance, body weight, food intake, lung function (tissue viscance, elastance, Newtonian resistance and hysteresis), morphological parameters, redox balance and exercise capacity. Physical training completely prevented the diabetes‐induced alterations, except for those on fasting blood glucose, which nevertheless remained stable. Conclusions Mild diabetes in n5‐STZ‐treated rats jeopardized pulmonary mechanics, morphology and redox balance, which confirms the occurrence of diabetes‐induced pneumopathy. Moreover, moderate exercise completely prevented all diabetes‐induced respiratory alterations.

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