GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil

Abstract

ABSTRACT

The Antibacterial Activity of Nigella Sativa Against Multi-Drug Resistant Pseudomonas Aeruginosa Isolated From Diabetic Wound Infections

“…The antimicrobial activity of N. sativa oil was recommended against several MDR bacteria isolated from wound infections and may be used topically in susceptible cases (Salman,Khan & Shukla, 2008;Gerige,Gerige& Rao, 2009;Falsafiet al, 2015). EOs may disrupt the structure of different fatty acids, polysaccharides,and phospholipids layers present in the cell wall and cytoplasmic membrane (Longbottom, Carson, Hammer, Mee& Riley, 2004).…”

Exploring anti-yeast activity of Nigella sativa seed extracts

“…These results obtained due to impact of different phytochemicals that are responsible for the cell membrane disruption followed by leakage of cytoplasmic constituents and other reasons may include granulation cytoplasm, and inactivation or inhibition of intercellular and extracellular enzymes synthesis (Stangarlin et al, 1999). Some other reports demonstrated antiyeast activity of N. sativa seed extract in comparison with other pathogenic microorganisms; Gerige et al (2009) reported the antiyeast activity from essential oils of N. sativa against C. albicans MTCC 184 whereas Khan and Sultana (2005) and Bita et al (2012) reported that the methanolic and aqueous extracts of N. sativa seed extracts and its oil shows strongest inhibitory activity against C. albicans. However, the mechanism of anti-yeast activities is yet to be explored.…”

Interaksi Ekstrak Etanol Biji Nigella sativa Terhadap Bakteri Probiotik dan Patogen

“…Hal ini disebabkan karena selama ini di masyarakat cenderung belum ada aturan pakai yang didasarkan atas pertimbangan keseimbangan flora normal di tubuh. Gerige et al (2009), menyebutkan bahwa terkait sensitivitas bakteri terhadap senyawa aktif dalam biji N. sativa, bakteri Gram negatif adalah golongan bakteri yang lebih sensitif dibandingkan dengan bakteri Gram positif. Adanya senyawa á-thujene, 2(1H)-naphthalenone, a-pinene, aphellandrene, limonene, thymoquinone, myristicin dalam biji N. sativa adalah senyawa-senyawa yang berkontribusi memunculkan aktivitas antimikroba.…”