Higher than normal plasma Iinterleukin-6 concentrations in brazilian patients with mood disorders

Miranda, Helen Cristina; Nunes, Sandra Odebrecht Vargas; Reiche, Edna Maria Vissoci; Oda, Julie Massayo Maeda; Watanabe, Maria Angélica Ehara

doi:10.1590/s1516-89132011000400010

Cited by 4 publications

(4 citation statements)

References 27 publications

(23 reference statements)

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“…In contrast, stress may exacerbate immunopathology, if the enhanced immune response is dysregulated following prolonged activation, as seen during chronic stress [ 9 ]. Chronic stress has also been shown to alter the expression of cytokines, such as interleukin (IL)-1 and IL-6 [ 10 ]. In studies of the splenocytes of subordinate animals, high levels of the proinflammatory cytokines including IL-6 and tumor necrosis factor (TNF)-α were secreted [ 11 - 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dominant/Subordinate Social Status on Formalin-Induced Pain and Changes in Serum Proinflammatory Cytokine Concentrations in Mice

et al. 2013

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Current investigations regarding social stress primarily focus on the health consequences of being in stressful social hierarchies. The repetitive nature of social conflicts seems to favor an induction of hyperalgesia or hypoalgesia, both in rodents and humans. Additionally, social conflicts may affect the immune system. In order to better establish the pain and immune responses to stress, the present study implemented a sensory contact model on 32 male BALB/c mice. Subsequent to establishing a dominance/submissive social relationship, each mouse was injected with formalin (20 μl, 2%) and their pain behavior was scored and serum concentrations of proinflammatory cytokines IL-1 and IL-6, and corticosterone were also measured. Test results revealed that subordinate mice were hypoalgesic during chronic phase of formalin test compared to control and dominant mice (P<0.05). On the other hand, subordinate mice were hyperalgesic compared to dominant mice during the whole acute phase of formalin test (P<0.05). Corticosterone, IL-1 and IL-6 concentrations were much higher in serum of dominant and subordinate mice than in the control group (p<0.05). The results indicated that, although both dominant and subordinate animals displayed an increase in serum corticosterone and proinflammatory cytokines during social interactions, their response to pain perception differently was affected with the social status.

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Section: Introductionmentioning

confidence: 99%

Effects of Dominant/Subordinate Social Status on Formalin-Induced Pain and Changes in Serum Proinflammatory Cytokine Concentrations in Mice

et al. 2013

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“…Significantly higher TNF-α concentrations are associated with lower hippocampal volumes suggesting association between inflammation and neuronal damage. [27][28][29] A study conducted by Nishuty showed that patients who are depressed will have an increase in the inflammatory biomarker IL-6 compared to CRP and also in cases of depressed patients who are resistant to antidepressant drugs showing the same thing. Nishuty's research in cases of depression showed an increase in IL-6 concentration of 2.94 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of biomarker proinflammation of depression in traumatic brain injury

Ate

Wariki²,

Warouw³

et al. 2022

Int J Res Med Sci

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Depression is one of the long-term complications of traumatic brain injury (TBI) associated with the inflammatory process. This study aims to analyze the role of proinflammatory biomarkers on depression due to TBI and determine the types of proinflammatory biomarkers of depression in TBI. This systematic review and meta-analysis used the preferred reporting items for systematic reviews and meta-analyses (PRISMA) protocol with the population, intervention, comparison, outcome method. The selected research articles consisted of 4 cohort studies and 2 cross-sectional studies. Participants were all participants who experienced TBI without any previous infectious disease and neurobehavior disorders. Article searches are limited to the last 10 years using digital libraries including Pubmed, Science Direct, Wiley, Google Scholar. Assessment of the risk of bias using the ROBINS-1 tool, research quality using the GradePro application, and meta-analysis using review manager software 5.4.1. The results of a meta-analysis of proinflammatory biomarkers of depression using 2 cross-sectional studies showed a risk of bias and a moderate level of certainty. The most common types of proinflammatory biomarkers are IL-6, TNF-α, and IL-10. These proinflammatory biomarkers are markers of depression in TBI and have an effect on depression in TBI, especially in recurrent TBI and high post-traumatic stress disorder with depression accompanied by an increase in the concentration value of these biomarkers. Increased proinflammatory biomarkers IL-6, TNF-α, and IL-10 were found in depression with TBI. This proinflammatory biomarker has a significant relationship so that it can be used as a marker of depression in TBI.

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“…Psychological test results also showed that in the treatment group, patients got better condition than the control group after getting art therapy the level of anxiety The results of this research indicated that the physical-mental conditions are essentially related to each other and may affect the amount of cytokine IL-6 in the blood. The condition of a person with a mental disorder such as major depressive disorder may increase the amount of cytokine IL-6 because it can affect to proinflammatory cytokines [15]- [17].…”

Section: Treatment Anxiety Depression Anxiety Depressionmentioning

confidence: 99%

The Benefit of Renewable Indonesian Traditional Therapyto Enhance Recovery of Physical-Mental Illness

Sudjiwanati¹,

Suparno²

2018

Proceedings of the 5th International Conference on Community Development (AMCA 2018)

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Renewable Indonesian traditional therapies: holomerispot manipulation is a natural, nochemical treatment that can be used to improve mental health and reduce symptoms of physical illness. This study aims to prove the influence of holomerispot manipulation therapy on a key immune mediator: cytokine interleukin-6 (IL-6). The research method used was experimental research with pre and post-therapy repetition with control group. The sample was 20 people divided into 2 groups, which each group got different treatment. Group 1 was the control group and group 2 was the treatment group with holomerispot manipulation and art therapy. The results suggested that the treatment group showed lower IL-6 values compared to the control group. Based on the results of the psychological tests, the treatment group showed a decrease in the level of anxiety and depression, which was better than the control group. The conclusion of this study is that holomerispot manipulation therapy and Art therapy can improve healing and reduce symptoms of mentalphysical illness of the patients. The holomerispot therapy manipulation and art therapy are able to reduce physical-mental illness through the degradation levels of IL-6.

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Higher than normal plasma Iinterleukin-6 concentrations in brazilian patients with mood disorders

Cited by 4 publications

References 27 publications

Effects of Dominant/Subordinate Social Status on Formalin-Induced Pain and Changes in Serum Proinflammatory Cytokine Concentrations in Mice

Effects of Dominant/Subordinate Social Status on Formalin-Induced Pain and Changes in Serum Proinflammatory Cytokine Concentrations in Mice

Systematic review and meta-analysis of biomarker proinflammation of depression in traumatic brain injury

The Benefit of Renewable Indonesian Traditional Therapyto Enhance Recovery of Physical-Mental Illness

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