Acute intraperitoneal mercury chloride contamination and distribution in liver, muscle and gill of a neotropical fish Hoplias malabaricus (BLOCK, 1794)

Jesus, Taise Bomfim de; Almeida, Priscila Gontijo Aguiar de; Vergílio, Cristiane dos Santos; Machado, André Luiz dos Santos; Carvalho, Carlos Eduardo Veiga de

doi:10.1590/s1516-89132011000200021

Cited by 11 publications

(6 citation statements)

References 38 publications

(31 reference statements)

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“…They also argued that metals in the liver increase quickly during the treatment. The highest level of mercury reported in the liver in the present investigation is similar to the results reported by many researchers (11,19,21,22,24). Abreu et al (25), meanwhile, reported that about twice as much mercury accumulated in the liver as in the muscles.…”

Section: Discussionsupporting

confidence: 92%

“…High levels of mercury in the gills of the Hg-treated fish were also reported by Vergilio et al (11), Liao et al (19), Oliveira et al (20), and Chavan and Muley (21), and they support the present study. de Jesus et al (22) also reported significantly high levels of mercury in the gills of treated fish. They argued that the mercury is transported to the gills through blood for the excretion and this also supports our study.…”

Section: Discussionmentioning

confidence: 94%

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Accumulation and histological transformation in the gills, liver, muscles, and skin in Oreochromis niloticus induced by mercury

Al‐Ghanim¹,

Ahmad²,

Al-Balawi³

et al. 2019

Turk J Vet Anim Sci

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Specimens of Oreochromis niloticus (One control and 3 experimental groups) were fed diets mixed with different doses of mercury (control group = free of mercury; group 1 = 500 mg/kg; group 2 = 750 mg/kg, and group 3 = 1000 mg/kg) for 60 days in order to study its accumulation and histopathological alterations in the liver, gills, skeletal muscles, and skin. The results obtained revealed that mercury accumulation was significantly (P < 0.05) high in the liver and gills compared to the muscles and skin. The order of accumulation in these organs revealed to be liver > gills > muscles > skin. The fish fed various doses of mercury also showed histological alterations in these organs. Epithelial lifting and epithelial hypertrophy were seen in the gills of the treated fish. Fusion of secondary lamellae was also apparent. The effects were more pronounced in fish fed high doses (1000 mg/kg). Necrosis of hepatocytes and portal veins was also observed in the livers of the treated fish. Irregular muscle bundles and irregularly bigger gaps between the muscle bundles were evident in the skeletal muscles of fish fed diets with mercury, along with some structural changes in the skin of the fish fed mercury-mixed diets. The results obtained clearly indicate that mercury causes deleterious effects on the different organs of fish at even low dose (500 mg/kg).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Accumulation and histological transformation in the gills, liver, muscles, and skin in Oreochromis niloticus induced by mercury

Al‐Ghanim¹,

Ahmad²,

Al-Balawi³

et al. 2019

Turk J Vet Anim Sci

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“…Several authors have tested different mercury concentrations administered through diet, ambient water or intraperitoneal injection, using both acute and chronic tests; different parameters have been used to assess the effect of this pollutant on fish liver ( i.e. , gene expression, proteomic, transcriptome analysis, DNA microarray, biochemical) [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ], but very few studies have focused on histological and ultrastructural alterations [ 9 , 22 , 30 , 31 ]. Studies on mercury have mainly focused on methyl mercury (MeHg) [ 9 , 13 , 14 , 15 , 23 , 30 ], and the iHg effects have been substantially underestimated despite the evidence that this form mainly accumulates in the kidney and in the liver of fishes [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio)

Macirella

Guardia

Pellegrino

et al. 2016

IJMS

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Mercury (Hg) is a highly hazardous pollutant widely used in industrial, pharmaceutical and agricultural fields. Mercury is found in the environment in several forms, elemental, inorganic (iHg) and organic, all of which are toxic. Considering that the liver is the organ primarily involved in the regulation of metabolic pathways, homeostasis and detoxification we investigated the morphological and ultrastructural effects in Danio rerio liver after 96 h exposure to two low HgCl 2 concentrations (7.7 and 38.5 µg/L). We showed that a short-term exposure to very low concentrations of iHg severely affects liver morphology and ultrastructure. The main effects recorded in this work were: cytoplasm vacuolization, decrease in both lipid droplets and glycogen granules, increase in number of mitochondria, increase of rough endoplasmic reticulum and pyknotic nuclei. Pathological alterations observed were dose dependent. Trough immunohistochemistry, in situ hybridization and real-time PCR analysis, the induction of metallothionein (MT) under stressor conditions was also evaluated. Some of observed alterations could be considered as a general response of tissue to heavy metals, whereas others (such as increased number of mitochondria and increase of RER) may be considered as an adaptive response to mercury.

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“…Some studies observed AChE inhibition due to mercury exposure [10], [12], [13], [18], [19], [20], [21], [22]. Jesus et al [23], [24], when considering neotropical fish species, evaluated possible effects on acetylcholinesterase activity and internal distribution of mercury in a carnivorous species (Hoplias malabaricus), using intraperitonial injections of mercury and methylmercury chlorides. Costa et al [25] observed an inhibition of this enzyme on Hoplias malabaricus, using a methylmercury exposure dose of 75 ng g -1 , in laboratory conditions, after 70 days of exposure to this contaminant by contaminated food ingestion (the preys were artificially contaminated with intraperitoneal injections).…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase Activity in Fish Exposed to Mercury in Guanabara Bay, RJ, Brazil

Rodrigues¹,

Carvalheira²,

Gomes³

et al. 2018

EPP

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Acetylcholinesterase (AChE) is an important regulatory enzyme that controls the transmission of nerve impulses across cholinergic synapses. This study evaluated AChE activity as an effect biomarker for ecological risk assessment related to mercury contamination in fish from Guanabara bay, Rio de Janeiro State, Brazil. A total of 30 fishes were collected, 14 specimens of Genidens genidens and 16 specimens of Haemulon sp. at three sampling stations. AChE activity varied from 0.18 to 1.29 µmol min-1 mg-1 protein for G. genidens and a negative correlation between AChE activity in muscles and mercury concentrations in kidney was found (-0.55; p<0.05; n=14). For Haemulon sp. the enzyme activity showed a smaller range (0.06 to 0.22 µmol min-1 mg-1 protein) and a negative correlation between mercury concentrations in muscles and AChE activity was found (r =-0.570; p<0.05; n=16), suggesting a decrease on enzymatic response in specimens with higher mercury bioaccumulation.

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Acute intraperitoneal mercury chloride contamination and distribution in liver, muscle and gill of a neotropical fish Hoplias malabaricus (BLOCK, 1794)

Abstract: ABSTRACT

Cited by 11 publications

References 38 publications

Accumulation and histological transformation in the gills, liver, muscles, and skin in <i>Oreochromis</i> <i>niloticus</i> induced by mercury

Accumulation and histological transformation in the gills, liver, muscles, and skin in <i>Oreochromis</i> <i>niloticus</i> induced by mercury

Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio)

Acetylcholinesterase Activity in Fish Exposed to Mercury in Guanabara Bay, RJ, Brazil

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